Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease

Molecular Brain Research

Volumn 133, Issue 1, 2005, Pages 1-5

  Miguel, Rosa Ferrando ^a   Pollak, Arnold ^a   Lubec, Gert ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

ADAMTS; Alzheimer's disease; Down syndrome; Metalloproteinase; Neurodegeneration; Pick's disease

Indexed keywords

DISINTEGRIN; ENZYME ANTIBODY; METALLOPROTEINASE; METALLOPROTEINASE ADAMTS 1; METALLOPROTEINASE ADAMTS 5; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN SYNDROME; FRONTAL CORTEX; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOREACTIVITY; PICK PRESENILE DEMENTIA; PRIORITY JOURNAL;

ADAM PROTEINS; AGED; ALZHEIMER DISEASE; BLOTTING, WESTERN; DISINTEGRINS; DOWN SYNDROME; FRONTAL LOBE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; METALLOENDOPEPTIDASES; MIDDLE AGED; PICK DISEASE OF THE BRAIN; POSTMORTEM CHANGES;

EID: 12344296461     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.09.008     Document Type: Article

References (26)

1. S.S. Apte A disintegrin-like and metalloproteinase (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family Int. J. Biochem. Cell Biol. 36 2004 981 985
2. G.M. Castillo, W. Lukito, T.N. Wight, and A.D. Snow The sulfate moieties of glycosaminoglycans are critical for the enhancement of beta-amyloid protein fibril formation J. Neurochem. 72 1999 1681 1687
3. M.S. Cheon, S.H. Kim, M.L. Yaspo, F. Blasi, Y. Aoki, K. Melen, and G. Lubec Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain: challenging the gene dosage effect hypothesis (Part I) Amino Acids 24 2003 111 117
4. D.A. De Witt, J. Silver, D.R. Canning, and G. Perry Chondroitin sulfate proteoglycans are associated with the lesions of Alzheimer's disease Exp. Neurol. 121 1993 149 152
5. J. Díaz-Nido, F. Wandosell, and J. Avila Glycosaminoglycans and β-amyloid, prion and tau peptides in neurodegenerative diseases Peptides 23 2002 1323 1332
6. R. Ferrando-Miguel, M.S. Cheon and G. Lubec, Aberrant chromosome 21 gene products: explaining the Down Syndrome phenotype? Neuroembryol., Editorial, in press.
7. R.A. Floyd Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development Free Radic. Biol. Med. 26 1999 1346 1355
8. L.M. Grimaldi, V.M. Casadei, C. Ferri, F. Veglia, F. Licastro, G. Annoni, I. Biunno, G. De Bellis, S. Sorbi, C. Mariani, N. Canal, W.S. Griffin, and M. Franceschi Association of early-onset Alzheimer's disease with an interleukin-1 alpha gene polymorphism Ann. Neurol. 47 2000 361 365
9. T.L. Hurskainen, S. Hirohata, M.F. Seldin, and S.S. Apte ADAM-TS5, ADAM-TS6 and ADAM-TS7, novel members of a family of zinc metalloproteinases J. Biol. Chem. 274 1999 25555 25563
10. K. Krapfenbauer, E. Engidawork, N. Cairns, M. Fountoulakis, and G. Lubec Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders Brain Res. 967 2003 152 160
11. K. Kuno, N. Kanada, E. Nakashima, F. Fujiki, F. Ichimura, and K. Matsushima Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene J. Biol. Chem. 272 1997 556 562
12. K. Kuno, Y. Okada, H. Kawashima, H. Nakamura, M. Miyasaka, H. Ohno, and K. Matsushima ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan FEBS Lett. 478 2000 241 245
13. G. Lubec, O. Labudova, N. Cairns, and M. Fountoulakis Increased glyceraldehyde 3-phosphate dehydrogenase levels in the brain of patients with Down's syndrome Neurosci. Lett. 260 1999 141 145
14. 165 J. Biol. Chem. 278 2003 23656 23665
15. D. Pollak, N. Cains, and G. Lubec Cytoskeleton derangement in brain of patients with Down syndrome, Alzheimer's disease and Pick's disease J. Neural Transm., Suppl. 67 2003 149 158
16. J.C. Rodríguez-Manzaneque, A.B. Milchanowski, E.K. Dufour, R. Leduc, and M.L. Iruela-Arispe Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms J. Biol. Chem. 275 2000 33471 33479
17. J.C. Rodríguez-Manzaneque, J. Westling, S.N.M. Thai, A. Luque, V. Knauper, G. Murphy, J.D. Sandy, and M.L. Iruela-Arispe ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors Biochem. Biophys. Res. Commun. 293 2002 501 508
18. 442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4 J. Biol. Chem. 276 2001 13372 13378
19. M. Sasaki, S. Seo-Kiryu, R. Kato, S. Kita, and H. Kiyama A disintegrin and metalloproteinase with thrombospondin type 1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons Mol. Brain Res. 89 2001 158 163
20. T. Shindo, H. Kurihara, K. Kuno, H. Yokoyama, T. Wada, Y. Kurihara, T. Imai, Y. Wang, M. Ogata, H. Nishimarsu, N. Moriyama, Y. Oh-hashi, H. Morita, T. Ishikawa, R. Nagai, Y. Yazaki, and K. Matsushima ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function J. Clin. Invest. 105 2000 1345 1352
21. A.D. Snow, H. Mar, D. Nochlin, K. Kimta, M. Kato, S. Suzuki, J. Hassell, and T.N. Wight The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease Am. J. Pathol. 133 1988 456 463
22. S.N.M. Thai, and M.L. Iruela-Arispe Expression of ADAMTS1 during murine development Mech. Dev. 115 2002 181 185
23. M.D. Tortorella, R.Q. Liu, T. Burn, R.C. Newton, and E. Amer Characterization of human aggrecanase-2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4) Matrix Biol. 21 2002 499 511
24. F. Vázquez, G. Hastings, M.A. Ortega, T.F. Lane, S. Oikemus, M. Lombardo, and M.L. Iruela-Arispe METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity J. Biol. Chem. 274 1999 23349 23357
25. P. Wei, Y. Zhao, L. Zhuang, D.R. Hurst, S. Ruben, and Q.A. Sang Protein engineering and properties of human metalloproteinase and thrombospondin 1 Biochem. Biophys. Res. Commun. 293 2002 478 488
26. W. Yuan, R.T. Matthews, J.D. Sandy, and P.E. Gottschall Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats Neuroscience 114 2002 1091 1101