Local and controlled release of growth factors (combination of IGF-I and TGF-beta I, and BMP-2 alone) from a polylactide coating of titanium implants does not lead to ectopic bone formation in sheep muscle

Journal of Controlled Release

Volumn 95, Issue 2, 2004, Pages 249-256

  Wildemann, B ^a   Kandziora, F ^a   Krummrey, G ^a   Palasdies, N ^a   Haas, N P ^a   Raschke, M ^b   Schmidmaier, G ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Ectopic ossification; Growth factors; Muscle; Polylactide; Soft tissue capsule

Indexed keywords

CELLS; HISTOLOGY; IMPLANTS (SURGICAL); MUSCLE; ORGANIC POLYMERS; ORTHOPEDICS; TITANIUM;

DRUG CARRIERS; ORTHOPEDIC IMPLANTS;

BONE;

BONE MORPHOGENETIC PROTEIN 2; POLYLACTIDE; SOMATOMEDIN C; TITANIUM; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; FEMALE; FOLLOW UP; FRACTURE HEALING; HETEROTOPIC OSSIFICATION; HISTOLOGY; IMPLANTATION; MATERIAL COATING; MORPHOMETRICS; MUSCULUS CLEIDOMASTOIDEUS; NONHUMAN; ORTHOPEDIC EQUIPMENT; OSSIFICATION; PLATE FIXATION; POSTOPERATIVE CARE; PRIORITY JOURNAL; RADIOLOGY; SHEEP; SOFT TISSUE; STERNOCLEIDOMASTOID MUSCLE; X RAY ANALYSIS;

EID: 1242271291     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2003.11.014     Document Type: Article

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