Radical ideas: Genetic responses to oxidative stress

Clinical and Experimental Pharmacology and Physiology

Volumn 26, Issue 1, 1999, Pages 64-68

  Demple, Bruce ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Free radicals; Haem oxygenase; Nitric oxide; OxyR; Post transcriptional control; SoxR; Transcriptional control

Indexed keywords

CATALASE; FUMARATE HYDRATASE; HEME OXYGENASE; NITRIC OXIDE; PARAQUAT; PEROXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR;

ADAPTATION; AEROBIC METABOLISM; ANTIBIOTIC RESISTANCE; CONFERENCE PAPER; DISULFIDE BOND; GENE INDUCTION; HOMEOSTASIS; MOTONEURON; OXIDATION; OXIDATIVE STRESS; TRANSCRIPTION REGULATION;

ANIMALS; FREE RADICALS; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MICE; OXIDATIVE STRESS;

EID: 0032950481     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.1999.02993.x     Document Type: Conference Paper

References (41)

1. 1. Sies H (ed.). Oxidative Stress: Oxidants and Antioxidants. Academic Press, London. 1991.
2. 2. von Sonntag C. The Chemical Basis of Radiation Biology. Taylor and Francis, London. 1987.
3. 3. Babior BM. The respiratory burst oxidase. Enzymol. Rel. Areas Mol. Biol. 1992; 65: 49-65.
4. 4. Marletta MA. Nitric oxide synthase: Function and mechanism. Adv. Exp. Med. Biol. 1993; 338: 281-4.
5. 5. Greenberg JT, Demple B. A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress. J. Bacteriol. 1989; 171: 3933-9.
6. 6. Hidalgo E, Demple B. Adaptive responses to oxidative stress: The soxRS and oxyR regutions. In: Lin ECC, Lynch AS (eds). Regulation of Gene Expression in Escherichia coli. RG Landes, Austin, TX. 1996; 435-52.
7. 7. Storz G, Tartaglia LA, Ames BN. Transcriptional regulator of oxidative stress-inducible genes: Direct activation by oxidation. Science 1990; 248: 189-94.
8. 8. Toledano MB, Kullik I, Trinh F, Baird PT, Schneider TD, Storz G. Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: A mechanism for differential promoter selection. Cell 1994; 78: 897-909.
9. 9. Kullik I, Toledano MB, Tartaglia LA, Storz. G. Mututional analysis of the redox-sensitive transcriptional regulator OxyR: Regions important for oxidation and transcriptional activation. J. Bacteriol. 1995; 177: 1275-84.
10. 10. Zheng M, Åslund F, Storz G. Activation of the OxyR transcription factor by reversible disulfide bond formation. Science 1998; 279: 1718-21.
11. 11. Storz G, Christman MF, Sies H, Ames BN. Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium. Proc. Natl Acad. Sci. USA 1987, 84: 8917-21.
12. 12. Greenberg JT, Demple B. Overproduction of peroxide-scavenging enzymes in Escherichia coli suppresses spontaneous mutagenesis and sensitivity to redox-cycling agents in oxyR-mutants. EMBO J. 1988; 7: 2611-17.
13. 13. Gonzalez-Flecha B, Demple B. Metabolic sources of hydrogen peroxide in aerobically growing Escherichia coli. J. Biol. Chem. 1995; 270: 13681-7.
14. 14. Gonzalez-Flecha B, Demple B. Homeostatic regulation of the intracellular concentration of hydrogen peroxide in aerobically growing Escherichia coli. J. Bacteriol. 1997; 179: 382-8.
15. 15. González-Flecha B, Demple B. Transcriptional regulation of the Escherichia coli oxyR gene as a function of cell growth. J. Bacteriol. 1997; 179: 6181-6.
16. 16. Tsaneva IR, Weiss B. soxR, a locus governing a superoxide response regulon in Escherichia coli K-12. J. Bacteriol. 1990; 172: 4197-205.
17. 17. Wu J, Weiss B. Two divergently transcribed genes, soxR and soxS, control a superoxide response regulon of Escherichia coli. J. Bacteriol. 1991; 173: 2864-71.
18. 18. Amábile-Cuevas CF, Demple B. Molecular characterization of the soxRS genes of Escherichia coli: Two genes control a superoxide stress regulon. Nucleic Acids Res. 1991; 19: 4479-84.
