Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John's wort)

Skin Pharmacology and Applied Skin Physiology

Volumn 12, Issue 5, 1999, Pages 299-304

  Schempp, Christoph M ^b   Winghofer, Barbara ^c   Langheinrich, Martin ^a   Schöpf, Erwin ^c   Simon, Jan C ^c  

^a Lichtwer Pharma AG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c NONE

Author keywords

Fluorescence detection; High performance liquid chromatography; Hypericin; Interstitial fluid

Indexed keywords

HYPERICIN; HYPERICUM PERFORATUM EXTRACT; PSEUDOHYPERICIN;

ARTICLE; BLISTER; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; ORAL DRUG ADMINISTRATION; PHOTOTOXICITY; PRIORITY JOURNAL; SERUM;

ADULT; ANTIDEPRESSIVE AGENTS; BLISTER; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; PERYLENE; PLANT EXTRACTS; SKIN; SPECTROMETRY, FLUORESCENCE; THEALES;

EID: 0032771917     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000066256     Document Type: Article

References (16)

1. Duran N, Song PS: Hypericin and its photodynamic action. Photochem Photobiol 1986;43:677-680.
2. Meruelo D, Lavie G, Lavie D: Therapeutic agents with dramatic antire-troviral activity and little toxicity at effective doses: Aromatic polycyclic diones hypericin and pseudohypericin. Proc Natl Acad Sci USA 1988; 85:5230-5234.
3. Lavie G, Valentine F, Levin B, Mazur J, Gallo G, Lavie D, Weiner D, Meruelo D: Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. Proc Natl Acad Sci USA 1989; 86:5963-5967.
4. Linde K, Ramirez G, Muirow CD, Pauls A, Weidenhammer W, Melchart D: St John's wort for depression - An overview and metaanalysis of randomized clinical trials. Br Med J 1996;313:253-258.
5. Hadjur C, Richard MJ, Parat MO, Jardon P, Favier A: Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells. Photochem Photobiol 1996;64:375-381.
6. Kil KS, Yum YN, Seo SH, Lee KT: Antitumor activities of hypericin as a protein tyrosine kinase blocker. Arch Pharmacol Res 1996;19:490-496.
7. Vandenbogaerde AL, Cuveele JF, Proot P, Himpens BE, Merlevede WJ, de Witte PA: Differential cytotoxic effects induced after photosensitization by hypericin. J Photochem Photobiol B 1997;8:136-142.
8. Chung PS, Saxton RE, Paiva MB, Rhee CK, Soudant J, Mathey A, Foote C, Castro DJ: Hypericin up-take in rabbits and nude mice transplanted with human squamous cell carcinomas: Study of a new sensitizer for laser phototherapy. Laryngoscope 1994;104:1471-1476.
9. Koren H, Schenk GM, Jindra RH, Alth G, Ebermann R, Kubin A, Konderhold G, Kreitner M: Hypericin in phototherapy. J Photochem Photobiol B 1996;36:113-119.
10. Schempp CM, Simon-Haarhaus B, Heine A, Schöpf E, Simon JC: In vitro and in vivo activation of hypericin with the incoherent light source PDT 1200 SOA (520-750 nm) and with solar simulated radiation (290-2,500 nm). Photodermatol Photoimmunol Photomed 1999; 15:13-17.
11. Giese AC: Hypericism. Photochem Photobiol Rev 1980;5:229-255.
12. Staffeldt B, Kerb R, Brockmöller J, Ploch M, Roots I: Pharmacokinetics of hypericin and pseudohypericin after oral intake of the Hypericum perforatum extract LI 160 in healthy volunteers. J Geriatr Psychiatr Neurol 1994;7(suppl 1):S47-S53.
13. Kerb R, Brockmöller J, Staffeldt B, Ploch M, Roots I: Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin. Antimicrob Agents Chemother 1996; 40:2087-2093.
14. Micali G, Lanuzza F, Currò P: High-performance liquid chromatographic determination of the biologically active principle hypericin in phytotherapeutic vegetable extracts and alcoholic beverages. J Chromatogr A 1996;731:336-339.
15. Blais J, Dubertret L, Gaboriau F, Vigny P: Fluorescence detection of an 8-methoxypsoralen metabolite in human interstitial fluid. Photochem Photobiol 1982;35:423-426.
16. Hönigsmann H, Fitzpatrick TB, Pathak MA, Wolff K: Oral photochemotherapy with psoralens and UVA (PUVA): Principles and practice; in Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF (eds): Dermatology in General Medicine. New York, McGraw-Hill, 1993, pp 1728-1754.