Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities

Biochemical Journal

Volumn 377, Issue 3, 2004, Pages 775-779

  Hurst, Douglas R ^a   Schwartz, Martin A ^a   Ghaffari, Mohammad A ^a   Jin, Yonghao ^a   Tschesche, Harald ^b   Fields, Gregg B ^c   Sang, Qing Xiang Amy ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

^b BIELEFELD UNIVERSITY   (Germany)

^c FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

Activation energy; Catalytic domain; Diastereomeric MMP inhibitors; Ecto domain; Membrane type 1 matrix metalloproteinase (MT1 MMP); Substrate specificity

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL MEMBRANES; CATALYSIS; ENZYME INHIBITION; REACTION KINETICS;

TRIPLE-HELICAL PEPTIDE SUBSTRATES;

ENZYMES;

MATRIX METALLOPROTEINASE 14; PROTEINASE;

ARTICLE; DIASTEREOISOMER; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBUNIT; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN HYDROLYSIS; PROTEINASE INHIBITION;

FELIS CATUS;

EID: 1242314741     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj20031067     Document Type: Article

References (27)

1. McCawley, L. J. and Matrisian, L. M. (2001) Matrix metalloproteinases: they're not just for matrix anymore! Curr. Opin. Cell Biol. 13, 534-540
2. Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E. and Seiki, M. (1994) A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature (London) 370, 61-65
3. Li, H., Bauzon, D. E., Xu, X., Tschesche, H., Cao, J. and Sang, Q.-X. A. (1998) Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts. Mol. Carcinogen. 22, 84-94
4. Yana, I. and Weiss, S. J. (2000) Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases. Mol. Biol. Cell. 11, 2387-2401
5. Sternlicht, M. D. and Werb, Z. (2001) How matrix metalloproteinases regulate cell behavior. Annu. Rev. Cell Dev. Biol. 17, 463-516
6. Murphy, G. and Knäuper, V. (1997) Relating matrix metalloproteinase structure to function: why the 'hemopexin' domain? Matrix Biol. 15, 511-518
7. Overall, C. M. (2002) Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites. Mol. Biotech. 22, 51-86
8. Lauer-Fields, J. L., Juska, D. and Fields, G. B. (2002) Matrix metalloproteinases and collagen catabolism. Biopolymers 66, 19-32
9. Mori, H., Tomari, T., Koshikawa, N., Kajita, M., Itoh, Y., Sato, H., Tojo, H., Yana, I. and Seiki, M. (2002) CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. EMBO J. 21, 3949-3959
10. Lehti, K., Lohi, J., Juntunen, M. M., Pei, D. and Keski-Oja, J. (2002) Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase. J. Biol. Chem. 277, 8440-8448
11. Tam, E., Wu, Y. I., Butler, G. S., Stack, M. S. and Overall, C. M. (2002) Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage. J. Biol. Chem. 277, 39005-39014
12. Ohuchi, E., Imai, K., Fujii, Y., Sato, H., Seiki, M. and Okada, Y. (1997) Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J. Biol. Chem. 272, 2446-2451
13. Pei, D. and Weiss, S. J. (1996) Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity. J. Biol. Chem. 271, 9135-9140
14. d'Ortho, M. P., Will, H., Atkinson, S., Butler, G., Messent, A., Gavrilovic, J., Smith, B., Timpl, R., Zardi, L. and Murphy, G. (1997) Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases. Eur. J. Biochem. 250, 751-757
15. Lauer-Fields, J. L., Broder, T., Sritharan, T., Chung, L., Nagase, H. and Fields, G. B. (2001) Kinetic analysis of matrix metalloproteinase activity using fluorogenic triple-helical substrates. Biochemistry 40, 5795-5803
16. Schwartz, M. A. and van Wart, H. E. (1995) Mercaptosulfide metalloproteinase inhibitors. U.S. Patent 5455262
17. Jin, Y., Ghaffari, M. A. and Schwartz, M. A. (2002) A practical synthesis of differentially-protected cis-1,2-cyclopentanedithiols and cis-3,4-pyrrolidinedithiols. Tetrahedron Lett. 43, 7319-7321
18. Lichte, A., Kolkenbrock, H. and Tschesche, H. (1996) The recombinant catalytic domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) induces activation of progelatinase A and progelatinase A complexed with TIMP-2. FEBS Lett. 397, 277-282
19. Roderfeld, M., Büttner, F. H., Bartnik, E. and Tschesche, H. (2000) Expression of human membrane type 1 matrix metalloproteinase in Pichia pastoris. Protein Expr. Purif. 19, 369-374
20. Park, H. I., Ni, J., Gerkema, F. E., Liu, D., Belozerov, V. E. and Sang, Q.-X. A. (2000) Identification and characterization of human endometase (matrix metalloproteinase-26) from endometrial tumour. J. Biol. Chem. 275, 20540-20544
21. Park, H. I., Turk, B. E., Gerkema, F. E., Cantley, L. C. and Sang, Q.-X. A. (2002) Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. J. Biol. Chem. 277, 35168-35175
22. Morrison, J. F. (1969) Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors. Biochim. Biophys. Acta 185, 269-286
23. Riddles, P. W., Blakeley, R. L. and Zerner, B. (1979) Ellman's reagent: 5,5′-dithiobis(2-nitrobenzoic acid) - a re-examination. Anal. Biochem. 94, 75-81
24. Sang, Q.-X. A., Jia, M.-C., Schwartz, M. A., Jaye, M. C., Kleinman, H. K., Ghaffari, M. A. and Luo, Y.-L. (2000) New thiol and sulfodiimine metalloproteinase inhibitors and their effect on human microvascular endothelial cell growth. Biochem. Biophys. Res. Commun. 274, 780-786
25. Itoh, Y., Takamura, A., Ito, N., Maru, Y., Sato, H., Suenaga, N., Aoki, T. and Seiki, M. (2001) Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumour cell invasion. EMBO J. 20, 4782-4793
26. Lauer-Fields, J. L., Tuzinski, K. A., Shimokawa, K., Nagase, H. and Fields, G. B. (2000) Hydrolysis of triple-helical collagen peptide models by matrix metalloproteinases. J. Biol. Chem. 275, 13282-13290
27. Knäuper, V., Löpez-Otin, C., Smith, B., Knight, G. and Murphy G. (1996) Biochemical characterization of human collagenase-3. J. Biol. Chem. 271, 1544-1550