Effects of Rumex patientia root extract on indomethacine and ethanol induced gastric damage in rats

Pharmazie

Volumn 59, Issue 2, 2004, Pages 147-149

  Suleyman H ^a   Demirezer, L Ömür ^b   Kuruuzum Uz A ^b  

^a ATATURK UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANTIOXIDANT; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; FAMOTIDINE; INDOMETACIN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; ROFECOXIB; RUMEX PATIENTIA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; GASTROINTESTINAL TRACT; MALE; NONHUMAN; RAT; RUMEX; STOMACH ACID SECRETION; STOMACH INJURY; STOMACH ULCER;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ETHANOL; INDOMETHACIN; ISOENZYMES; MALE; PLANT EXTRACTS; PLANT ROOTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR; RUMEX; STOMACH ULCER;

EID: 1242314322     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Bjarnason I (1999) NSAIDs are the really devoid of side effects. Ital J Gastroenterol Hepatol 31: 27-36.
2. Buttgereit F, Burmester GR, Simon LS (2001) Gastrointestinal toxic side effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2-specific inhibitors. Am J Med 110: 13-19.
3. Çetinkaya Ö, Siliǧ Y, Çetinkaya S, Demirezer LÖ (2002) The effects of Rumex patientia extract on rat liver and erythrocyte antioxidant enzyme. Pharmazie 57: 487-488.
4. Davis PH (1967) Flora of Turkey and East Aegean Islands. University press, Edinburgh, Vol. 2, p. 281-293.
5. Davis PH (1988) Flora of Turkey and East Aegean Islands. University press, Edinburgh, Vol. 10, p. 86-87.
6. Demirezer LÖ, Kuruüzüm-Uz A, Bergere I, Schiewe HJ, Zeeck A (2001a) Five napthalene glycosides from Rumex patientia. Phytochemistry 56: 399-402.
7. Demirezer LÖ, Kuruüzüm-Uz A, Bergere I, Schiewe HJ, Zeeck A (2001b) The structures of antioxidant and cytotoxic agents from natural source: Anthraquinones and tannins from roots of Rumex patientia. Phytochemistry 58: 1213-1217.
8. Demirezer, LÖ, Kuruüzüm A, Özalp M, Ekizoǧlu M (1999) Antibacterial and antifungal activities of Rumex patientia L. Hacettepe University Journal of Faculty of Pharmacy 19: 57-62.
9. Derek AW, Adrian RM, Paul RCN (2000) Cox1, Cox2, and Cox-3 the future treatment of cronic inflammatory disease. Lancet 335: 646-648.
10. Guidobono F, Pagani F, Ticozzi C, Sibila V (1997) Protection by amylin of gastric erosions induced by indomethacin or ethanol in rate. Br J Pharm 120: 581-586.
11. Kataoka H, Hone Y, Koyama R, Nakatsugi S and Furukava M (2000) Interaction between NSAIDs and steroid in rat stomach. Dig Dis Sci 45: 1366-1375.
12. Kotsinas A, Gorgoulis V, Zacharatos P, Zioris H et al. (1999) Antioxidant agent nimesulid and β-blocker metoprolol do not exert protective effects against rat mitochondrial DNA altertations in adriamycin-induced cardiotoxicity. Biochem Biophys Res Commun 254: 651-656.
13. Kuruüzüm A, Demirezer LÖ, Bergere I, Zeeck A (2001) Two new chlorinated naphthalene glycosides from Rumex patientia. J Nat Prod 64: 688-690.
14. Mitchell JA, Warner TD (1999) Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy. Br J Pharmacol 128: 1121-1132.
15. Smith GS, Mercer DN, Cross JM (1996) Gastric injury induced by ethanol and ishemia-reperfusion in the rat. Dig Dis Sci 41: 1157-1164.
16. Süleyman H, Demirezer LÖ, Kuruüzüm A, Banoǧlu ZN, Göçer F, Özbakir G, Gepdiremen A (1999) Antiinflammatory effect of the aqueous extract from Rumex patientia. J Ethnopharmacol 65: 141-148.
17. Süleyman H, Demirezer LÖ, Kuruüzüm A, Büyükokuroǧlu ME, Göçer F, Banoǧlu ZN, Gepdiremen A (2001a) Effect of the aqueous extract of Rumex patientia on xylol and hyaluronidase induced capillary permeability. Pharmazie 56: 92-93.
18. Süleyman H, Demirezer LÖ, Kuruüzüm-Uz A (2001b) Analgesic and antipyretic activities of Rumex patientia extract on mice and rabbits. Pharmazie 56: 815-817.
19. Süleyman H, Demirezer LÖ, Kuruüzüm A, Akçay F (2002) Gastroprotective effect of Rumex patientia. Pharmazie 57: 204-205.
20. Warner TD, Giluliano F, Vojnovicc I, Bukasa A, Mitchell JA, Vane JR (1999) Nonsteroid drug selectivities for cyclooxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 96: 7563-7568.