-
1
-
-
0024955726
-
A special role for amsacrine in the treatment of acute leukemia
-
1. Arlin ZA (1989) A special role for amsacrine in the treatment of acute leukemia. Cancer Invest 7: 607
-
(1989)
Cancer Invest
, vol.7
, pp. 607
-
-
Arlin, Z.A.1
-
2
-
-
0021678126
-
Potential antitumor agents. Part 43. Synthesis and biological activity of dibasic 4-carboxamido-9-aminoacridines, a new class of antitumor agent
-
2. Atwell GJ, Cain BF, Baguley BC, Finlay GJ, Denny WA (1984) Potential antitumor agents. Part 43. Synthesis and biological activity of dibasic 4-carboxamido-9-aminoacridines, a new class of antitumor agent. J Med Chem 27: 1481
-
(1984)
J Med Chem
, vol.27
, pp. 1481
-
-
Atwell, G.J.1
Cain, B.F.2
Baguley, B.C.3
Finlay, G.J.4
Denny, W.A.5
-
3
-
-
0023251054
-
Potential antitumor agents. 50. In vivo solid tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
-
3. Atwell GJ, Rewcastle GW, Baguley BC, Denny WA (1987) Potential antitumor agents. 50. In vivo solid tumor activity of derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide. J Med Chem 30: 664
-
(1987)
J Med Chem
, vol.30
, pp. 664
-
-
Atwell, G.J.1
Rewcastle, G.W.2
Baguley, B.C.3
Denny, W.A.4
-
4
-
-
0021165002
-
Synthesis, antitumor activity, and DNA binding properties of a new derivative of amsacrine, N-5-dimethyl-9-[(2-methoxy-4-methylsulfonylamino)-phenylamino]-4-acridinecarboxamide
-
4. Baguley BC, Denny WA, Atwell GJ, Finlay GJ, Rewcastle GW, Twigden SJ, Wilson WR (1984) Synthesis, antitumor activity, and DNA binding properties of a new derivative of amsacrine, N-5-dimethyl-9-[(2-methoxy-4-methylsulfonylamino)-phenylamino]-4-acridinecarboxamide. Cancer Res 44: 3245
-
(1984)
Cancer Res
, vol.44
, pp. 3245
-
-
Baguley, B.C.1
Denny, W.A.2
Atwell, G.J.3
Finlay, G.J.4
Rewcastle, G.W.5
Twigden, S.J.6
Wilson, W.R.7
-
5
-
-
0033048874
-
Mechanism of cytotoxicity of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and of its 7-chloro derivative: The roles of topoisomerases I and II
-
5. Bridewell DJA, Finlay GJ, Baguley BC (1999) Mechanism of cytotoxicity of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II. Cancer Chemother Pharmacol 43: 302
-
(1999)
Cancer Chemother Pharmacol
, vol.43
, pp. 302
-
-
Bridewell, D.J.A.1
Finlay, G.J.2
Baguley, B.C.3
-
6
-
-
0016771313
-
Potential antitumor agents. Part 16. 4′-(Acridin-9-ylamino)methanesulfonanilides
-
6. Cain BF, Atwell GJ, Denny WA (1975) Potential antitumor agents. Part 16. 4′-(Acridin-9-ylamino)methanesulfonanilides. J Med Chem 18: 1110
-
(1975)
J Med Chem
, vol.18
, pp. 1110
-
-
Cain, B.F.1
Atwell, G.J.2
Denny, W.A.3
-
7
-
-
0028598336
-
Factors involved in clinical pharmacology variability in oncology
-
7. Chabot GG (1994) Factors involved in clinical pharmacology variability in oncology. Anticancer Res 14: 2269
-
(1994)
Anticancer Res
, vol.14
, pp. 2269
-
-
Chabot, G.G.1
-
8
-
-
0029840968
-
Comparative serum protein binding of anthracycline derivatives
-
8. Chassany O, Urien S, Claudepierre P, Bastian G, Tillement JP (1996) Comparative serum protein binding of anthracycline derivatives. Cancer Chemother Pharmacol 38: 571
-
(1996)
Cancer Chemother Pharmacol
, vol.38
, pp. 571
-
-
Chassany, O.1
Urien, S.2
Claudepierre, P.3
