Hepcidin and cytokines in anaemia

Hematology

Volumn 9, Issue 5-6, 2004, Pages 357-362

  Means Jr , Robert T ^a,b  

^a LEXINGTON VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Anaemia of chronic disease; Cytokines; Ferritin; Hepcidin; Inflammation; Iron

Indexed keywords

CYTOKINE; FERRITIN; GAMMA INTERFERON; HEPCIDIN; INTERLEUKIN 1; INTERLEUKIN 6; MESSENGER RNA; REGULATOR PROTEIN; TUMOR NECROSIS FACTOR;

ANEMIA; DISEASE ASSOCIATION; ERYTHROCYTE LIFESPAN; FERRITIN BLOOD LEVEL; HEMOCHROMATOSIS; HUMAN; INFLAMMATION; INTESTINE MUCOSA; IRON BALANCE; IRON DEFICIENCY ANEMIA; IRON METABOLISM; IRON STORAGE; LIVER ADENOMA; MICROCYTIC ANEMIA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; RETICULOENDOTHELIAL SYSTEM; REVIEW;

ADENOMA; ANEMIA; ANTIMICROBIAL CATIONIC PEPTIDES; CYTOKINES; ERYTHROCYTES; ERYTHROPOIESIS; HUMANS; IRON; LIVER NEOPLASMS;

EID: 12344263610     PISSN: 10245332     EISSN: None     Source Type: Journal    
DOI: 10.1080/10245330400018540     Document Type: Review

References (49)

