Association between single-nucleotide polymorphisms in the endothelial lipase (LIPG) gene and high-density lipoprotein cholesterol levels

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1636, Issue 1, 2004, Pages 40-46

  Mank Seymour, Amy R ^a   Durham, Kathryn L ^a   Thompson, John F ^a   Seymour, Albert B ^a   Milos, Patrice M ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Association study; Genetics; Lipid

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN LIPASE; LIVER TRIACYLGLYCEROL LIPASE; TRIACYLGLYCEROL LIPASE;

ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENDOTHELIAL LIPASE GENE; ENZYME ACTIVITY; GENE; GENE FUNCTION; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; INTRON; LIPID ABSORPTION; LIPID METABOLISM; LIPID TRANSPORT; LIPOPROTEIN BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 1242292260     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2003.12.001     Document Type: Article

References (20)

1. Gordon D.J., Rifkind B.M. High-density lipoprotein-the clinical implications of recent studies. N. Engl. J. Med. 321:1989;1311-1316.
2. Rader D.J. High-density lipoproteins and atherosclerosis. Am. J. Cardiol. 90:2002;62i-70i.
3. Tangirala R.K., Tsukamoto K., Chun S.H., Usher D., Puré E., Rader D.J. Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice. Circulation. 100:1999;1816-1822.
4. Tsukamoto K., Tangirala R., Chun S.H., Puré E., Rader D.J. Rapid regression of atherosclerosis induced by liver-directed gene transfer of ApoE in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 19:1999;2162-2167.
5. Rader D.J., Maugeais C. Genes influencing HDL metabolism: new perspectives and implications for atherosclerosis prevention. Mol. Med. Today. 6:2000;170-175.
6. Jaye M., Lynch K.J., Krawiec J., Marchadier D., Maugeais C., Doan K., South V., Amin D., Perrone M., Rader D.J. A novel endothelial-derived lipase that modulates HDL metabolism. Nat. Genet. 21:1999;424-428.
7. Hirata K., Dichek H.L., Cioffi J.A., Choi S.Y., Leeper N.J., Quintana L., Kronmal G.S., Cooper A.D., Quertermous T. Cloning of a unique lipase from endothelial cells extends the lipase gene family. J. Biol. Chem. 274:1999;14170-14175.
8. Rader D.J., Jaye M. Endothelial lipase: a new member of the triglyceride lipase gene family. Curr. Opin. Lipidol. 11:2000;141-147.
9. Ishida T., Choi S., Kundu R.K., Hirata K., Rubin E.M., Cooper A.D., Quertermous T. Endothelial lipase is a major determinant of HDL level. J. Clin. Invest. 111:2003;347-355.
10. Jin W., Millar J.S., Broedl U., Glick J.M., Rader D.J. Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo. J. Clin. Invest. 111:2003;357-362.
11. Ma K., Cilingiroglu M., Otvos J.D., Ballantyne C.M., Marian A.J., Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc. Natl. Acad. Sci. U. S. A. 100:2003;2748-2753.
12. deLemos A.S., Wolfe M.L., Long C.J., Sivapackianathan R., Rader D.J. Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol. Circulation. 106:2002;1321-1326.
13. Ballantyne C.M., Andrews T.C., Hsia J.A., Kramer J.H., Shear C. Correlation of non-high-density lipoprotein cholesterol with apolipoprotein B: effect of 5 hydroxymethylglutaryl coenzyme A reductase inhibitors on non-high-density lipoprotein cholesterol levels. Am. J. Cardiol. 88:2001;265-269.
14. Stephens J.C., Schneider J.A., Tanguay D.A., Choi J., Acharya T., Stanley S.E., Jiang R., Messer C.J., Chew A., Han J., Duan J., Carr J.L., Lee M.S., Koshy B., Kumar A.M., Zhang G., Newell W.R., Windemuth A., Xu C., Kalbfleisch T.S., Shaner S.L., Arnold K., Schulz V., Drysdale C.M., Nandabalan K., Judson R.S., Ruaño G., Vovis G.F. Haplotype variation and linkage disequilibrium in 313 human genes. Science. 293:2001;489-493.
15. Nickerson D.A., Tobe V.O., Taylor S.L. PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing. Nucleic Acids Res. 25:1997;2745-2751.
16. Slatkin M., Excoffier L. Testing for linkage disequilibrium in genotypic data using the expectation-maximization algorithm. Heredity. 76:1996;377-383.
17. Heller D.A., de Faire U., Pedersen N.L., Dahlen G., McClearn G.E. Genetic and environmental influences on serum lipid levels in twins. N. Engl. J. Med. 328:1993;1150-1156.
18. Hokanson J.E. Functional variants in the lipoprotein lipase gene and risk cardiovascular disease. Curr. Opin. Lipidol. 10:1999;393-399.
19. Deeb S.S., Peng R. The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity. J. Lipid Res. 41:2000;155-158.
20. Cohen J.C., Vega G.L., Grundy S.M. Hepatic lipase: new insights from genetic and metabolic studies. Curr. Opin. Lipidol. 10:1999;259-267.