Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 30, Issue 9, 2003, Pages 1281-1291

  Mayer Kuckuk, Philipp ^a   Doubrovin, Mikhail ^a   Gusani, Niraj J ^a   Gade, Terence ^a   Balatoni, Julius ^a   Akhurst, Tim ^a   Finn, Ronald ^a   Fong, Yuman ^a   Koutcher, Jason A ^a   Larson, Steven ^a   Blasberg, Ronald ^a   Tjuvajev, Juri Gelovani ^a   Bertino, Joseph R ^a   Banerjee, Debabrata ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Dihydrofolate reductase; Gamma camera; Liver metastases; MicroPET; Molecular imaging

Indexed keywords

DIHYDROFOLATE REDUCTASE; FIALURIDINE; GENE PRODUCT; IODINE 124; IODINE 131; TRIMETREXATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INVASION; COLORECTAL CANCER; CONTROLLED STUDY; DIHYDROFOLATE REDUCTASE HERPES SIMPLEX VIRUS 1 THYMIDINE KINASE FUSION TRANSGENE; DISEASE MODEL; FUSION GENE; GENE EXPRESSION REGULATION; GENE TRANSFER; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; LIVER METASTASIS; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; RAT; RAT STRAIN; SCINTILLATION CAMERA; SCINTISCANNING; TRANSGENE; XENOGRAFT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ARABINOFURANOSYLURACIL; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; FEASIBILITY STUDIES; FOLIC ACID ANTAGONISTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IODINE RADIOISOTOPES; LIVER NEOPLASMS; MALE; NEOPLASM TRANSPLANTATION; ORGAN SPECIFICITY; RADIOPHARMACEUTICALS; RATS; RATS, NUDE; RECOMBINANT FUSION PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDINE KINASE; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS; VIRAL PROTEINS; WHOLE-BODY COUNTING;

EID: 12444341821     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-003-1143-z     Document Type: Article

References (31)

