Skin immune responses to peptide and protein antigen are TLR4 independent

Cellular Immunology

Volumn 226, Issue 2, 2003, Pages 116-123

  Kahlon, Roopjeet ^a   Dutz, Jan P ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Skin Care Center   (Canada)

Author keywords

Cytotoxic T lymphocytes; Rodent; Skin; Tetramer; Toll like receptors

Indexed keywords

ANTIBODY; ANTIGEN; CHOLERA TOXIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; OVALBUMIN; PEPTIDE; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKIN; SKIN INJURY; T LYMPHOCYTE; WILD TYPE;

RODENTIA;

EID: 1242338894     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellimm.2003.11.007     Document Type: Article

References (45)

1. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:2001;135-145.
2. Medzhitov R., Janeway C. Jr. Innate immunity. N. Engl. J. Med. 343:2000;338-344.
3. Bowie A., O'Neill L.A. The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. J. Leukoc. Biol. 67:2000;508-514.
4. Bos J.D. Skin Immune System. 1997;CRC Press, New York.
5. Curry J.L., Qin J.Z., Bonish B., Carrick R., Bacon P., Panella J., Robinson J., Nickoloff B.J. Innate immune-related receptors in normal and psoriatic skin. Arch. Pathol. Lab. Med. 127:2003;178-186.
6. Song P.I., Park Y.M., Abraham T., Harten B., Zivony A., Neparidze N., Armstrong C.A., Ansel J.C. Human keratinocytes express functional CD14 and toll-like receptor 4. J. Invest. Dermatol. 119:2002;424-432.
7. Song P.I., Prado R., Neparidze N., Jaiani L., Wang J., Dotto p., Armstrong C.A., Ansell J.C. The expression of toll-like receptors, MD-2 and CD14 in mouse keratinocytes [abstract]. J. Invest. Dermatol. 121(1):2003;. Abstract 945.
8. Qin J., Curry J.L., Robinson J., Nickoloff B.J. Role for heat shock proteins and innate immune response in psoriasis [abstract]. J. Invest. Dermatol. 119(1):2002;. Abstract 558.
9. Mitsui H., Watanabe T., Saeki H., Fujita H., Asahina A., Tamaki K. Differential expression and function of toll-like receptor in murine Langerhans cells: comparison with splenic dendritic cells [abstract]. J. Invest. Dermatol. 121(1):2003;. Abstract 875.
10. Johnson G.B., Brunn G.J., Kodaira Y., Platt J.L. Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by toll-like receptor 4. J. Immunol. 168:2002;5233-5239.
11. Termeer C., Benedix F., Sleeman J., Fieber C., Voith U., Ahrens T., Miyake K., Freudenberg M., Galanos C., Simon J.C. Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4. J. Exp. Med. 195:2002;99-111.
12. Okamura Y., Watari M., Jerud E.S., Young D.W., Ishizaka S.T., Rose J., Chow J.C., Strauss III J.F. The extra domain A of fibronectin activates toll-like receptor 4. J. Biol. Chem. 276:2001;10229-10233.
13. Breloer M., Dorner B., More S.H., Roderian T., Fleischer B., von Bonin A. Heat shock proteins as "danger signals": eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-gamma production in T cells. Eur. J. Immunol. 31:2001;2051-2059.
14. Asea A., Rehli M., Kabingu E., Boch J.A., Bare O., Auron P.E., Stevenson M.A., Calderwood S.K. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J. Biol. Chem. 277:2002;15028-15034.
15. Ohashi K., Burkart V., Flohe S., Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164:2000;558-561.
16. Biragyn A., Ruffini P.A., Leifer C.A., Klyushnenkova E., Shakhov A., Chertov O., Shirakawa A.K., Farber J.M., Segal D.M., Oppenheim J.J., Kwak L.W. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science. 298:2002;1025-1029.
17. Goldstein D.R., Tesar B.M., Akira S., Lakkis F.G. Critical role of the toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J. Clin. Invest. 111:2003;1571-1578.
18. Glenn G.M., Rao M., Matyas G.R., Alving C.R. Skin immunization made possible by cholera toxin. Nature. 391:1998;851.
19. Glenn G.M., Scharton-Kersten T., Vassell R., Matyas G.R., Alving C.R. Transcutaneous immunization with bacterial ADP-ribosylating exotoxins as antigens and adjuvants. Infect. Immun. 67:1999;1100-1106.
20. Tang D.C., Shi Z., Curiel D.T. Vaccination onto bare skin. Nature. 388:1997;729-730.
21. Kaiserlian D., Etchart N. Epicutaneous and transcutaneous immunization using DNA or proteins. Eur. J. Dermatol. 9:1999;169-176.
