Idiopathic pulmonary hemosiderosis in adults

Clinical Pulmonary Medicine

Volumn 12, Issue 1, 2005, Pages 16-25

  Ioachimescu, Octavian C ^a,c   Kotch, Arthur ^b   Stoller, James K ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b YALE UNIVERSITY   (United States)

^c NONE   (United States)

Author keywords

Adults; Diffuse alveolar hemorrhage; Idiopathic pulmonary hemosiderosis; Immunosuppressive agents; Iron metabolism; Pulmonary fibrosis

Indexed keywords

CORTICOSTEROID; HEMOSIDERIN; IMMUNOSUPPRESSIVE AGENT; TRANSFERRIN;

ADULT; ANEMIA; CLINICAL FEATURE; COUGHING; DISEASE EXACERBATION; DYSPNEA; HEMOCHROMATOSIS; HEMOPTYSIS; HUMAN; LUNG HEMORRHAGE; LUNG HEMOSIDEROSIS; LUNG INFILTRATE; LUNG LAVAGE; REVIEW; SIDEROSIS; SPUTUM EXAMINATION;

EID: 12344328345     PISSN: 10680640     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.cpm.0000151455.26383.84     Document Type: Review

References (116)

1. Dorland's Illustrated Medical Dictionary. 30th ed. Philadelphia: Saunders; 2003.
2. Stedman's Medical Dictionary. 27th ed. Baltimore: Lippincott, Williams and Wilkins; 2000.
3. Sherman JM, Winnie G, Thomassen MJ, et al. Time course of hemosiderin production and clearance by human pulmonary macrophages. Chest. 1984;86:409-411.
4. Epstein CE, Elidemir O, Colasurdo GN, et al. Time course of hemosiderin production by alveolar macrophages in a murine model. Chest. 2001;120:2013-2020.
5. Ghio AJ, Richards JH, Crissman KM, et al. Iron disequilibrium in the rat lung after instilled blood. Chest. 2000;118:814-823.
6. Virchow R. Die krankhaften Geschwulste. Berlin: August Hirschwald; 1864;26-240.
7. Ceelen W. Die kreislaufstorungen der Lungen. In: Henke L, Lubarch O, eds. Handbuch Der Speziellen Pathologischen Anatomie Und Histologie. Vol. 3. Berlin: Julius Springer; 1931:1-163.
8. Waldenstrom J. Relapsing, diffuse, pulmonary bleeding or hemosiderosis pulmonum: a new clinical diagnosis. Acta Radiol. 1944;25:33-42.
9. Heiner D. Pulmonary hemosiderosis. In: Chernick V, Kendig EL Jr, eds. Disorders of the Respiratory Tract in Children. Philadelphia: WB Saunders; 1990:498-509.
10. Morgan PG, Turner-Warwick M. Pulmonary haemosiderosis and pulmonary haemorrhage. Br J Dis Chest. 1981;75:225-242.
11. Soergel K, Sommers SC. Idiopathic pulmonary hemosiderosis and related syndromes. Am J Med. 1962;32:499-511.
12. Bronson SM. Idiopathic pulmonary hemosiderosis in adults: report of a case and review of the literature. Am J Roentgenol Radium Ther Nucl Med. 1960;83:260-273.
13. Beckerman RC, Taussig LM, Pinnas JL. Familial idiopathic pulmonary hemosiderosis. Am J Dis Child. 1979;133:609-611.
14. Thaell JF, Greipp PR, Stubbs SE, et al. Idiopathic pulmonary hemosiderosis: two cases in a family. Mayo Clin Proc. 1978;53:113-118.
15. Hyatt RW, Adelstein ER, Halazun JF, et al. Ultrastructure of the lung in idiopathic pulmonary hemosiderosis. Am J Med. 1972;52:822-829.
16. Yeager H Jr, Powell D, Weinberg RM, et al. Idiopathic pulmonary hemosiderosis: ultrastructural studies and responses to azathioprine. Arch Intern Med. 1976;136:1145-1149.
17. Dolan CJ Jr, Srodes CH, Duffy FD. Idiopathic pulmonary hemosiderosis: electron microscopic, immunofluorescent, and iron kinetic studies. Chest. 1975;68:577-580.
18. Corrin B, Jagusch M, Dewar A, et al. Fine structural changes in idiopathic pulmonary haemosiderosis. J Pathol. 1987;153:249-256.
19. Gonzalez-Crussi F, Hull MT, Grosfeld JL. Idiopathic pulmonary hemosiderosis: evidence of capillary basement membrane abnormality. Am Rev Respir Dis. 1976;114:689-698.
20. Elliott ML, Kuhn C. Idiopathic pulmonary hemosiderosis: ultrastructural abnormalities in the capillary walls. Am Rev Respir Dis. 1970;102:895-904.
