Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta

Circulation

Volumn 102, Issue 18, 2000, Pages 2262-2268

  Hiltunen, Mikko O ^a   Laitinen, Marja ^a   Turunen, Mikko P ^a   Jeltsch, Michael ^b   Hartikainen, Juha ^a   Rissanen, Tuomas T ^a   Laukkanen, Johanna ^a   Niemi, Mari ^a   Kossila, Maija ^a   Häkkinen, Tomi P ^a   Kivelä, Antti ^a   Enholm, Berndt ^b   Mansukoski, Hannu ^a   Turunen, Anna Mari ^a   Alitalo, Kari ^b   Ylä Herttuala, Seppo ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Genes; Growth substances; Restenosis; Viruses

Indexed keywords

VASCULOTROPIN;

ADENOVIRUS; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; GENE TRANSFER; INTIMA; NONHUMAN; PRIORITY JOURNAL; RABBIT; RESTENOSIS; TUNICA MEDIA;

EID: 0034739554     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.18.2262     Document Type: Article

References (37)

1. Advances in coronary angioplasty
2. Cardiovascular gene therapy
3. Vascular endothelial growth factor (VEGF) and its receptors
4. Clinical applications of angiogenic growth factors and their inhibitors
5. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
6. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries
7. Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase
8. Vascular endothelial growth factor is a secreted angiogenic mitogen
9. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the FIt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
10. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
11. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
12. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flkl) and VEGF receptor 3 (Flt4)
13. Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3
14. A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain
15. A novel vascular endothelial growth factor encoded by off virus, VEGF-E, mediates angio-genesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-l) receptor tyrosine kinases
16. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery
17. Vascular endothelial growth factor C induces angiogenesis in Vivo
18. Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene
19. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia
20. Gene therapy for myocardial angiogenesis: Initial clinical results with direct myocardial injection of phVEGF(165) as sole therapy for myocardial ischemia
21. Angiogenesis gene therapy: Phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant Severe coronary artery disease
22. Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia
23. Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty
24. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
25. Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses
26. Transfer of 15-1ipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein
27. Induction of in vitro angiogenesis in the endothelial-derived cell line, EA hy926, by ethanol is mediated through PKC and MAPK
28. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions
29. FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
30. Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites
31. Modulation of growth factor action: Implications for the treatment of Cardiovascular diseases
32. Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro
33. Vascular endothelial growth factor: How it transmits its signal
34. Genentech enlightens other angiogenesis programs
35. Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia
36. High adenoviral loads stimulate NF kappaB-dependent gene expression in human vascular smooth muscle cells
37. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors