Stimulation of 5-HT1A receptor with 8-OH-DPAT inhibits hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells

Pharmacological Research

Volumn 51, Issue 3, 2005, Pages 261-268

  Lee, Hyun Joo ^a   Ban, Ju Yeon ^a   Cho, Soon Ock ^a   Seong, Yeon Hee ^a  

^a Chungbuk National University   (South Korea)

Author keywords

5 HT1A receptor; 8 OH DPAT; H2O2; Neuronal cell; Neurotoxicity

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; CALCIUM ION; CASPASE 3; DIZOCILPINE; DOPAMINE RECEPTOR BLOCKING AGENT; GLUTAMIC ACID; HOE 33342; HYDROGEN PEROXIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; REACTIVE OXYGEN METABOLITE; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SPIPERONE;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CELL CULTURE; CELL DEATH; CELL NUCLEUS; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOSOL; DRUG EFFECT; DRUG SCREENING; DRUG SELECTIVITY; DRUG SPECIFICITY; ENZYME ACTIVITY; FETUS; INHIBITION KINETICS; NEUROTOXICITY; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PRIORITY JOURNAL; RAT; STAINING; STIMULATION; ANIMAL; CELL SURVIVAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENTIATION; FEMALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROGEN PEROXIDE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A;

EID: 12344310986     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phrs.2004.09.003     Document Type: Article

References (44)

