Innate and adaptive immune requirements for induction of autoimmune demyelinating disease by molecular mimicry

Molecular Immunology

Volumn 40, Issue 14-15, 2004, Pages 1103-1108

  Olson, Julie K ^a   Croxford, J Ludovic ^a   Miller, Stephen D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Innate immunity; Molecular mimicry; Multiple sclerosis; T cell degeneracy; Theiler's virus

Indexed keywords

CD4 ANTIGEN; EPITOPE; PROTEOLIPID PROTEIN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; AUTOIMMUNE DISEASE; BIOENGINEERING; CROSS REACTION; DEMYELINATING DISEASE; DISEASE ASSOCIATION; DNA FLANKING REGION; HAEMOPHILUS INFLUENZAE; HOST; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; LYMPHOCYTE ACTIVATION; MOLECULAR MIMICRY; MULTIPLE SCLEROSIS; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SEQUENCE ANALYSIS; SUPERINFECTION; T LYMPHOCYTE; TH1 CELL; VIRUS RECOMBINANT;

ANIMALIA; HAEMOPHILUS; HAEMOPHILUS INFLUENZAE; MURINAE; THEILER'S ENCEPHALOMYELITIS VIRUS;

EID: 1242338132     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2003.11.010     Document Type: Article

References (30)

1. Allegretta M., Nicklas J.A., Sriram S., Albertini R.J. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science. 247:1990;718-721.
2. Barnett L.A., Whitton J.L., Wang L.Y., Fujinami R.S. Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis. J. Neuroimmunol. 64:1996;163-173.
3. Bernard C.C., de Rosbo N.K. Immunopathological recognition of autoantigens in multiple sclerosis. Acta Neurol. 13:1991;171-178.
4. Carrizosa A.M., Nicholson L.B., Farzan M., Southwood S., Sette A., Sobel R.A., Kuchroo V.K. Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen. J. Immunol. 161:1998;3307-3314.
5. Fujinami R.S. Can virus infections trigger autoimmune disease? J. Autoimmun. 16:2001;229-234.
6. Fujinami R.S., Oldstone M.B. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science. 230:1985;1043-1045.
7. Gran B., Hemmer B., Vergelli M., McFarland H.F., Martin R. Molecular mimicry and multiple sclerosis: degenerate T-cell recognition and the induction of autoimmunity. Ann. Neurol. 45:1999;559-567.
8. Hemmer B., Fleckenstein B.T., Vergelli M., Jung G., McFarland H., Martin R., Wiesmuller K.H. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone. J. Exp. Med. 185:1997;1651-1659.
9. Horwitz M.S., Bradley L.M., Harbetson J., Krahl T., Lee J., Sarvetnick N. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat. Med. 4:1998;781-786.
10. Kurtzke J.F. Epidemiologic evidence for multiple sclerosis as an infection. Clin. Microbiol. Rev. 6:1993;382-427.
11. Kurtzke, J.F., 1997. The epidemiology of multiple sclerosis. In: Raine, C.S., McFarlin, H.F.T.W.W. (Eds.), Multiple Sclerosis: Clinical and Pathogenetic basis. Chapman and Hall, London, pp. 91-139.
12. Kurtzke J.F., Gudmundsson K.R., Bergmann S. Multiple sclerosis in Iceland. I. Evidence of a postwar epidemic. Neurology. 32:1993;143-150.
13. Kurtzke J.F., Hyllested K. Multiple sclerosis in the Faroe Islands. II. Clinical update, transmission, and the nature of MS. Neurology. 36:1986;307-328.
14. Link H., Baig S., Olsson O., Yu-Ping J., Höjeberg B., Olsson T. Persistent anti-myelin basic protein IgG antibody response in multiple sclerosis cerebrospinal fluid. J. Neuroimmunol. 28:1990;237-248.
15. Lipton H.L. Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination. Infect. Immun. 11:1975;1147-1155.
16. Madsen L.S., Andersson E.C., Jansson L., Krogsgaard M., Andersen C.B., Engberg J., Strominger J.L., Svejgaard A., Hjorth J.P., Holmdahl R., Wucherpfennig K.W., Fugger L. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat. Genet. 23:1999;343-347.
17. Medzhitov R., Janeway C.A. Jr. Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9:1997;4-9.
18. Miller S.D., Vanderlugt C.L., Begolka W.S., Pao W., Yauch R.L., Neville K.L., Katz-Levy Y., Carrizosa A., Kim B.S. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat. Med. 3:1997;1133-1136.
19. Ohashi P.S., Oehen S., Buerki K., Pircher H., Ohashi C.T., Odermatt B., Malissen B., Zinkernagel R.M., Hengartner H. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell. 65:1991;305-317.
20. Oldstone M.B., Nerenberg M., Southern P., Price J., Lewicki H. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell. 65:1991;319-331.
21. Olson J.K., Croxford J.L., Calenoff M., Dal Canto M.C., Miller S.D. A virus-induced molecular mimicry model of multiple sclerosis. J. Clin. Invest. 108:2001a;311-318.
22. Olson J.K., Croxford J.L., Miller S.D. Virus-induced autoimmunity: potential role of viruses in initiation, perpetuation, and progression of T cell-mediated autoimmune diseases. Vir. Immunol. 14:2001b;227-250.
23. Olson J.K., Eagar T.N., Miller S.D. Functional activation of myelin-specific T cells by virus-induced molecular mimicry. J. Immunol. 169:2002;2719-2726.
24. Olson J.K., Girvin A.M., Miller S.D. Direct activation of innate and antigen presenting functions of microglia following infection with Theiler's virus. J. Virol. 75:2001c;9780-9789.
25. Ota K., Matsui M., Milford E.L., Mackin G.A., Weiner H.L., Hafler D.A. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 346:1990;183-187.
26. Sadovnick A.D., Armstrong H., Rice G.P., Bulman D., Hashimoto L., Paty D.W., Hashimoto S.A., Warren S., Hader W., Murray T.J. A population-based study of multiple sclerosis in twins: update. Ann. Neurol. 33:1993;281-285.
27. Scholz C., Patton K.T., Anderson D.E., Freeman G.J., Hafler D.A. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J. Immunol. 160:1998;1532-1538.
28. Steinman L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell. 85:1996;299-302.
29. Sun J.B., Olsson T., Wang W.Z., Xiao B.G., Kostulas V., Fredrikson S., Ekre H.P., Link H. Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur. J. Immunol. 21:1991;1461-1468.
30. Wucherpfennig K.W., Strominger J.L. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:1995;695-705.