22. Kahlon R., Hu Y., Orteu C.H., Kifayet A., Trudeau J.D., Tan R., Dutz J.P. Optimization of epicutaneous immunization for the induction of CTL. Vaccine. 21:2003;2890-2899.
23. Nickoloff B.J., Naidu Y. Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J. Am. Acad. Dermatol. 30:1994;535-546.
24. Wood L.C., Elias P.M., Calhoun C., Tsai J.C., Grunfeld C., Feingold K.R. Barrier disruption stimulates interleukin-1 alpha expression and release from a pre-formed pool in murine epidermis. J. Invest. Dermatol. 106:1996;397-403.
25. Gallucci S., Matzinger P. Danger signals: SOS to the immune system. Curr. Opin. Immunol. 13:2001;114-119.
26. Murphy K.M., Heimberger A.B., Loh D.Y. Induction by antigen of intrathymic apoptosis of CD4. + CD8 + TCRlo thymocytes in vivo Science. 250:1990;1720-1723.
27. Hogquist K.A., Jameson S.C., Heath W.R., Howard J.L., Bevan M.J., Carbone F.R. T cell receptor antagonist peptides induce positive selection. Cell. 76:1994;17-27.
28. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 282:1998;2085-2088.
29. Vogel S.N., Wax J.S., Perera P.Y., Padlan C., Potter M., Mock B.A. Construction of a BALB/c congenic mouse, C. · C3H-Lpsd, that expresses the Lpsd allele: analysis of chromosome 4 markers surrounding the Lps gene Infect. Immun. 62:1994;4454-4459.
30. Kalis C., Kanzler B., Lembo A., Poltorak A., Galanos C., Freudenberg M.A. Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice. Eur. J. Immunol. 33:2003;798-805.
31. Falk K., Rotzschke O., Faath S., Goth S., Graef I., Shastri N., Rammensee H.G. Both human and mouse cells expressing H-2Kb and ovalbumin process the same peptide, SIINFEKL. Cell. Immunol. 150:1993;447-452.
32. Kearney E.R., Pape K.A., Loh D.Y., Jenkins M.K. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1:1994;327-339.
33. Pape K.A., Kearney E.R., Khoruts A., Mondino A., Merica R., Chen Z.M., Ingulli E., White J., Johnson J.G., Jenkins M.K. Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo. Immunol. Rev. 156:1997;67-78.
34. Haskins K., Kubo R., White J., Pigeon M., Kappler J., Marrack P. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J. Exp. Med. 157:1983;1149-1169.
35. Altman J.D., Moss P.A., Goulder P.J., Barouch D.H., McHeyzer-Williams M.G., Bell J.I., McMichael A.J., Davis M.M. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:1996;94-96.
36. Saloga J., Renz H., Larsen G.L., Gelfand E.W. Increased airways responsiveness in mice depends on local challenge with antigen. Am. J. Respir. Crit. Care Med. 149:1994;65-70.
37. Katoh N., Hirano S., Kishimoto S., Yasuno H. Acute cutaneous barrier perturbation induces maturation of Langerhans' cells in hairless mice. Acta Derm. Venereol. 77:1997;365-369.
38. Guler M.L., Gorham J.D., Hsieh C.S., Mackey A.J., Steen R.G., Dietrich W.F., Murphy K.M. Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development. Science. 271:1996;984-987.
39. Klenerman P., Cerundolo V., Dunbar P.R. Tracking T cells with tetramers: new tales from new tools. Nat. Rev. Immunol. 2:2002;263-272.
40. Nishijima T., Tokura Y., Imokawa G., Seo N., Furukawa F., Takigawa M. Altered permeability and disordered cutaneous immunoregulatory function in mice with acute barrier disruption. J. Invest. Dermatol. 109:1997;175-182.
41. Seo N., Tokura Y., Nishijima T., Hashizume H., Furukawa F., Takigawa M. Percutaneous peptide immunization via corneum barrier-disrupted murine skin for experimental tumor immunoprophylaxis. Proc. Natl. Acad. Sci. USA. 97:2000;371-376.
42. Agnese D.M., Calvano J.E., Hahm S.J., Coyle S.M., Corbett S.A., Calvano S.E., Lowry S.F. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J. Infect. Dis. 186:2002;1522-1525.
43. Kawamura Y.I., Kawashima R., Shirai Y., Kato R., Hamabata T., Yamamoto M., Furukawa K., Fujihashi K., McGhee J.R., Hayashi H., Dohi T. Cholera toxin activates dendritic cells through dependence on GM1-ganglioside which is mediated by NF-kappaB translocation. Eur. J. Immunol. 33:2003;3205-3212.
44. Eisenbarth S.C., Piggott D.A., Huleatt J.W., Visintin I., Herrick C.A., Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196:2002;1645-1651.
45. Takeuchi J., Watari E., Shinya E., Norose Y., Matsumoto M., Seya T., Sugita M., Kawana S., Takahashi H. Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells. Biochem. Biophys. Res. Commun. 306:2003;674-679.