21. Irwin RS, Cottrell TS, Hsu KC, et al. Idiopathic pulmonary hemosiderosis: an electron microscopic and immunofluorescent study. Chest. 1974;65:41-45.
22. Donald KJ, Edwards RL, McEvoy JD. Alveolar capillary basement membrane lesions in Goodpasture's syndrome and idiopathic pulmonary hemosiderosis. Am J Med. 1975;59:642-649.
23. Blanco A, Solis P, Gomez S, et al. Clq-binding immune complexes and other immunological studies in children with pulmonary hemosiderosis. Allergol Immunopathol (Madr). 1984;12:37-44.
24. Le Clainche L, Le Bourgeois M, Fauroux B, et al. Long-term outcome of idiopathic pulmonary hemosiderosis in children. Medicine (Baltimore). 2000;79:318-326.
25. Iijima N, Torii Y, Ito S, et al. [A case of idiopathic pulmonary hemosiderosis recurrent after remission of fifteen years and associated with Sjogren's syndrome]. Nihon Kyobu Shikkan Gakkai Zasshi. 1988;26:1191-1194.
26. Lemley DE, Katz P. Rheumatoid-like arthritis presenting as idiopathic pulmonary hemosiderosis: a report and review of the literature. J Rheumatol. 1986;13:954-957.
27. Heiner D, Sears J, Kniker W. Multiple precipitins to cow milk in chronic respiratory disease. Am J Dis Child. 1962;103:634-654.
28. Boat TF, Polmar SH, Whitman V, et al. Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulmonale secondary to nasopharyngeal obstruction. J Pediatr. 1975;87:23-29.
29. Torres MJ, Giron MD, Corzo JL, et al. Release of inflammatory mediators after cow's milk intake in a newborn with idiopathic pulmonary hemosiderosis. J Allergy Clin Immunol. 1996;98:1120-1123.
30. Milman N, Pedersen FM. Idiopathic pulmonary haemosiderosis: epidemiology, pathogenic aspects and diagnosis. Respir Med. 1998;92:902-907.
31. Wright PH, Menzies IS, Pounder RE, et al. Adult idiopathic pulmonary haemosiderosis and coeliac disease. Q J Med. 1981;50:95-102.
32. Hemoptysis, pulmonary infiltrates, and diarrhea in a 36-year-old man. Am J Med. 1986;80:930-938.
33. Reading R, Watson JG, Platt JW, et al. Pulmonary haemosiderosis and gluten. Arch Dis Child. 1987;62:513-515.
34. Mah MW, Priel IE, Humen DP, et al. Idiopathic pulmonary hemosiderosis, complete heart block and celiac disease. Can J Cardiol. 1989;5:191-194.
35. Pacheco A, Casanova C, Fogue L, et al. Long-term clinical follow-up of adult idiopathic pulmonary hemosiderosis and celiac disease. Chest. 1991;99:1525-1526.
36. Perelman S, Dupuy C, Bourrillon A. [The association of pulmonary hemosiderosis and celiac disease: apropos of a new case in a child]. Ann Pediatr (Paris). 1992;39:185-188.
37. Ploier R, Emhofer J, Dorninger L, et al. [Immunological aspects of a child with idiopathic pulmonary hemosiderosis and celiac disease]. Klin Padiatr. 1998;210:409-412.
38. Rieu D, Ariole P, Lesbros D, et al. [Idiopathic pulmonary hemosiderosis and celiac disease in a child: case report]. Presse Med. 1983;12:2931-2933.
39. Cohen S. Idiopathic pulmonary hemosiderosis. Am J Med Sci. 1999;317:67-74.
40. Cassimos CD, Chryssanthopoulos C, Panagiotidou C. Epidemiologic observations in idiopathic pulmonary hemosiderosis. J Pediatr. 1983;102:698-702.
41. Kayser K, Plodziszewska M, Waitr E, et al. Diffuse pulmonary hemosiderosis after exposure to pesticides: a case report. Respiration. 1998;65:214-218.
42. Acute pulmonary hemorrhage/hemosiderosis among infants: Cleveland, January 1993-November 1994. MMWR Morb Mortal Wkly Rep. 1994;43:881-883.
43. Centers for Disease Control and Prevention. Acute pulmonary hemorrhage/hemosiderosis among infants: Cleveland, January 1993-November 1994. JAMA. 1995;273:281-282.
44. Update: pulmonary hemorrhage/hemosiderosis among infants: Cleveland, Ohio, 1993-1996. MMWR Morb Mortal Wkly Rep. 1997;46:33-35.
45. Update: pulmonary hemorrhage/hemosiderosis among infants: Cleveland, Ohio, 1993-1996. MMWR Morb Mortal Wkly Rep. 2000;49:180-184.
