Concentrations of sphingosine and sphinganine in plasma of patients with type 2 diabetes

Medical Science Monitor

Volumn 11, Issue 1, 2005, Pages

  Górska, Maria ^a   Dobrzyń, Agnieszka ^a   Baranowski, Marcin ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Plasma; Sphinganine; Sphingosine; Type 2 diabetes

Indexed keywords

SPHINGANINE; SPHINGOSINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPOGENESIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; SECOND MESSENGER; SIGNAL TRANSDUCTION;

AGED; BLOOD GLUCOSE; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; HUMANS; MALE; MIDDLE AGED; SPHINGOSINE;

EID: 12244279034     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Huwiler A, Kotler T, Pfeilschifter J, Sandhoff K: Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim Biophys Acta, 2000; 1485: 63-99
2. Merrill AH Jr, Schmelz E-M, Dillehay DL et al: Sphingolipids - the enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicol Appl Pharmacol, 1997; 142: 208-25
3. Riboni L, Yiani P, Bassi R et al: The role of sphingolipids in the process of signal transduction. Prog Lipid Res, 1997; 36: 153-95
4. Shephard GS, Van der Westhuizen L: Liquid chromatographic determination of the sphinganine/sphingosine ratio in serum. J Chromatogr B, 1998; 710: 219-22
5. Ribar S, Mesaric M, Bauman M: High-performance liquid chromatographic determination of sphinganine and sphingosine in serum and urine of subjects from endemic nephropathy area in Croatia. J Chromatogr B, 2001; 754: 511-19
6. Mathur S, Constable PD, Eppley RM et al: Fumonisin BI increases serum sphinganine concentration but does not alter serum sphingosine concentration or induce cardiovascular changes in milk-fed calves. Toxicol Sci, 2001; 60: 379-84
7. Turinsky J, O'Sullivan DM, Bayly BP: 1,2-Diacylglycerol and ceramide levels in insulin resistant tissues of the rats in vivo. J Biol Chem, 1990; 262: 16880-85
8. Górska M, Dobrzyń A, Żendzian-Piotrowska M, Górski J: Effect of streptozotocin diabetes on functioning of the sphingomyelin signaling pathway in rat skeletal muscles. Endokrynol Pol, 2002; 53(Suppl.1): 295-96
9. Mathur S, Constable PD, Eppley RM et al: Fumonisin BI is hepatotoxic and nephrotoxic in milk-fed calves. Toxicol Sci, 2001; 60: 385-96
10. Sabbadini RA, McNutt W, Jenkins G et al: Sphingosine is endogenous to cardiac and skeletal muscle. Biochem Biophys Res Commun, 1993; 193: 752-58
11. Folch J, Lees M, Stanley GHS: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem, 1957; 226: 497-509
12. Quintans J, Kilkus J, McShan CL et al: Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem Biophys Res Commun, 1994; 202: 710-17
13. Sturm JC, Swenson KI, Turner JE, Bell RM: Ceramide triggers meiotic cell cycle progression in Xenopus Oocytes. A potential mediator of progesterone-induced maturation. J Biol Chem, 1995; 270: 13541-47
14. Okazaki T, Bell RM, Hannun YA: Sphingomyelin turnover induced by Vitamin DS in HL-60 Cells. Role in cell differentiation. J Biol Chem, 1989; 264: 19076-80
15. 3, analogue, calcipotriol, induces sphingomyelin hydrolysis in human keratinocytes. FEBS Lett, 1996; 378: 88-92
16. Babenko NA, Natarova YA: Role of thyroid hormones in regulation of sphingomyelin metabolism in the liver. Biochemistry (Moscow), 1999; 64: 912-15
17. Górska M, Dobrzyń A, Żendzian-Piotrowska M, Namiot Z: Concentration and composition of free ceramides in human plasma. Horm Metab Res, 2002; 34: 1-3
18. Samuelsson K: On the occurrence and nature of free ceramides in human plasma. Biochim Biophys Acta, 1969; 176: 211-13
19. Nillson A: Metabolism of sphingomyelin in the intestinal tract of the rat. Biochim Biophys Acta, 1968; 164: 575-84
20. Duan R-D: Sphingomyelin hydrolysis in the gut and clinical implications in colorectal tumorigenesis and other gastrointestinal diseases. Scand J Gastroenterol, 1998; 33: 673-83
21. Bouhours JF, Guignard H: Free ceramide, sphingomyelin, and glucosylceramide of isolated rat intestinal cells. J Lipid Res, 1979; 20: 897-907
22. Meyerzu Heringdorf D, van Koppen ChJ, Jakobs KH: Molecular diversity of sphingolipid signalling. FEBS Lett, 1997; 410: 34-38
23. Spiegel S, Merril AH Jr: Sphingolipid metabolism and cell growth regulation. FASEB J, 1996; 10: 1388-97