SGK1, a potential regulator of c-fms related breast cancer aggressiveness

Clinical and Experimental Metastasis

Volumn 21, Issue 6, 2004, Pages 477-483

  Tangir, Jacob ^a   Bonafé, Nathalie ^a   Gilmore Hebert, Maureen ^a   Henegariu, Octavian ^a   Chambers, Setsuko K ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Breast cancer; c fms; CSF 1; Glucocorticoids SGK1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; COLONY STIMULATING FACTOR 1; DEXAMETHASONE; GLUCOCORTICOID; GLUCOKINASE; GLUCOKINASE 1; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; UNCLASSIFIED DRUG;

BREAST CANCER; CANCER CELL; CONTROLLED STUDY; DNA MICROARRAY; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; GENE MUTATION; HUMAN; HUMAN CELL; ONCOGENE; ONCOGENE C FMS; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL ADHESION; DEXAMETHASONE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, FMS; HUMANS; IMMEDIATE-EARLY PROTEINS; MACROPHAGE COLONY-STIMULATING FACTOR; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 12544260256     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10585-004-4226-8     Document Type: Review

References (31)

1. Jemal A, Murray T, Samuels A et al. Cancer statistics, 2003. CA Cancer J Clin 2003; 53: 5-26.
2. Carter CL, Allen C, Henson DE. Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases. Cancer. 1989; 63: 181-7.
3. Maher MG, Sapi E, Turner B et al. Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence. Clin Cancer Res 1998; 4: 1851-6.
4. Scholl SM, Pallud C, Beuvon F et al. Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. J Natl Cancer Inst 1994; 86: 120-6.
5. Sapi E, Flick MB, Rodov S et al. Independent regulation of invasion and anchorage-independent growth by different autophosphorylation sites of the macrophage colony-stimulating factor 1 receptor. Cancer Res 1996; 56: 5704-12.
6. Chambers SK, Wang Y, Gilmore-Hebert M et al. Post-transcriptional regulation of c-fms proto-oncogene expression by dexamethasone and of CSF-1 in human breast carcinomas in vitro. Steroids 1994; 59: 514-22.
7. Sapi E, Flick MB, Gilmore-Hebert M et al. Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoids. Oncogene 1995; 10: 529-42.
8. Filderman AE, Bruckner A, Kacinski BM et al. Macrophage colony-stimulating factor (CSF-1) enhances invasiveness in CSF-1 receptor-positive carcinoma cell lines. Cancer Res 1992; 52: 3661-6.
9. Azodi M, Roy WJ, Chambers JT et al. Inhibition of invasiveness and motility of ovarian and breast cancer cells by oligomer therapy directed towards the c-fms proto-oncogene. Proc Int Gynecol Cancer Soc 1999.
10. Toy EP, Bonafe N, Savlu A et al. Correlation of tumor phenotype with c-fms proto-oncogene expression in an in vivo intra-peritoneal model for experimental human breast cancer metastasis. Clin Exp Metast, submitted.
11. Sapi E, Flick MB, Rodov S et al. Ets-2 transdominant mutant abolishes anchorage-independent growth and macrophage colony-stimulating factor-stimulated invasion by BT20 breast carcinoma cells. Cancer Res 1998; 58: 1027-33.
12. Park J, Leong ML, Buse P et al. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 1999; 18: 3024-33.
13. Brunet A, Park J, Tran H et al. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 2001; 21: 952-65.
14. Chambers SK. In vitro invasion assays. In Bartlett JMS (ed): Methods in Molecular Medicine. Totowa, New Jersey: Humana Press 2000; 179-86.
15. Webster MK, Goya L, Firestone GL. Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase. J Biol Chem 1993; 268: 11482-5.
16. Webster MK, Goya L, Ge Y et al. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 1993; 13: 2031-40.
17. Mikosz CA, Brickley DR, Sharkey MS et al. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem 2001; 276: 16649-54.
18. Pirkl F, Buchner J. Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. J Mol Biol 2001; 308: 795-806.
19. Hsu YP, Weyler W, Chen S et al. Structural features of human monoamine oxidase A elucidated from cDNA and peptide sequences. J Neurochem 1988; 51: 1321-4.
20. Shinozaki S, Nakamura T, Iimura M et al. Upregulation of Reg 1alpha and GW112 in the epithelium of inflamed colonic mucosa. Gut 2001; 48: 623-9.
21. Agarwal AK, Rogerson FM, Mune T et al. Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase. Genomics 1995; 29: 195-9.
22. Kobayashi T, Deak M, Morrice N et al. Characterization of the structure and regulation of two novel isoforms of serum-and glucocorticoid-induced protein kinase. Biochem J 1999; 344 Pt 1: 189-97.
23. Brickley DR, Mikosz CA, Hagan CR et al. Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1). J Biol Chem 2002; 277: 43064-70.
24. Buse P, Tran SH, Luther E et al. Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways. J Biol Chem 1999; 274: 7253-63.
25. Wang J, Barbry P, Maiyar AC et al. SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am J Physiol Renal Physiol 2001; 280: F303-13.
26. Chambers SK, Ivins CM, Kacinski BM et al. An unexpected effect of glucocorticoids on stimulation of c-fms protooncogene expression in choriocarcinoma cells expressing little glucocorticoid receptor. Am J Obstet Gynecol 2004; 190: 974-85.
27. Leong ML, Maiyar AC, Kim B et al. Expression of the serum-and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J Biol Chem 2003; 278: 5871-82.
28. Bourette RP, Myles GM, Choi JL et al. Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling. EMBO J 1997; 16: 5880-93.
29. Kelley TW, Graham MM, Doseff AI et al. Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. J Biol Chem 1999; 274: 26393-8.
30. Grey A, Chen Y, Paliwal I et al. Evidence for a functional association between phosphatidylinositol 3-kinase and c-src in the spreading response of osteoclasts to colony-stimulating factor-1. Endocrinol 2000; 141: 2129-38.
31. Lee AW, States DJ. Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors. Mol Cell Biol 2000; 20: 6779-98.