46. Centers for Disease Control and Prevention. Update: pulmonary hemorrhage/hemosiderosis among infants: Cleveland, Ohio, 1993-1996. JAMA. 2000;283:1951-1953.
47. Centers for Disease Control and Prevention. Pulmonary hemorrhage in infants. JAMA. 2001;286:786.
48. Montana E, Etzel RA, Allan T, et al. Environmental risk factors associated with pediatric idiopathic pulmonary hemorrhage and hemosiderosis in a Cleveland community. Pediatrics. 1997;99:E5.
49. Etzel RA, Montana E, Sorenson WG, et al. Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi. Arch Pediatr Adolesc Med. 1998;152:757-762.
50. Dearborn DG, Smith PG, Dahms BB, et al. Clinical profile of 30 infants with acute pulmonary hemorrhage in Cleveland. Pediatrics. 2002;110:627-637.
51. Dearborn DG, Yike I, Sorenson WG, et al. Overview of investigations into pulmonary hemorrhage among infants in Cleveland, Ohio. Environ Health Perspect. 1999;107(suppl 3):495-499.
52. Jarvis BB, Sorenson WG, Hintikka EL, et al. Study of toxin production by isolates of Stachybotrys chartarum and Memnoniella echinata isolated during a study of pulmonary hemosiderosis in infants. Appl Environ Microbiol. 1998;64:3620-3625.
53. Hodgson MJ, Morey P, Leung WY, et al. Building-associated pulmonary disease from exposure to Stachybotrys chartarum and Aspergillus versicolor. J Occup Environ Med. 1998;40:241-249.
54. Vesper SJ, Dearborn DG, Yike I, et al. Hemolysis, toxicity, and randomly amplified polymorphic DNA analysis of Stachybotrys chartarum strains. Appl Environ Microbiol. 1999;65:3175-3181.
55. Vesper SJ, Dearborn DG, Elidemir O, et al. Quantification of siderophore and hemolysin from Stachybotrys chartarum strains, including a strain isolated from the lung of a child with pulmonary hemorrhage and hemosiderosis. Appl Environ Microbiol. 2000;66:2678-2681.
56. Vesper SJ, Vesper MJ. Stachylysin may be a cause of hemorrhaging in humans exposed to Stachybotrys chartarum. Infect Immun. 2002;70:2065-2069.
57. Fillet G, Beguin Y, Baldelli L. Model of reticuloendothelial iron metabolism in humans: abnormal behavior in idiopathic hemochromatosis and in inflammation. Blood. 1989;74:844-851.
58. Hirata T, Bitterman PB, Mornex JF, et al. Expression of the transferrin receptor gene during the process of mononuclear phagocyte maturation. J Immunol. 1986;136:1339-1345.
59. Mateos F, Brock JH, Perez-Arellano JL. Iron metabolism in the lower respiratory tract. Thorax. 1998;53:594-600.
60. Wyllie JC. A study of ferritin iron formation in the rabbit alveolar macrophage. Exp Cell Res. 1973;78:98-102.
61. Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 2000;275:19906-19912.
62. Liu XB, Hill P, Haile DJ. Role of the ferroportin iron-responsive element in iron and nitric oxide dependent gene regulation. Blood Cells Mol Dis. 2002;29:315-326.
63. Harris ZL, Durley AP, Man TK, et al. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci U S A. 1999;96:10812-10817.
64. Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A. 2001;98:8780-8785.
65. Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002;99:4596-4601.
66. Custer G, Balcerzak S, Rinehart J. Human macrophage hemoglobin-iron metabolism in vitro. Am J Hematol. 1982;13:23-36.
67. Gruenheid S, Pinner E, Desjardins M, et al. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J Exp Med. 1997;185:717-730.
68. McGowan SE, Parenti CM, Hoidal JR, et al. Ascorbic acid content and accumulation by alveolar macrophages from cigarette smokers and nonsmokers. J Lab Clin Med. 1984;104:127-134.
69. Castranova V, Bowman L, Miles PR, et al. Toxicity of metal ions to alveolar macrophages. Am J Ind Med. 1980;1:349-357.