1. Goodnough, L.T., Dubois, R.W. and Nissenson, A.R. (2003) "Anemia: not just an innocent bystander?", Arch. Inter. Med. 163, 1400-1404.
2. Lee, G.R. (1983) "The anemia of chronic disease", Seminars in Hematol. 20, 61-80.
3. Cash, J.M. and Sears, D.A. (1990) "The spectrum of diseases associated with the anemia of chronic disease: A study of 90 cases", Am. J. Med. 87, 638-644.
4. Means, R.T. (2003) "Recent developments in the anemia of chronic disease", Curr. Hematol. Rep. 2, 116-121.
5. Rodriguez, R.M., Corwin, H.L., Gettinger, A., Corwin, M.J., Gubler, D. and Pearl, R.G. (2001) "Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness", J. Crit. Care 16, 36-41.
6. Van Iperen, C.E., Kraaijenhagen, R.J., Biesma, D.H., Beguin, Y., Marx, J.J. and Van de Wiel, A. (1998) "Iron metabolism and erythropoiesis after surgery", Br. J. Surg. 85, 41-45.
7. Vincent, J.L., Baron, J-F, Reinhart, K., et al. (2002) "Anemia and blood transfusion in critically ill patients", J. Am. Med. Assoc. 288, 1499-1507.
8. Cartwright, G.E. (1966) "The anemia of chronic disease", Semin. Hematol. 3, 351-375.
9. Baer, A.N., Dessypris, E.N. and Krantz, S.B. (1990) "The pathogenesis of anemia in rheumatoid arthritis. A clinical and laboratory analysis", Semin. Arthritis Rheum. 14, 209-223.
10. Hochberg, M.C., Arnold, C.M., Hogans, B.B. and Spivak, J.L. "Serum immunoreactive erythropoietin in rheumatoid arthritis: impaired response to anemia", Arthritis Rheum. 31, 1318-1321.
11. Roodman, G.D., Horadam, V.W. and Wright, T.L. (1988) "Inhibition of erythroid colony formation by autologous bone marrow adherent cells in patients with the anemia of chronic disease", Blood (1983);62, 406-412.
12. Means, R.T. and Krantz, S.B. (1993) "Inhibition of human erythroid colony-forming units by tumor necrosis factor requires beta interferon", J. Clin. Investig. 91, 416-419.
13. Means, R.T., Dessypris, E.N. and Krantz, S.B. (1992) "Inhibition of human erythroid colony-forming units by interleukin-1 is mediated by gamma interferon", J. Cell. Physiol. 150, 59-64.
14. Jefferey, M.R. (1953) "Some observations on anemia in rheumatoid arthritis", Blood 8, 502-518.
15. Means, R.T. and Krantz, S.B. (1992) "Progress in understanding the pathogenesis of the anemia of chronic disease", Blood 80, 1639-1647.
16. Means, R.T. (1995) "Pathogenesis of the anemia of chronic disease: a cytokine-mediated anemia", Stem Cells 13, 32-37.
17. Means, R.T. (1999) "Advances in the anemia of chronic disease", Int. J. Hematol. 70, 7-12.
18. Means, R.T., Allen, J., Sears, D.A. and Schuster, S.J. (1999) "Serum soluble transferrin receptor and the prediction of marrow aspirate results in a heterogeneous group of patients", Clin. Lab. Haematol. 21, 161-167.
19. Denz, H., Fuchs, D., Huber, H., et al. (1990) "Correlation between neopterin, interferon-gamma, and haemoglobin in patients with haematological disorders", Eur. J. Haematol. 44 186-189.
20. Moldawer, L.L., Marano, M.A., Wei, H., et al. (1989) "Cachectin/tumor necrosis factor alters red blood cell kinetics and induces anemia in vivo", FASEB J. 3, 1637-1643.
21. Alvarez-Hernandez, X., Liceaga, J., McKay, I.C. and Brock, J.H. (1989) "Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor", Lab. Investig. 61, 319-322.
22. Rogers, J., Lacroix, L., Durmowitz, G., Kasschau, K., Andriotakis, J. and Bridges, K.R. (1994) "The role of cytokines in the regulation of ferritin expression", Adv. Exp. Med. Biol. 356 127-132.
23. Recalcati, S., Taramelli, D., Conte, D. and Cairo, G. (1998) "Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines: role of selective iron regulatory protein-2 downregulation", Blood 91, 1059-1066.
24. Bertero, M.T. and Caligaris-Cappio, F. (1997) "Anemia of chronic disorders in systemic autoimmune diseases", Haematologica 82, 375-381.
25. Domachowske, J.B. (1997) "The role of nitric oxide in the regulation of cellular iron metabolism", Biochem. Mol. Med. 60 1-7.
26. Weiss, G., Bogdan, C. and Hentze, M.W. (1997) "Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13", J. Immunol. 158, 420-425.
27. Oria, R., Sanchez, L., Houston, T., Hentze, M.W., Liew, F.Y. and Brock, J.H. (1995) "Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells", Blood 85, 2962-2966.
28. Watts, R.N. and Richardson, D.R. (2000) "Examination of the mechanism of action of nitrogen monoxide on iron uptake from transferrin", J. Lab. Clin. Med. 136, 149-156.
29. Peetre, C., Gullberg, U., Nilsson, E. and Olsson, I. (1986) "Effects of recombinant tumor necrosis factor on proliferation and differentiation of leukemic and normal hemopoietic cells in vitro. Relation to cell surface receptors", J. Clin. Investig. 78, 1694-1700.
30. Krause, A., Neitz, S., Mägert, H-J, Schulz, A., Forssmann, W-G, Schulz-Knappe, P., Aderman, K. (2000) "LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity", FEBS Lett. 480, 147-150.
31. Park, C.H., Valore, E.V., Waring, A.J. and Ganz, T. (2001) "Hepcidin, a urinary antimicrobial peptide synthesized in the liver", J. Biol. Chem. 276, 7806-7810.
32. Ganz, T. (2003) "Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation", Blood 102 783-788.
33. Pigeon, C., Ilyin, G., Courseland, B., Leroyer, P., Turlin, B., Brissot, P. and Loreal, O. (2001) "A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload", J. Biol. Chem. 276, 7811-7819.
34. Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A. and Vaulont, S. (2001) "Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice", Proc. Nat. Acad. Sci. U.S.A. 98, 8780-8785.
35. Fleming, R.E. and Sly, W.S. (2001) "Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease", Proc. Nat. Acad. Sci. U.S.A. 98, 8160-8162.
36. Roetto, A., Papanikolaou, G., Politou, M., et al. (2003) "Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis", Nat. Genet. 33, 21-22.
37. Gehrke, S.G., Kulakisz, H., Herrmann, T., Riedel, H-D, Bents, K., Veltkamp, C. and Stremmel, W. (2003) "Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin bound iron", Blood 102, 371-376.
38. Nemeth, E., Valore, E.V., Territo, M., Schiller, G., Lichtenstein, A. and Ganz, T. (2003) "Hepcidin, a putative mediator of anemia of inflammation, is a type II acute phase protein", Blood 101, 2461-2463.
39. Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B.K. and Ganz, T. (2004) "IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin", J. Clin. Investig. 113, 1271-1276.
40. Dallalio, G., Fleury, T. and Means, R.T. (2003) "Serum hepcidin in clinical specimens", Br. J. Haematol. 122, 996-1000.
41. Nicolas, G., Chauvet, C., Viatte, L., et al. (2002) "The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation", J. Clin. Investig. 110, 1037-1044.
42. Dallalio, G., Fleury, T. and Means, R.T. (2003) "Serum hepcidin and cytokines in anemic patients (abstract)", Blood 102(Suppl. 1):757a.
43. Nicolas, G., Viatte, L., Bennoun, M., Beaumont, C., Kahn, A. and Vaulmont, S. (2002) "Hepcidin, a new iron regulatory peptide", Blood Cells Mol. Dis. 29, 327-335.
44. Weinstein, D.A., Roy, C.N., Fleming, M.D., Loda, M.F., Wolsdorf, J.I. and Andrews, N.C. (2002) "Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease", Blood 100, 3776-3781.
45. Kulaksiz, H., Gehrke, S.G., Janetzko, A., Rost, D., Bruckner, T., Kallinowski, B. and Stemmel, W. (2004) "Pro-hepcidin: expression and cell specific localization in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia", Gut 53, 735-743.
46. Hunter, H.N., Fulton, D.B., Ganz, T. and Vogel, H.J. (2002) "The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis", J. Biol. Chem. 277, 37597-37603.
47. Tilg, H., Ulmer, H., Kaser, A. and Weiss, G. (2002) "Role of IL-10 for induction of anemia during inflammation", J. Immunol. 169, 2204-2209.
48. Beutler, E. (2003) "Unlocking the mysteries of iron homeostasis and of the anemia of chronic disease: is hepcidin the key?", Blood 102, 775.
49. Andrews, N.C. (2004) "Anemia of inflammation: the cytokine-hepcidin link", J. Clin. Investig. 113, 1251-1253.