Pharmacokinetics of α-methyl-L-tryptophan in rhesus monkeys and calculation of the lumped constant for estimating the rate of serotonin synthesis

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 1, 1996, Pages 219-224

  Shoaf, Susan E ^a   Schmall, Bernard ^b  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYLTRYPTOPHAN; SEROTONIN; TRYPTOPHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; DOSE RESPONSE; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SEROTONIN RELEASE;

ANIMALS; BRAIN; MACACA MULATTA; MALE; SEROTONIN; TRYPTOPHAN;

EID: 0030435796     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. BOADLE-BIBER, M. C., CORLEY, K. C., GRAVES, L , PHAN, T.-H. AND ROSECRANS, J.: Increase in the activity of tryptophan hydroxylase from cortex and midbrain of male Fischer 344 rats in response to acute or repeated sound stress. Brain Res. 482: 306-316, 1989
2. DIKSIC, M., NAGAHIRO, S., SOURKES, T. L. AND YAMAMOTO, Y. L.: A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model. J. Cereb. Blood. Flow. Metab. 10: 1-12, 1990.
3. GÁL, E. M. AND CHRISTIANSEN, P. A.: α-Methyltryptophan: Effects on cerebral monooxygenases in vitro and in vivo. J. Neurochem. 24: 89-95, 1975.
4. HAMON, M., BOURGOIN, S. AND ENJALBERT, A.: Biochemical regulatory mechanisms of sertotonergic neurons in the rat brain. Prog. reprod. Biol. 2: 25-40, 1977.
5. HAMON, M., BOURGORA, S., HÉRY, F , TERNAUX, J. P. AND GLOWINSKI, J.: In vivo and in vitro activation of soluble tryptophan hydroxylase from rat brainstem. Nature 260: 61-63, 1976.
6. MADRAS, B. K. AND SOURKES, T. L.: Metabolism of α-methyltryptophan. Biochem. Pharmacol. 14:1499-1506, 1965.
7. MISSAL, K. AND SOURKES, T. L.: Functional cerebral activity of an analogue of serotonin formed in situ. Neurochem. Int. 12: 209-214, 1988.
8. NAGAHIRO, S., TAKADA, A., DIKSIC, M., SOURKES, T., MISSALA, K. AND YAMAMOTO, Y.: A new method to measure brain serotonin synthesis in vivo: II. A practical method tested in normal and lithium-treated rats. J. Cereb. Blood. Flow. Metab. 10: 13-21, 1990.
9. PATLAK, C. S. AND PETTIGREW, K. D.: A method to obtain infusion schedules for prescribed blood concentration time courses. J. Appl. Physiol. 40: 458-463, 1976.
10. ROBERGE, A. G., MISSALA, K. AND SOURKES, T. L.: Alpha-methyltryptophan: Effects on synthesis and degradation of serotonin in the brain. Neuropharmacology 11: 197-209, 1972.
11. SCHIRLIN, D., GERHART, F., HORNSPERGER, J. M., HAMON, M., WAGNER, J. AND JUNG M. J., Synthesis and biological properties of α-mono- and α-difluoromethyl derivative of tryptophan and 5-hydroxytryptophan. J. Med. Chem. 31: 30-36, 1988.
12. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28: 897-916, 1977.
13. SOURKES, T. L.: Alpha-methyltryptophan and its action on tryptophan metabolism. Fed. Proc. 30: 897-903, 1971.
14. VANIER, M., TSUIKI, K., GRDISA, M., WORSLEY, K. AND DIKSIC, M.: Determination of the lumped constant for the α-methyltryptophan method of estimating the rate of serotonin synthesis. J. Neurochem. 64: 624-635, 1995.