1. C.W. Olanow A radical hypothesis for neurodegeneration Trends Neurosci 16 1993 439 444
2. A.M. Gardner, F.H. Xu, C. Fady, F.J. Jacoby, D.C. Duffey, and Y. Tu Apoptotic versus nonapoptotic cytotoxicity induced by hydrogen peroxide Free Radic Biol Med 22 1996 73 83
3. A. Volterra, D. Trotti, and G. Racagni Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms Mol Pharmacol 46 1994 986 992
4. 2-induced neuronal apoptosis J Neurochem 73 1999 1181 1188
5. E.R. Whittemore, D.T. Loo, J.A. Watt, and C.W. Cotman A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture Neuroscience 67 1995 921 932
6. S. Duffy, and B.A. MacViar In vitro ischemia promotes calcium influx and intracellular calcium release in hippocampal astrocytes J Neurosci 16 1996 71 81
7. 2+ concentration can be useful tool to predict neuronal damage and neuroprotective properties of drugs Brain Res 732 1996 87 94
8. Q. Li, S. Clark, D.V. Lewis, and W.A. Wilson NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neutoxicity J Neurosci 22 2002 3070 3080
9. 1A receptors mediate opposing responses on membrane excitability in rat association cortex Neuroscience 40 1991 399 412
10. 2+ current inhibition produced by serotonin in rat dorsal raphe neurons J Neurosci 11 1991 3594 3609
11. 1A receptor agonist 8-OH-DPAT Eur J Pharmacol 358 1998 147 152
12. Prehn JHM, M. Welsch, C. Backhauβ, J. Nuglish, F. Ausmeier, and C. Karkoutly Effects of serotonergic drugs in experimental brain ischemia Brain Res 630 1993 10 20
13. G. Srkalovic, M. Selim, M.A. Rea, and J.D. Glass Serotonergic inhibition of extracellular glutamate in the suprachiasmatic nuclear region assessed using in vivo brain microdialysis Brain Res 656 1994 302 308
14. 2+- and glutamatergic receptor-evoked arachidonic acid and NO/cGMP release in adult hippocampus Neurochem Int 28 1996 439 444
15. 1A receptors inhibits apoptosis induced by serum deprivation in cultured neurons from chick embryo Brain Res 777 1997 179 186
16. 1A receptor agonist 8-hydroxy-2-(di-n- propylamino)tetralin against traumatic brain injury-induced cognitive deficits and neuropathology in adult male rats Neurosci Lett 333 2002 179 182
17. M.V. Berridge, and A.S. Tan Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction Arch Biochem Biophys 303 1993 474 482
18. D.W. Ellison, M.F. Beal, and J.B. Martin Amino acid neurotransmitters in postmortem human brain analyzed by high performance liquid chromatography with electro-chemical detection J Neurosi 19 1987 305 315
19. V.H. Sethy, B.R. Ellerbrock, G.J. Fici, and H. Wu D2 and D1 dopaminergic activity 7-OH-DPAT Brain Res 733 1996 41 45
20. B. Halliwell Reactive oxygen species and the central nervous system J Neurochem 59 1992 1609 1623
21. H. Wang, and J.A. Joseph Mechanisms of hydrogen peroxide-induced calcium dysregulation in PC12 cells J Neurosci 28 2000 1222 1231
22. 2-evoked, intracellular calcium increases in the rat N18-RE-105 neuronal cell line by pretreatment with an electrophilic antioxidant inducer Neurosci Lett 273 1999 109 112
23. S.B. Koh, J.Y. Ban, B.Y. Lee, and Y.H. Seong Protective effects of fangchinoline and tetrandrine on hydrogen peroxide-induced oxidative neuronal cell damage in cultured rat cerebellar granule cells Planta Med 69 2003 506 512
24. D.W. Nicholson, and N.A. Thornberry Caspases: killer proteases Trends Biochem Sci 22 1997 299 306
25. G.S. Salvesen, and V.M. Dixit Caspases: intracellular signaling by proteolysis Cell 91 1997 443 446
26. R.U. Jänicke, M.L. Sprengart, M.R. Wati, and A.G. Porter Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis J Biol Chem 273 1998 9357 9360
27. M. Woo, R. Hakem, M.S. Soengas, G.S. Duncan, A. Shahinian, and D. Kagi Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes Genes Dev 12 1998 806 819
28. 2 neurotoxicity Neurosci Lett 305 2001 61 64
29. A. Pazos, and J.M. Palacios Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors Brain Res 346 1985 205 230
30. Y. Chaput, R.C. Araneda, and R. Andrade Pharmacological and functional analysis of a novel serotonin receptor in the rat hippocampus Eur J Pharmacol 182 1990 441 456
31. K. Rupalla, R. Jakob, and J. Krieglstein Effects of 5-HT1A receptor agonists on the glutamate-induced rise in cytosolic calcium concentration as well as on calcium and potassium currents in hippocampal neurons J. Krieglstein H. Oberpichler-Schwenk Pharmacology of cerebral ischemia 1994 Medpharm Scientific Publishers Stuttgart 89 94
32. K. Murase, M. Randie, T. Shirasaki, T. Nakagawa, and N. Akaike Serotonin suppresses N-methyl-d-aspartate responses in acutely isolated spinal dorsal horn of the rat Brain Res 525 1990 84 91
33. + currents in rat serotonergic neurons J Physiol 496 1996 120 137
34. 1A receptor activation protects against N-methyl-d-aspartate-induced apoptotic cell death in striatal and mesencephalic cultures J Pharmacol Exp Ther 304 2003 913 923
35. 1A receptor agonist 8-OH-DPAT: possible significance for neuroprotection Eur J Pharmacol 406 2000 319 324
36. 2 receptors Eur J Pharmacol 145 1988 31 38
37. 2+ homeostasis Neurosci Res 37 2000 227 236
38. K. Takuma, K. Mori, E. Lee, R. Enomoto, A. Baba, and T. Matsuda Heat shock inhibits hydrogen peroxide-induced apoptosis in cultured astrocytes Brain Res 946 2002 232 238
39. F. Huang, M.C. Vemuri, and J.S. Schneider Modulation of ATP levels alters the mode of hydrogen peroxide-induced cell death in primary cortical cultures: effects of putative neuroprotective agents Brain Res 997 2004 79 88
40. 2 receptor antagonists Eur J Pharmacol 229 1992 21 29
41. 1A receptor activation on spreading depression in rat neocortical slices Neuroreport 10 1999 2641 2646
42. Nuglisch J, Karkoutly C, Peruche B, Prehn JHM, Welsch M, Mennel HD, et al. Effect of the 5-HT1A agonist CM57493 on infarct area, infarct volume and hippocampal neuronal damage after focal and global cerebral ischemia in mice and rats. In: Krieglstein J, Oberpichler H, editors. Pharmacology of Cerebral Ischemia. Stuttgart: Wissenschaftliche Verlagsgesellschaft, 1990. p. 493-497.
43. 1A receptor agonists, 8-OH-DPAT, buspirone and flesinoxan, upon brain damage induced by transient global cerebral ischemia in gerbils Arch Int Pharmacodyn Ther 329 1995 347 359
44. 1A agonist improves motor complications in rodent and primate Parkinson models Neurology 57 2001 1829 1834