Bastian, G.4
Tillement, J.P.5
-
10
-
-
0015407723
-
Plasma camptothecin (NSC-100880) levels during a 5-day course of treatment: Relation to dose and toxicity
-
10. Creaven PJ, Allen LM, Muggia FM (1972) Plasma camptothecin (NSC-100880) levels during a 5-day course of treatment: relation to dose and toxicity. Cancer Chemother Rep 56: 573
-
(1972)
Cancer Chemother Rep
, vol.56
, pp. 573
-
-
Creaven, P.J.1
Allen, L.M.2
Muggia, F.M.3
-
11
-
-
0028157006
-
Renal secretion of vinblastine, vincristine and colchicine in vivo
-
11. de Lannoy IA, Mandin RS, Silverman M (1994) Renal secretion of vinblastine, vincristine and colchicine in vivo. J Pharm Exp Ther 268: 388
-
(1994)
J Pharm Exp Ther
, vol.268
, pp. 388
-
-
De Lannoy, I.A.1
Mandin, R.S.2
Silverman, M.3
-
12
-
-
0023267703
-
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid tumor activity
-
12. Denny WA, Atwell GJ, Rewcastle GW, Baguley BC (1987) Potential antitumor agents. 49. 5-Substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid tumor activity. J Med Chem 30: 658
-
(1987)
J Med Chem
, vol.30
, pp. 658
-
-
Denny, W.A.1
Atwell, G.J.2
Rewcastle, G.W.3
Baguley, B.C.4
-
13
-
-
0020393128
-
Protein binding of anthraquinone glycosides, with special reference to Adriamycin
-
13. Eksborg S, Ehrsson H, Ekqvist B (1982) Protein binding of anthraquinone glycosides, with special reference to Adriamycin. Cancer Chemother Pharmacol 10: 7
-
(1982)
Cancer Chemother Pharmacol
, vol.10
, pp. 7
-
-
Eksborg, S.1
Ehrsson, H.2
Ekqvist, B.3
-
14
-
-
0028158726
-
Plasma protein binding of the experimental antitumour agent acridine-4-carboxamide in man, dog, rat and rabbit
-
14. Evans SMH, Robertson IGC, Paxton JW (1994) Plasma protein binding of the experimental antitumour agent acridine-4-carboxamide in man, dog, rat and rabbit. J Pharm Pharmacol 46: 63
-
(1994)
J Pharm Pharmacol
, vol.46
, pp. 63
-
-
Evans, S.M.H.1
Robertson, I.G.C.2
Paxton, J.W.3
-
15
-
-
0027447244
-
In vitro assessment of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance
-
15. Finlay GJ, Marshall ES, Matthews JHL, Paull KD, Baguley BC (1993) In vitro assessment of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide, a DNA-intercalating antitumour drug with reduced sensitivity to multidrug resistance. Cancer Chemother Pharmacol 31: 401
-
(1993)
Cancer Chemother Pharmacol
, vol.31
, pp. 401
-
-
Finlay, G.J.1
Marshall, E.S.2
Matthews, J.H.L.3
Paull, K.D.4
Baguley, B.C.5
-
16
-
-
0029893321
-
From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine 4-carboxamide): Selectivity for topoisomerases I and II among acridine derivatives
-
16. Finlay GJ, Riou J-F, Baguley BC (1996) From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine 4-carboxamide): selectivity for topoisomerases I and II among acridine derivatives. Eur J Cancer 32 A: 708
-
(1996)
Eur J Cancer
, vol.32 A
, pp. 708
-
-
Finlay, G.J.1
Riou, J.-F.2
Baguley, B.C.3
-
18
-
-
0027787736
-
New approaches in preclinical and clinical pharmacokinetics
-
18. Graham MA, Kaye SB (1993) New approaches in preclinical and clinical pharmacokinetics. Cancer Surv 17: 27
-
(1993)
Cancer Surv
, vol.17
, pp. 27
-
-
Graham, M.A.1
Kaye, S.B.2
-
19
-
-
0023709403
-
