White blood count as a predictor of glucose tolerance and insulin sensitivity: The role of inflammation in the pathogenesis of type 2 diabetes;Die Leukozytenzahl als Prädiktor für Glukosetoleranz und Insulinsensitivität: Rolle der Entzündung in der Pathogenese des Typ-2-Diabetes mellitus

Deutsche Medizinische Wochenschrift

Volumn 129, Issue 6, 2004, Pages 244-248

  Fritsche, A ^a,b   Haring H ^a   Stumvoll, M ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INFLAMMATION; INSULIN RELEASE; INSULIN SENSITIVITY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PATHOGENESIS; SEX; STATISTICAL ANALYSIS;

EID: 1242269924     PISSN: 00120472     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-817997     Document Type: Article

References (26)

1. Crook MA, Tutt P, Simpson H et al. Serum sialic acid and acute phase proteins in type 1 and type 2 diabetes mellitus. Clin Chim Acta 1993; 219: 131-138
2. Fernandez-Real JM, Broch M, Vendrell J et al. Interleukin-6 gene polymorphism and insulin sensitivity. Diabetes 2000; 49: 517-520
3. Fernandez-Real JM, Ricart W. Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/pheno-type to thriftiness. Diabetologia 1999; 42: 1367-1374
4. Fernandez-Real JM, Vayreda M, Richart C et al. Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J Clin Endocrinol Metab 2001; 86: 1154-1159
5. Ferrannini E, Natali A, Bell P et al. Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest 1997; 100: 1166-1173
6. Festa A, D'Agostino RJ, Howard G et al. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000; 102: 42-47
7. Hundal RS, Petersen KF, Mayerson AB et al. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest 2002; 109: 1321-1326
8. Lindsay RS, Krakoff J, Hanson RL et al. Gamma globulin levels predict type 2 diabetes in the Pima Indian population. Diabetes 2001; 50: 1598-1603
9. Matsuda A, DeFronzo R. Insulin sensitivity indices obtained from oral glucose tolerance testing. Diab Care 1999; 22: 1462-1470
10. Mohamed-Ali V, Goodrick S, Rawesh A et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 1997; 82: 4196-4200
11. Nosadini R, Del Prato S, Tiengo A et al. Insulin resistance in Cushing's syndrome. J Clin Endocrinol Metab 1983; 57: 529-536
12. Pankow JS, Folsom AR, Cushman M et al. Familial and genetic determinants of systemic markers of inflammation: the NHLB1 family heart study. Atherosclerosis 2001; 154: 681-689
13. Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 1998; 41: 1241-1248
14. Pratley RE, Wilson C, Bogardus C. Relation of the white blood cell count to obesity and insulin resistance: effect of race and gender. Obes Res 1995; 3: 563-571
15. Saghizadeh M, Ong JM, Garvey WT et al. The expression of TNF alpha by human muscle: Relationship to insulin resistance. J Clin Invest 1996; 97: 1111-1116
16. Schmidt MI, Duncan BB, Sharrett AR et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 1999; 353: 1649-1652
17. Spranger J, Kroke A, Mohlig M et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003; 361: 226-228
18. Stumvoll M, Fritsche A, Häring H. Clinical characterization of insulin secretion as basis for genetic analyses. Diabetes 2002; 51: S122-S129
19. Stumvoll M, Mitrakou A, Pimenta W et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diab Care 2000; 23: 295-301
20. Thamer C, Stumvoll M, Niess A et al. Reduced skeletal muscle oxygen uptake and reduced beta cell function - two early abnormalities in normal glucose tolerant offspring of patients with type 2 diabetes. Diabetes Care 2003; 26: 2126-2132
21. Tschritter O, Fritsche A, Thamer C et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 2003; 52: 239-243
22. Vozarova B, Weyer C, Hanson K et al. Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res 2001; 9: 414-417
23. Vozarova B, Weyer C, Lindsay RS et al. High white blood cell count is associated with a worsening of insulin sensitivity and predicts the developement of type 2 diabetes. Diabetes 2002; 51: 455-461
24. Weyer C, Tataranni PA, Pratley RE. Insulin action and insulinemia are closely related to the fasting complement C3, but not acylation stimulating protein concentration. Diabetes Care 2000; 23: 779-785
25. Yuan M, Konstantopoulos N, Lee J et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of lkkbeta. Science 2001; 293: 1673-1677
26. Yudkin JS, Kumari M, Humphries SE et al. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000; 148: 209-214