70. Egan JJ, Martin N, Hasleton PS, et al. Pulmonary interstitial fibrosis and haemosiderin-laden macrophages: late following heart transplantation. Respir Med. 1996;90:547-551.
71. Ghadially FN. Invited review: the technique and scope of electron-probe X-ray analysis in pathology. Pathology. 1979;11:95-110.
72. Wesselius LJ, Flowers CH, Skikne BS. Alveolar macrophage content of isoferritins and transferrin: comparison of nonsmokers and smokers with and without chronic airflow obstruction. Am Rev Respir Dis. 1992;145:311-316.
73. Baz MA, Ghio AJ, Roggli VL, et al. Iron accumulation in lung allografts after transplantation. Chest. 1997;112:435-439.
74. Breckenridge RL Jr, Ross JS. Idiopathic pulmonary hemosiderosis: a report of familial occurrence. Chest. 1979;75:636-639.
75. Walters GO, Miller FM, Worwood M. Serum ferritin concentration and iron stores in normal subjects. J Clin Pathol. 1973;26:770-772.
76. Danel C, Israel-Biet D, Costabel U, et al. The clinical role of BAL in pulmonary haemorrhages. Eur Respir J. 1990;3:951-959.
77. Danel C, Le Bourgeois M, De Blic J, et al. [Anatomoclinical approach in idiopathic pulmonary hemosiderosis: apropos of 12 cases]. Arch Anat Cytol Pathol. 1989;37:160-165.
78. Grebski E, Hess T, Hold G, et al. Diagnostic value of hemosiderin-containing macrophages in bronchoalveolar lavage. Chest. 1992;102:1794-1799.
79. Perez-Arellano JL, Losa Garcia JE, Garcia Macias MC, et al. Hemosiderin-laden macrophages in bronchoalveolar lavage fluid. Acta Cytol. 1992;36:26-30.
80. Allue X, Wise MB, Beaudry PH. Pulmonary function studies in idiopathic pulmonary hemosiderosis in children. Am Rev Respir Dis. 1973;107:410-415.
81. Ali A, Milman N, Clausen PP. Idiopathic pulmonary hemosiderosis: favorable effect of corticosteroids in two women aged 16 and 55 years. Eur Respir Topic. 1998;4:53-57.
82. Ewan PW, Jones HA, Rhodes CG, et al. Detection of intrapulmonary hemorrhage with carbon monoxide uptake: application in Goodpasture's syndrome. N Engl J Med. 1976;295:1391-1396.
83. Akyar S, Ozbek SS. Computed tomography findings in idiopathic pulmonary hemosiderosis. Respiration. 1993;60:63-64.
84. Buschman DL, Ballard R. Progressive massive fibrosis associated with idiopathic pulmonary hemosiderosis. Chest. 1993;104:293-295.
85. DeGowin RL, Sorensen LB, Charleston DB, et al. Retention of radioiron in the lungs of a woman with idiopathic pulmonary hemosiderosis. Ann Intern Med. 1968;69:1213-1220.
86. Dutau G, Ghisolfi J, Rochiccioli P, et al. [Idiopathic pulmonary hemosiderosis: apropos of a series of 7 cases: diagnostic value of isotope exploration]. Pediatrie. 1972;27:647-667.
87. Gilly R, Farouz S, Mamelle JC, et al. [Idiopathic pulmonary hemosiderosis in a child (benefits of iron 59 isotopic exploration and electronic microscopy)]. Lyon Med. 1972;227:1095-1104.
88. Kurzweil PR, Miller DR, Freeman JE, et al. Use of sodium chromate Cr51 in diagnosing childhood idiopathic pulmonary hemosiderosis. Am J Dis Child. 1984;138:746-748.
89. Miller T, Tanaka T. Nuclear scan of pulmonary hemorrhage in idiopathic pulmonary hemosiderosis. AJR Am J Roentgenol. 1979;132:120-121.
90. Samuels LD, Bass JC. 51Cr lung scan in idiopathic pulmonary hemosiderosis. J Nucl Med. 1969;10:106-107.
91. Brambilla CG, Brambilla EM, Stoebner P, et al. Idiopathic pulmonary hemorrhage: ultrastructural and mineralogic study. Chest. 1982;81:120-123.
92. Barlow AD. Pulmonary hemosiderosis. Proc R Soc Med. 1946;39:131-132.
93. Elinder G. Budesonide inhalation to treat idiopathic pulmonary haemosiderosis. Lancet. 1985;1:981-982.
94. Tutor JD, Eid NS. Treatment of idiopathic pulmonary hemosiderosis with inhaled flunisolide. South Med J. 1995;88:984-986.
