Potent CYP3A4 inhibitory constituents of Piper cubeba

Journal of Natural Products

Volumn 68, Issue 1, 2005, Pages 64-68

  Usia, Tepy ^a   Watabe, Tadashi ^a   Kadota, Shigetoshi ^a   Tezuka, Yasuhiro ^a,b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b Toyama Medical and Pharmaceutical University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

(1ALPHA,2BETA,5ALPHA,8ALPHA,10ALPHA) 1,10 EPOXY 2 HYDROXY 3,7(11) GUAIADIEN 12,8 OLIDE; (5 ALPHA,8ALPHA) 2 OXO 1(10),3,7(11) GUAIATRIEN 12,8 OLIDE; 1 (2,4,5 TRIMETHOXYPHENYL) 1,2 PROPANEDIONE; 2,4,5 TRIMETHOXYPHENYLACETONE; 4 HYDROXYCUBEBINONE; 5 METHOXYCLUSIN; ALPHA ASARONE; ALPHA METHYLCUBEBIN; CLUSIN; CUBEBIN; CUBEBININ; CUBEBININOLIDE; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DIHYDROCLUSIN; DIHYDROCUBEBIN; ENZYME INHIBITOR; ETHOXYCLUSIN; HINOKININ; KETOCONAZOLE; LIGNAN DERIVATIVE; MAGNOSALIN; MEDIORESINOL; SESQUITERPENE DERIVATIVE; THUJAPLICATIN TRIMETHYL ETHER; UNCLASSIFIED DRUG; YATEIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME METABOLISM; HUMAN; HUMAN CELL; IC 50; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PIPERACEAE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FRUIT; HUMANS; INDONESIA; INHIBITORY CONCENTRATION 50; KETOCONAZOLE; LIGNANS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PIPER; PLANTS, MEDICINAL; STEREOISOMERISM;

PIPER CUBEBA; PIPERACEAE;

EID: 12944268861     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np0401765     Document Type: Article

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