Fumonisin B1 increases serum sphinganine concentration but does not alter serum sphingosine concentration or induce cardiovascular changes in milk-fed calves

Toxicological Sciences

Volumn 60, Issue 2, 2001, Pages 379-384

  Mathur, Sheerin ^a   Constable, Peter D ^a   Eppley, Robert M ^b   Tumbleson, Mike E ^a   Smith, Geoffrey W ^a   Tranquilli, William J ^a   Morin, Dawn E ^a   Haschek, Wanda M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Cardiovascular toxicity; Fumonisin; Metabolic acidosis; Sphinganine; Sphingolipid; Sphingosine

Indexed keywords

FUMONISIN B2; SODIUM CHLORIDE; SPHINGANINE; SPHINGOSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL BLOOD; ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD LEVEL; BLOOD PH; CARDIOVASCULAR EFFECT; CATTLE; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; LUNG ARTERY PRESSURE; LUNG WEDGE PRESSURE; MALE; MEAN ARTERIAL PRESSURE; METABOLIC ACIDOSIS; MILK; NONHUMAN; OXYGEN SUPPLY; PLASMA VOLUME; SURVIVAL;

ACIDOSIS, RESPIRATORY; ANIMALS; ANIMALS, SUCKLING; CARBOXYLIC ACIDS; CATTLE; FUMONISINS; HEART VENTRICLES; HEMATOLOGIC TESTS; HEMODYNAMIC PROCESSES; INJECTIONS, INTRAVENOUS; MALE; MILK; MYCOTOXINS; MYOCARDIUM; SPHINGOSINE;

ANIMALIA; BOS TAURUS; EQUIDAE;

EID: 0035068647     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/60.2.379     Document Type: Article

References (21)

1. Chronic effects of dietary fumonisin on the heart and pulmonary vasculature of swine
2. 1-containing culture material decreases cardiac contractility and mechanical efficiency in swine
3. Acute hepatic and renal toxicity in lambs dosed with fumonisin-containing culture material
4. Effects of Fusarium moniliforme isolates on tissue and serum sphingolipid concentrations in horses
5. 1 in rabbits: Nephrotoxicity and sphingolipid alterations
6. 1 is hepatotoxic and nephrotoxic in milk-fed calves
7. Effects of fumonisin-contaminated corn screenings on growth and health of feeder calves
8. Characterization of an epizootic of pulmonary edema in swine associated with fumonisin in corn screenings
9. 1 in cows following a single dose by oral gavage or intravenous administration
10. Absence of detectable fumonisins in the milk of cows fed Fusarium proliferatum (Matsushima) Nirenberg culture material (1996)
11. 1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: A new mechanism of nephrotoxicity
12. Alteration of tissue and serum sphinganine to sphingosine ratio: An early biomarker to exposure to fumonisin-containing feeds in pigs
13. Liquid chromatographic determination of sphinganine and sphingosine ratio as a biomarker for consumption of fumonisins
14. Experimental equine leukoencephalomalacia, toxic hepatosis, and encephalopathy caused by corn naturally contaminated with fumonisins
15. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin containing Fusarium moniliforme culture material
16. 1 decreases cardiovascular function but does not alter pulmonary capillary permeability in swine
17. Cardiovascular responses to short-term fumonisin exposure in swine
18. Sequence of cardiovascular changes leading to pulmonary edema in swine fed culture material containing fumonisin
19. Hepatotoxicity and renal toxicity in rats, of corn samples associated with field cases of equine leukoencephalomalacia
20. A reliable, practical, and economical protocol for inducing diarrhea and severe dehydration in the neonatal calf
21. 1