95. Byrd RB, Gracey DR. Immunosuppressive treatment of idiopathic pulmonary hemosiderosis. JAMA. 1973;226:458-459.
96. Rossi GA, Balzano E, Battistini E, et al. Long-term prednisone and azathioprine treatment of a patient with idiopathic pulmonary hemosiderosis. Pediatr Pulmonol. 1992;13:176-180.
97. Airaghi L, Ciceri L, Giannini S, et al. Idiopathic pulmonary hemosiderosis in an adult: favourable response to azathioprine. Monaldi Arch Chest Dis. 2001;56:211-213.
98. Bagnato L, Grilli C, Portioli P, et al. [Long-term evaluation of immunosuppressive therapy in childhood idiopathic pulmonary hemosiderosis]. Pediatr Med Chir. 1986;8:671-674.
99. Berger G, Rupprecht E. [Contribution to the treatment of idiopathic pulmonary hemosiderosis by means of immunosuppressive agents]. Padiatr Grenzgeb. 1978;17:213-220.
100. Carnelli V, Biraghi V, Zurlo MG, et al. [Efficacy of treatment with cyclophosphamide in a case of idiopathic pulmonary hemosiderosis]. Minerva Pediatr. 1979;31:3893-3900.
101. Ceruti DE, Casar CC, Diaz CA, et al. [Idiopathic pulmonary hemosiderosis; long-term follow-up in 10 patients treated with corticoids and immunosuppressive agents]. Bol Med Hosp Infant Mex. 1980;37:985-1002.
102. Garatti M, Parravicini C, Meroni PL, et al. [Idiopathic pulmonary hemosiderosis: report of a case with a favorable response to cyclophophamide therapy]. Pediatr Med Chir. 1983;5:95-98.
103. Meral A, Gunay U, Kucukerdogan A, et al. Chloroquine in idiopathic pulmonary hemosiderosis: a case report. Turk J Pediatr. 1997;39:111-115.
104. O'Donohue WJ Jr. Idiopathic pulmonary hemosiderosis with manifestations of multiple connective tissue and immune disorders: treatment with cyclophosphamide. Am Rev Respir Dis. 1974;109:473-479.
105. Ohga S, Takahashi K, Miyazaki S, et al. Idiopathic pulmonary haemosiderosis in Japan: 39 possible cases from a survey questionnaire. Eur J Pediatr. 1995;154:994-995.
106. Ioachimescu O. [Idiopathic pulmonary hemosiderosis in adult]. Pneumologia. 2003;52:38-43.
107. Wroblewski BM, Stefanovic CR, McDonough VM, et al. The challenges of idiopathic pulmonary hemosiderosis and lung transplantation. Crit Care Nurse. 1997;17:39-44.
108. Calabrese F, Giacometti C, Rea F, et al. Recurrence of idiopathic pulmonary hemosiderosis in a young adult patient after bilateral single-lung transplantation. Transplantation. 2002;74:1643-1645.
109. Chryssanthopoulos C, Cassimos C, Panagiotidou C. Prognostic criteria in idiopathic pulmonary hemosiderosis in children. Eur J Pediatr. 1983;140:123-125.
110. Saeed MM, Woo MS, MacLaughlin EF, et al. Prognosis in pediatric idiopathic pulmonary hemosiderosis. Chest. 1999;116:721-725.
111. Miralles F, Torres J, Robles M. [Pregnancy in patients with idiopathic pulmonary hemosiderosis: presentation of a case]. Arch Bronconeumol. 1998;34:317-318.
112. Helman DL, Sullivan A, Kariya ST, et al. Management of idiopathic pulmonary haemosiderosis in pregnancy: report of two cases. Respirology. 2003;8:398-400.
113. Louie S, Russell LA, Richeson RB III, et al. Circulating immune complexes with pulmonary hemorrhage during pregnancy in idiopathic pulmonary hemosiderosis. Chest. 1993;104:1907-1909.
114. Michaeli J, Kornberg A, Menashe M, et al. Exacerbation of idiopathic pulmonary hemosiderosis in pregnancy. Eur J Obstet Gynecol Reprod Biol. 1987;25:153-158.
115. Gurevich V, Thomas MA. Idiopathic pulmonary hemorrhage in pregnancy: report of a case suggesting early pulmonary hemosiderosis with clinical recovery after steroid therapy. N Engl J Med. 1959;261:1154-1159.
116. Kiper N, Gocmen A, Ozcelik U, et al. Long-term clinical course of patients with idiopathic pulmonary hemosiderosis (1979-1994): prolonged survival with low-dose corticosteroid therapy. Pediatr Pulmonol. 1999;27:180-184.