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Volumn 4, Issue 1, 1996, Pages 81-90

Synthesis of Hexahydrocyclopentimidazol-2-(1H)-one derivatives displaying selective DP-Receptor agonist properties

Author keywords

[No Author keywords available]

Indexed keywords

5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; BW 480C85; BW 572C85; PROSTACYCLIN; PROSTAGLANDIN D2; PROSTAGLANDIN RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; YBW 587C;

EID: 0029968691     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(95)00173-5     Document Type: Article
Times cited : (23)

References (33)
  • 18
    • 85030191959 scopus 로고    scopus 로고
    • note
    • fs of 18 and 19 are 0.3 and 0.2 (silica, ethyl acetate : methanol, 9:1) respectively.
  • 19
    • 85030190959 scopus 로고    scopus 로고
    • note
    • 6a=8.8 Hz.
  • 20
    • 85030188466 scopus 로고    scopus 로고
    • matrix presented
    • matrix presented
  • 22
    • 85030196760 scopus 로고    scopus 로고
    • note
    • 3a,6a=8.8Hz.
  • 24
    • 85030192035 scopus 로고    scopus 로고
    • note
    • 1H NMR spectra of 31 and 33 were analysed in detail as before and the chemical shifts and coupling constants of the cyclopentane ring protons were similar to those of 35 and 7, respectively.
  • 25
    • 85030187993 scopus 로고    scopus 로고
    • note
    • fs of 31 and 32 are 0.3 and 0.2 (silica, ethyl acetate : methanol, 19:1).
  • 26
    • 85030191985 scopus 로고
    • Some preliminary experimental details for Scheme 2 are given in Eur. Pat. Appl. 458 642 (Chem. Abstr. 1992, 116; 106293b).
    • (1992) Chem. Abstr. , vol.116
  • 27
    • 85030196950 scopus 로고
    • Some preliminary experimental details for Scheme 1 are given in Eur. Pat. Appl. 46 597 (Chem. Abstr. 1982, 97; 144568w).
    • (1982) Chem. Abstr. , vol.97
  • 30
    • 85030192865 scopus 로고    scopus 로고
    • note
    • 2, reflux and purification by the methyl ester). Attempts to obtain 39 by a similar route have so far proved unsuccessful. Preliminary evaluation of 38 indicate it is a weak non-selective DP-agonist.
  • 31
    • 85030193194 scopus 로고    scopus 로고
    • matrix presented
    • matrix presented


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.