N-(2-hydroxypropyl)-methacrylamide copolymer-9-aminocamptothecin conjugate: Colon-specific drug delivery in rats

Journal of Bioactive and Compatible Polymers

Volumn 17, Issue 5, 2002, Pages 305-319

  Sakuma, Shinji ^a   Lu, Zheng rong ^a   Pecharová, Barbara ^a   Kopečková, Pavla ^b   Kopeček, Jindřich ^b  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

Author keywords

Anticancer agents; Bioconjugates; Camptothecin; Colon specific drug delivery; HPMA copolymer

Indexed keywords

CHEMICAL BONDS; DRUG PRODUCTS; PHARMACOKINETICS; SYNTHESIS (CHEMICAL);

DRUG DELIVERY;

COPOLYMERS;

9 AMINOCAMPTOTHECIN; AZO REDUCTASE; LEUCYLALANINE; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; PEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CHEMICAL BINDING; COLON; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG STABILITY; ENZYME ACTIVITY; INTESTINE ABSORPTION; MALE; NONHUMAN; RAT; STOMACH ABSORPTION;

ANIMALIA;

EID: 0036763519     PISSN: 08839115     EISSN: None     Source Type: Journal    
DOI: 10.1177/0883911502017005557     Document Type: Article

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