Osteoinduction by recombinant human bone morphogenetic protein-2 at intramuscular, intermuscular, subcutaneous and intrafatty sites

International Journal of Oral and Maxillofacial Surgery

Volumn 29, Issue 1, 2000, Pages 62-66

  Okubo, Yasunori ^a   Bessho, Kazuhisa ^a   Fujimura, Kazuma ^a   Konishi, Yasuzo ^a   Kusumoto, Kenji ^b   Ogawa, Yutaka ^b   Iizuka, Tadahiko ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Bone formation; Osteoinduction; Recombinant human bone morphogenetic protein 2

Indexed keywords

EID: 0034134364     PISSN: 09015027     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0020.2000.290114.x     Document Type: Article

References (20)

1. BASSETT CAL. Current concepts of bone formation. J Bone Joint Surg 1962: 44A: 1217-44.
2. BOYNE PJ. Animal studies of application of rhBMP-2 in maxillofacial reconstruction. Bone 1996: 19: 83-92.
3. CONNETRY HV, BRIGGS AR. Determination of serum calcium by means of orthocresolphthalein complexone. Am J Clin Pathol 1966: 45: 290-6.
4. FUJIMURA K, BESSHO K, KUSUMOTO K, OGAWA Y, IIZUKA T. Experimental studies on bone inducing activity of composites of atelopeptide type I collagen as a carrier for ectopic osteoinduction by rhBMP-2. Biochem Biophys Res Commun 1995: 208: 316-22.
5. FUJIMURA K, BESSHO K, KUSUMOTO K, KONISHI Y, OGAWA Y, IIZUKA T. Osteoinduction by rhBMP-2 in low-blood supply tissue. (Submitted).
6. GREENBLATT EP, LOEB AL, LONGNECKER DE. Marked regional heterogeneity in the magnitude of EDRF/NO-mediated vascular tone in awake rats. J Cardiovasc Pharmacol 1993: 21: 235-40.
7. KÜBLER NR, REUTHER JF, FALLER G, KIRCHNER T, RUPPORT R, SEBALD W. Inductive properties of recombinant human BMP-2 produced in a bacterial expression system. Int J Oral Maxillofac Surg 1998: 27: 305-9.
8. MAINOUS EG. Hyperbaric oxygen in maxillofacial osteomyelitis, osteoradionecrosis, and osteogenesis enhancement. In: Hyperbaric Oxygen Therapy. Bethesda: Undersea Medical Society Inc., 1977.
9. MURATA M, INOUE M, ARISUE M, KUBOKI N, NAGAI N. Carrier-dependency of cellular differentiation induced by bone morphogenetic protein in ectopic sites. Int J Oral Maxillofac Surg 1998: 27: 391-6.
10. OKUBO Y, BESSHO K, FUJIMURA K, et al. Comparative study of intramuscular and intraskeletal osteogenesis by recombinant human bone morphogenetic protein-2. Oral Surg 1999: 87: 34-8.
11. OMURA S, MIZUKI N, KAWABE R, OTA R, KOBAYASHI S, FUJITA K. A carrier for clinical use of recombinant human BMP-2: dehydrothermally cross-linked composite of fibrillar and denatured atelocollagen sponge. Int J Oral Maxillofac Surg 1998: 27: 129-34.
12. RUPPERT R, HOFFMANN E, SEBALD W. Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity. Eur J Biochem 1996: 237: 295-302.
13. SHAW JK, BASSETT CAL. The effect of varying oxygen concentrations on osteogenesis and embryonic cartilage in vitro. J Bone Joint Surg 1967: 49A: 73-80.
14. SI X, JIN Y, YANG L. Induction of new bone by ceramic bovine bone with recombinant human bone morphogenetic protein 2 and transforming growth factor. Int J Oral Maxillofac Surg 1998: 27: 310-4.
15. TAYLOR SM, JONES PA. Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell 1979: 17: 771-9.
16. THE EXECUTIVE BOARD AND THE COMMITTEE FOR ENZYMES IN THE ANALYTICAL SECTION OF THE JAPAN SOCIETY OF CLINICAL CHEMISTRY (JSCC). Provisional recommendation for measurement of catalytic concentration of alkaline phosphatase in serum. JSCC 1988: 1: 11-9.
17. URIST MR, HUO YK, BROWNELL AG, et al. Purification of bovine bone morphogenetic protein by hydroxyapatite chromatography. Proc Natl Sci U S A 1994: 81: 371-5.
18. WOZNEY JM, ROSEN V, CELESTE AJ, et al. Novel regulators of bone formation: molecular clones and activities. Science 1988: 242: 1528-34.
19. YAMAGUCHI A, KATAGIRI T, IKEDA T, et al. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 1991: 113: 681-7.
20. YOSHIDA K, BESSHO K, FUJIMURA K, et al. Osteoinduction capability of recombinant human bone morphogenetic protein-2. J Craniomaxillofac Surg 1998: 26: 112-5.