19. 19. White DG, Goldman JD, Demple B, Levy SB. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli. J. Bacteriol. 1997; 179: 6122-6.
20. 20. Li Z, Demple B. SoxS, an activator of superoxide stress genes in Escherichia coli. Purification and interaction with DNA. J. Biol. Chem. 1994; 269: 18371-7.
21. 21. Hidalgo E, Demple B. An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein. EMBO J. 1994; 13: 138-16.
22. 22. Hidalgo E, Bollinger Jr JM, Bradley TM, Walsh CT, Demple B. Binucleur [2Fe-2S] clusters in the Escherichia coli SoxR protein and role of the metal centers in transcription. J. Biol. Chem. 1995; 270: 20 908-14.
23. 23. Wu J, Dunham WR, Weiss B. Overproduction and physical characterization of SoxR. a [2Fe-2S] protein that governs an oxidative response regulon in Escherichia coli. J. Biol. Chem. 1995; 270: 10121-7.
24. 24. Ding H, Hidalgo E, Demple B. The Redox state of the [2Fe-2S] clusters in SoxR protein regulates its activity as a transcription factor. J Biol. Chem. 1996; 271: 33 173-5.
25. 25. Gaudu P, Weiss B. SoxR, a [2Fe-2S] transcription factor, is active only in its oxidized form. Proc. Natl Acad. Sci. USA 1996; 93: 10094-8.
26. 26. Hidalgo E, Ding H, Demple B. Redox signal transduction: mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form. Cell 1997; 88: 121-9.
27. 27. Gaudu P, Moon N, Weiss B. Regulation of the soxRS oxidative stress regulon. Reversible oxidation of the Fe-S centers of SoxR in viro. J. Biol Chem. 1997; 272: 5082-6.
28. 28. Nunoshiba T, Demple B. A cluster of constitutive mutations affecting the C-terminus of the redox-sensitive SoxR transcriptional activator. Nucleic Acids Res. 1994; 22: 2958-62.
29. 29. Ding H, Demple B. In vivo kinetics of a redox-regulated transcriptional switch. Proc. Nait Acad. Sci. USA 1997; 94: 8445-9.
30. 30. Nunoshiha T, deRojas-Walker T, Wishnok JS, Tannenbaum SR, Demple B. Activation hy nitric oxide of an oxidative-stress response that defends Escherichia coli against activated macrophages, Proc. Nutl Acad. Sci. USA 1993; 90: 9993-7.
31. 31. Nunoshiha T, deRojas-Walker T, Tannenbaum SR, Demple B. Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophages. Infect. Immun. 1995; 63: 794-8.
32. 32. Fang FC, Vazqueztorres A, Xu YS. The transcriptional regulator SoxS is required for resistance of Salmonella typhimurium to paraquat but not for virulence in mice. Infect. Immun. 1997; 65: 5371-5.
33. 33. Hobbs AJ, Ignarro LJ. Nitric oxide - cyclic GMP signal transduction system. Methods Enzymol. 1996; 269: 134-48.
34. 34. Tamir S, Lewis RS, deRojas-Walker T, Deen WM, Wishnok JS, Tannenbaum SR. The influence of delivery rate on the chemistry and biological effects of nitric oxide. Chem. Res. Toxicol 1993; 6: 895-9.
35. 35. Marquis JC, Demple B. Complex genetic response of human cells to sublethal levels of pure nitric oxide. Cancer Res. 1998; 58: 3435-40.
36. 36. Kim Y-M, Bergonia H, Lancaster JRJ. Nitrogen oxide-induced autoprotection in isolated rat hepatocytes. FEBS Lett. 1995; 374: 228-32.
37. 37. Hartsfield CL, Alam J, Cook JL, Choi AM. Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide. Am. J. Physiol 1997; 273: L980-8.
38. 38. Drapier J-C. Interplay between NO and [Fe-S] clusters: Relevance to biological systems. Methods 1997; 11: 319-29.
39. 39. Durham HD, Dahrouge S, Cashman NR. Evaluation of the spinal cord neuron X neuroblastoma hybrid cell line NSC-34 as a model for neurotoxicity testing. Neurotoxicology 1993, 14: 387-95.
40. 40. Hidalgo E, Ding H, Demple B. Redox signal transduction via ironsulfur clusters in the SoxR transcription activator. Trends Biochem. Sci. 1997; 22: 207-10.
41. 41. Bishop A, Marquis JC, Cashman NR, Demple B. Adaptive resistance to nitric oxide in motor neurons. Free Rad. Biol Med. 1999 (in press).