A phase I trial of the amsacrine analog 9-[[2-methoxy-4-[(methylsulfonyl)amino]-phenyl]amino]-N,5-dimethyl-4-acridinecarboxamide (CI-921)
-
19. Hardy JR, Harvey VJ, Paxton JW, Evans PC, Smith S, Grillo-Lopez A, Grove W, Baguley BC (1988) A phase I trial of the amsacrine analog 9-[[2-methoxy-4-[(methylsulfonyl)amino]-phenyl]amino]-N,5-dimethyl-4-acridinecarboxamide (CI-921). Cancer Res 48: 6593
-
(1988)
Cancer Res
, vol.48
, pp. 6593
-
-
Hardy, J.R.1
Harvey, V.J.2
Paxton, J.W.3
Evans, P.C.4
Smith, S.5
Grillo-Lopez, A.6
Grove, W.7
Baguley, B.C.8
-
20
-
-
0026515566
-
Pharmacokinetic and pharmacodynamic studies with mitoxantrone in the treatment of patients with nasopharyngeal carcinoma
-
20. Hu OY, Chang SP, Law CK, Jian JM, Chen KY (1992) Pharmacokinetic and pharmacodynamic studies with mitoxantrone in the treatment of patients with nasopharyngeal carcinoma. Cancer 69: 847
-
(1992)
Cancer
, vol.69
, pp. 847
-
-
Hu, O.Y.1
Chang, S.P.2
Law, C.K.3
Jian, J.M.4
Chen, K.Y.5
-
21
-
-
0025124583
-
Disposition of amsacrine and its analogue 9-((2-methoxy-4-[(methylsulfonyl)-amino]phenyl)-amino)-N,5-dimethyl-4-acridinecarboxamide (CI-921) in plasma, liver, and Lewis lung tumors in mice
-
21. Kestell P, Paxton JW, Evans PC, Young D, Jurlina JL, Robertson IGC, Baguley BC (1990) Disposition of amsacrine and its analogue 9-((2-methoxy-4-[(methylsulfonyl)-amino]phenyl)-amino)-N,5-dimethyl-4-acridinecarboxamide (CI-921) in plasma, liver, and Lewis lung tumors in mice. Cancer Res 50: 503
-
(1990)
Cancer Res
, vol.50
, pp. 503
-
-
Kestell, P.1
Paxton, J.W.2
Evans, P.C.3
Young, D.4
Jurlina, J.L.5
Robertson, I.G.C.6
Baguley, B.C.7
-
22
-
-
0033056717
-
Plasma pharmacokinetics of N-[2-(dimethylamino)-ethyl]-acridine-4-carboxamide (DACA) in a phase I trial
-
22. Kestell P, Dunlop I, McCrystal MR, Evans BD, Paxton JW, Gamage RSKA, Baguley BC (1999) Plasma pharmacokinetics of N-[2-(dimethylamino)-ethyl]-acridine-4-carboxamide (DACA) in a phase I trial. Cancer Chemother Pharmacol 44: 45
-
(1999)
Cancer Chemother Pharmacol
, vol.44
, pp. 45
-
-
Kestell, P.1
Dunlop, I.2
McCrystal, M.R.3
Evans, B.D.4
Paxton, J.W.5
Gamage, R.6
Baguley, B.C.7
-
23
-
-
0023690101
-
Drug binding to human alpha-1-acid glycoprotein in health and disease
-
23. Kremer JM, Wilting J, Janssen LH (1988) Drug binding to human alpha-1-acid glycoprotein in health and disease. Pharmacol Rev 40: 1
-
(1988)
Pharmacol Rev
, vol.40
, pp. 1
-
-
Kremer, J.M.1
Wilting, J.2
Janssen, L.H.3
-
24
-
-
0027173117
-
Binding of taxol to human plasma, albumin and alpha-1-acid glycoprotein
-
24. Kumar GN, Walle UK, Bhalla KN, Walle T (1993) Binding of Taxol to human plasma, albumin and alpha-1-acid glycoprotein. Res Commun Chem Pathol Pharmacol 80: 337
-
(1993)
Res Commun Chem Pathol Pharmacol
, vol.80
, pp. 337
-
-
Kumar, G.N.1
Walle, U.K.2
Bhalla, K.N.3
Walle, T.4
-
25
-
-
0029153956
-
Etoposide protein binding in cancer patients
-
25. Liu B, Earl HM, Poole CJ, Dunn J, Kerr DJ (1995) Etoposide protein binding in cancer patients. Cancer Chemother Pharmacol 36: 506
-
(1995)
Cancer Chemother Pharmacol
, vol.36
, pp. 506
-
-
Liu, B.1
Earl, H.M.2
Poole, C.J.3
Dunn, J.4
Kerr, D.J.5
-
26
-
-
0032991591
-
Phase I study of the cytotoxic agent N-[2-dimethylamino)ethyl]acridine-4-carboxamide
