Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-γ

Experimental and Molecular Medicine

Volumn 36, Issue 6, 2004, Pages 534-544

  Lee, Kyoung Jin ^a   Kim, Hyun A ^a   Kim, Pyeung Hyeun ^a   Lee, Hansoo ^a   Ma, Kyung Ran ^a   Park, Jeong Hyun ^a   Kim, Dae Joong ^a   Hahn, Jang Hee ^a  

^a Kangwon National University   (South Korea)

Author keywords

CD36; MMP 9; Monocyte; ox LDL; PMA; PPAR

Indexed keywords

CD36 ANTIGEN; CIGLITAZONE; GELATINASE B; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN F2 ALPHA; TROGLITAZONE;

ARTICLE; CELL CULTURE; CELL MIGRATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; DNA TRANSFECTION; ENZYME ACTIVITY; EXTRAVASATION; HUMAN; HUMAN CELL; MONOCYTE; PROTEIN EXPRESSION;

EID: 12344315733     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2004.68     Document Type: Article

References (24)

1. Ardans JA, Economou AP, Martinson JM Jr, Zhou M, Wahl LM. Oxidized low-density and high-density lipoproteins regulate the production of matrix metalloproteinase-1 and -9 by activated monocytes. J Leukoc Biol. 2002;71:1012-8
2. Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem. 2003;278:10443-9
3. Chung SW, Kang BY, Kim SH, Pak YK, Cho D, Trinchieri G, Kim TS. Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B. J Biol Chem 2000;275:32681-7
4. Collins AR, Meehan WP, Kintscher U, Jackson S, Wakino S, Noh G, Palinski W, Hsueh WA, Law RE. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 2001;21:365-71
5. Devaraj S, Hugou I, Jialal I. Alpha-tocopherol decreases CD 36 expression in human monocyte-derived macrophages. J Lipid Res 2001;42:521-7
6. Hah N, Lee ST. An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells. Biochem Biophys Res Commun 2003;305:428-33
7. Han CY, Park SY, Pak YK. Role of endocytosis in the transactivation of nuclear factor-kappaB by oxidized low-density lipoprotein. Biochem J 2000;350:829-37
8. Holven KB, Halvorsen B, Schulz H, Aukrust P, Ose L, Nenseter MS. Expression of matrix metalloproteinase-9 in mononuclear cells of hyperhomocysteinaemic subjects. Eur J Clin Invest 2003;33:555-60
9. Jang HI, Lee H. A decrease in the expression of CD63 tetraspanin protein elevates invasive potential of human melanoma cells. Exp Mol Med 2003;35:317-23
10. Jiang C, Ting AT, Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998; 39:82-6
11. Han J, Hajjar DP, Febbraio M, Nicholson AC. Native and modified low density lipoproteins increase the functional expression of the macrophage class B scavenger receptor, CD36. J Biol Chem 1997;272:21654-9
12. Kim YS, Han CY, Kim SW, Kim JH, Lee SK, Jung DJ, Park SY, Kang H, Choi HS, Lee JW, Pak YK. The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kappa b in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7. J Biol Chem 2001;276:33736-40
13. Logan SK, Garabedian MJ, Campbell CE, Webe Z. Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and its transcription factors. J Biol Chem 1996;271: 7774-82
14. Marx N, Sukhova G, Murphy C, Libby P, Plutzky J. Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma (PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro. Am J Pathol 1998;153:17-23
15. Marx N, Froehlich J, Siam L, Ittner J, Wierse G, Schmidt A, Scharnagl H, Hombach V, Koenig W. Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2003;23:283-8
16. Mikita T, Porter G, Lawn RM, Shiftman D. Oxidized low density lipoprotein exposure alters the transcriptional response of macrophages to inflammatory stimulus. J Biol Chem. 2001;276:45729-39
17. Mohtai M, Smith RL, Schurman DJ, Tsuji Y, Torti FM, Hutchinson NI, Stetler-Stevenson WG, Goldberg GI. Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin-1. J Clin Invest 1993;92: 179-85
18. Nagase H, Barrett AJ, Woessner JF. Nomaneclature and glossary of the matrix metalloproteinase. Matrix Suppl: 1992; 421-24
19. Nagy L, Tontonoz P, Alvarez, JGA, Chen H, and Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-γ. Cell 1998;93:229-40
20. Reginato MJ, Krakow SL, Bailey ST, Lazar MA. Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma. J Biol Chem 1998;23:273:1855-8
21. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998;391:79-82
22. Tontonoz P, Nagy L, Alvarez JGA, Thomazy VA, Evans R. PPAR-γ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998;93:241-52
23. Woo JH, Park JW, Lee SH, Kim YH, Lee IK, Gabrielson E, Lee SH, Lee HJ, Kho YH, Kwon TK. Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor kappa B transcriptional activity. Cancer Res 2003;63:3430-4
24. Xu XP, Meisel SR, Ong JM, Kaul S, Cercek B, Rajavashisth TB, Sharifi B, Shah PK. Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human monocyte-derived macrophages. Circulation 1999; 99:993-8