Application of pH-responsive polymers to oral dosage forms for insulin

Drug Delivery System

Volumn 15, Issue 6, 2000, Pages 499-506

  Morishita, Mariko ^a   Nagai, Tsuneji ^a   Takayama, Kozo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

absorption enhancing effect; diabetes; insulin; oral delivery; pH responsive polymers

Indexed keywords

EID: 12244281596     PISSN: 09135006     EISSN: 18812732     Source Type: Journal    
DOI: 10.2745/dds.15.499     Document Type: Article

References (14)

1. Anonymous : Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetescare 20 : 1183-1197, 1997.
2. Hoffman A, Ziv E : Pharmacokinetic considerations of new insulin formulations and routes of administration. Clin pharmacokinet 33 : 285-301, 1997.
3. Morishita M, Morishita I, Takayama K, Machida Y, Nagai T : Sitedependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin. Biol Pharm Bull 16 : 68-72, 1993.
4. Morishita I, Morishita M, Takayama K, Machida Y, Nagai T : Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats. Int J Pharm 78 : 9-16, 1992.
5. Barichello JM, Morishita M, Takayama K, Chiba Y, Tokiwa S, Nagai T : Enhanced rectal absorption of insulin-loaded pluronic F-127 gels containing unsaturated fatty acids. Int J Pharm 183 : 125-132, 1999.
6. Morishita M, Kajita M, Suzuki A, Takayama K, Chiba Y, Tokiwa S, Nagai T : The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified eicosapentaenoic acid and docosahexaenoic acid. Int J Pharm 201 : 175-185, 2000.
7. Lowman AM, Peppas NA : Analysis of the complexation/decomplexation phenomena in polyelectrolyte networks. Macromolecules 30 : 4959-4965, 1997.
8. Peppas NA, Bures P, Leobandung W, Ichikawa H : Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 50 : 27-46, 2000.
9. Madsen F, Peppas NA : Complexation graft copolymer networks : swelling properties, calcium binding and proteolytic enzyme inhibition. Biomaterials 20 : 1701-1708, 1999.
10. Lowman AM, Peppas NA, Morishita M, Nagai T : Novel bioadhesive complexation networks for oral protein delivery(eds Macullough I, Shalaby S), Tailored Polymeric Materials for Controlled Delivery Systems, ACS Symposium Series, Vol. 709, ACS, Washington, DC, 1998, p 156-164.
11. Lowman AM, Morishita M, Kajita M, Nagai T, Peppas NA : Oral delivery of insulin using pH-responsive complexation gels. J Pharm Sci 88 : 933-937, 1999.
12. Lueßen HL, de Leeuw BJ, Perard D, Lehr C-M, de Boer AG, Verhoef JC, Junginger HE : Mucoadhesive excipients in peroral peptide drug delivery. I. Influence of mucoadhesive excipients on the proteolytic activity of intestinal enzymes. Eur J Pharm Sci 4 : 117-128, 1996.
13. Lueßen HL, Rentel C-O, Kotze AF, Lehr C-M, de Boer AG, Verhoef JC, Junginger HE : Mucoadhesive polymers in peroral prptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro. J Controlled Rel 45 : 15-23, 1997.
14. Peppas NA, Ichikawa H, Torres-Lugo M : Citotoxicity and transport enhancement of proteins through cell monolayers using novel pH-sensitive hydrogels. Proceedings of the 3rd World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 2000, p 201-202.