1. Mayer-Kuckuk P, Banerjee D, Kemeny N, Fong Y, Bertino JR. Molecular therapies for colorectal cancer metastatic to the liver. Mol Ther 2002; 5:492-500.
2. Sung MW, Yeh HC, Thung SN, Schwartz ME, Mandeli JP, Chen SH, Woo SL. Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: results of a phase I clinical trial. Mol Ther 2001; 4:182-191.
3. Crystal RG, Hirschowitz E, Lieberman M, Daly J, Kazam E, Henschke C, Yankelevitz D, Kemeny N, Silverstein R, Ohwada A, Russi T, Mastrangeli A, Sanders A, Cooke J, Harvey BG. Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. Hum Gene Ther 1997; 8:985-1001.
4. Barnard DL. Technology evaluation: Sch-58500, Canji. Curr Opin Mol Ther 2000; 2:586-592.
5. Rubin J, Galanis E, Pitot HC, Richardson RL, Burch PA, Charboneau JW, Reading CC, Lewis BD, Stahl S, Akporiaye ET, Harris DT. Phase I study of immunotherapy of hepatic metastases of colorectal carcinoma by direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7. Gene Ther 1997; 4:419-425.
6. Mazzolini G, Qian C, Narvaiza I, Barajas M, Borras-Cuesta F, Xie X, Duarte M, Melero I, Prieto J. Adenoviral gene transfer of interleukin 12 into tumors synergizes with adoptive T cell therapy both at the induction and effector level. Hum Gene Ther 2000; 11:113-125.
7. Chen CT, Lin J, Li Q, Phipps SS, Jakubczak JL, Stewart DA, Skripchenko Y, Forry-Schaudies S, Wood J, Schnell C, Hallenbeck PL. Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin. Hum Gene Ther 2000; 11:1983-1996.
8. Kobaek-Larsen M, Thorup I, Diederichsen A, Fenger C, Hoitinga MR. Review of colorectal cancer and its metastases in rodent models: comparative aspects with those in humans. Comp Med 2000; 50:16-26.
9. Kerbel RS. What is the optimal rodent model for anti-tumor drug testing? Cancer Metastasis Rev 1998; 17:301-304.
10. Mayer-Kuckuk P, Banerjee D, Malhotra S, Doubrovin M, Iwamoto M, Akhurst T, Balatoni J, Bornmann W, Finn R, Larson S, Fong Y, Gelovani Tjuvajev J, Blasberg R, Bertino JR. Cells exposed to antifolates show increased levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression. Proc Natl Acad Sci USA 2002; 99:3400-3405.
11. Ercikan-Abali EA, Banerjee D, Waltham MC, Skacel NE, Scotto KW, Bertino JR. Dihydrofolate reductase protein inhibits its own translation by binding to dihydrofolate reductase mRNA sequences within the coding region. Biochemistry 1997; 36; 12317-12322.
12. Chu E, Takimoto CH, Voeller DM, Grem JL, Allegra CJ. Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro. Biochemistry 1993; 32:4756-4760.
13. Weissleder R, Mahmood U, Molecular imaging. Radiology 2001; 219:316-333.
14. Gambhir SS, Herschman HR, Cherry SR, Barrio JR, Satyamurthy N, Toyokuni T, Phelps ME, Larson SM, Balatoni J, Finn R, Sadelain M, Tjuvajev J, Blasberg R. Imaging transgene expression with radionuclide imaging technologies. Neoplasia 2000; 2:118-138.
15. Tjuvajev JG, Finn R, Watanabe K, Joshi R, Oku T, Kennedy J, Beattie B, Koutcher J, Larson S, Blasberg RG. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res 1996; 56:4087-4095.
16. Tjuvajev JG, Avril N, Oku T, Sasajima T, Miyagawa T, Joshi R, Safer M, Beattie B, DiResta G, Daghighian F, Augensen F, Koutcher J, Zweit J, Humm J, Larson SM, Finn R, Blasberg R. Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res 1998; 58:4333-4341.
17. Sun X, Annala AJ, Yaghoubi SS, Barrio JR, Nguyen KN, Toyokuni T, Satyamurthy N, Namavari M, Phelps ME, Herschman HR, Gambhir SS. Quantitative imaging of gene induction in living animals. Gene Ther 2001; 8:1572-1579.
18. Tjuvajev JG, Stockhammer G, Desai R, Uehara H, Watanabe K, Gansbacher B, Blasberg RG. Imaging the expression of transfected genes in vivo. Cancer Res 1995; 55:6126-6132.
19. 18F]FHBG): a new potential imaging agent for viral infection and gene therapy using PET. Nucl Med Biol 1998; 25:175-180.
20. Tjuvajev JG, Doubrovin M, Akhurst T, Cai S, Balatoni J, Alauddin MM, Finn R, Bornmann W, Thaler H, Conti PS, Blasberg RG. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J Nucl Med 2002; 43: 1072-1083.
21. Abrams DN, Lee YW, Mercer JR, Knaus EE, Wiebe LI. Tumour uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models. IX. Radiolabelled 1-(2′-fluoro-2′-deoxy-beta-D-ribofuranosyl)uracil and 1-(2′-chloro-2′-deoxy-beta-D-ribofuranosyl)uracil. Br J Radiol 1986; 59:263-270.
22. Tjuvajev JG, Chen SH, Joshi A, Joshi R, Guo ZS, Balatoni J, Ballon D, Koutcher J, Finn R, Woo SL, Blasberg RG. Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo. Cancer Res 1999; 59:5186-5193.
23. Yu Y, Annala AJ, Barrio JR, Toyokuni T, Satyamurthy N, Namavari M, Cherry SR, Phelps ME, Herschman HR, Gambhir SS. Quantification of target gene expression by imaging reporter gene expression in living animals. Nat Med 2000; 6:933-937.
24. Longo GS, Izzo J, Gorlick R, Banerjee D, Jhanwar SC, Bertino JR. Characterization and drug sensitivity of four newly established colon adenocarcinoma cell lines to antifolate inhibitors of thymidylate synthase. Oncol Res 2000; 12:309-314.
25. Dorudi S, Sheffield JP, Poulsom R, Northover JM, Hart IR. E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study. Am J Pathol 1993; 142:981-986.
26. Koretz K, Schlag P, Boumsell L, Moller P. Expression of VLA-alpha 2, VLA-alpha 6, and VLA-beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases. Am J Pathol 1991; 138:741-750.
27. Bresalier RS, Hujanen ES, Raper SE, Roll FJ, Itzkowitz SH, Martin GR, Kim YS. An animal model for colon cancer metastasis: establishment and characterization of murine cell lines with enhanced liver-metastasizing ability. Cancer Res 1987; 47:1398-1406.
28. Hoff SD, Matsushita Y, Ota DM, Cleary KR, Yamori T, Hakomori S, Irimura T. Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinoma. Cancer Res 1989; 49:6883-6888.
29. Giavazzi R, Foppolo M, Dossi R, Remuzzi A. Rolling and adhesion of human tumor cells on vascular endothelium under physiological flow conditions. J Clin Invest 1993; 92:3038-3044.
30. Rashidi B, Gamagami R, Sasson A, Sun FX, Geller J, Moossa AR, Hoffman RM. An orthotopic mouse model of remetastasis of human colon cancer liver metastasis. Clin Cancer Res 2000; 6:2556-2561.
31. Nyati MK, Symon Z, Kievit E, Dornfeld KJ, Rynkiewicz SD, Ross BD, Rehemtulla A, Lawrence TS. The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy in an intrahepatic colon cancer model. Gene Ther 2002; 9: 844-849.