N-Methyl-2-[4-(2-methylpropyl)phenyl]-3-(3- methoxy-5-methylpyrazin-2-ylsulfamoyl)benzamide; one of a class of novel benzenesulphonamides which are orally-active, ET(A)-seIective endothelin antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 11, 1997, Pages 1399-1402

  Mortlock, Andrew A ^a   Bath, Colin ^a   Butlin, Roger J ^a   Heys, Christine ^a   Hunt, Sarah J ^a   Reid, Alan C ^a   Sumner, Neil F ^a   Tang, Eric K ^a   Whiting, Elaine ^a   Wilson, Campbell ^a   Wright, Nicola D ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; PRESSOR RESPONSE; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

EID: 0030923065     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00228-X     Document Type: Article

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