-
26. McCrystal MR, Evans BD, Harvey VJ, Thompson PI, Porter DJ, Baguley BC (1999) Phase I study of the cytotoxic agent N-[2-dimethylamino)ethyl]acridine-4-carboxamide. Cancer Chemother Pharmacol 44: 39
-
(1999)
Cancer Chemother Pharmacol
, vol.44
, pp. 39
-
-
McCrystal, M.R.1
Evans, B.D.2
Harvey, V.J.3
Thompson, P.I.4
Porter, D.J.5
Baguley, B.C.6
-
27
-
-
0028150946
-
Marked interspecies variations concerning the interactions of camptothecin with serum albumins: A frequency-domain fluorescence spectroscopic study
-
27. Mi Z, Burke TG (1994) Marked interspecies variations concerning the interactions of camptothecin with serum albumins: a frequency-domain fluorescence spectroscopic study. Biochemistry 33: 12540
-
(1994)
Biochemistry
, vol.33
, pp. 12540
-
-
Mi, Z.1
Burke, T.G.2
-
30
-
-
0023790415
-
The clinical pharmacokinetics of N-5-dimethyl-9-[(2-methoxy-4-methyl-sulfhonylamino)phenylamino]-4-acridine carboxamide (CI-921) in a phase I trial
-
30. Paxton JW, Hardy JR, Evans PC, Harvey VJ, Baguley BC (1988) The clinical pharmacokinetics of N-5-dimethyl-9-[(2-methoxy-4-methyl-sulfhonylamino)phenylamino]-4-acridine carboxamide (CI-921) in a phase I trial. Cancer Chemother Pharmacol 22: 235
-
(1988)
Cancer Chemother Pharmacol
, vol.22
, pp. 235
-
-
Paxton, J.W.1
Hardy, J.R.2
Evans, P.C.3
Harvey, V.J.4
Baguley, B.C.5
-
31
-
-
0026754489
-
Variability in teniposide plasma protein binding is correlated with serum albumin concentrations
-
31. Petros WP, Rodman JH, Relling MV, Christensen M, Pui CH, Rivera GK, Evans WE (1992) Variability in teniposide plasma protein binding is correlated with serum albumin concentrations. Pharmacotherapy 12: 273
-
(1992)
Pharmacotherapy
, vol.12
, pp. 273
-
-
Petros, W.P.1
Rodman, J.H.2
Relling, M.V.3
Christensen, M.4
Pui, C.H.5
Rivera, G.K.6
Evans, W.E.7
-
32
-
-
0026677087
-
Protein binding of indomethacin, methotrexate and morphine in patients with cancer
-
32. Raveendran R, Heybroek WM, Caulfield M, Abrams SML, Wrigley PFM, Slevin M, Turner P (1992) Protein binding of indomethacin, methotrexate and morphine in patients with cancer. Int J Clin Pharmacol Res 12: 117
-
(1992)
Int J Clin Pharmacol Res
, vol.12
, pp. 117
-
-
Raveendran, R.1
Heybroek, W.M.2
Caulfield, M.3
Abrams, S.M.L.4
Wrigley, P.F.M.5
Slevin, M.6
Turner, P.7
-
33
-
-
0022540198
-
Potential antitumor agents. 46. Structure-activity relationships for acridine mono-substituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide
-
33. Rewcastle GW, Atwell GJ, Chambers D, Baguley BC, Denny WA (1986) Potential antitumor agents. 46. Structure-activity relationships for acridine mono-substituted derivatives of the antitumor agent N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide. J Med Chem 29: 472
-
(1986)
J Med Chem
, vol.29
, pp. 472
-
-
Rewcastle, G.W.1
Atwell, G.J.2
Chambers, D.3
Baguley, B.C.4
Denny, W.A.5
-
35
-
-
0031004973
-
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide
-
35. Spicer JA, Gamage SA, Atwell GJ, Finlay GJ, Baguley BC, Denny WA (1997) Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide. J Med Chem 40: 1919
-
(1997)
J Med Chem
, vol.40
, pp. 1919
-
-
Spicer, J.A.1
Gamage, S.A.2
Atwell, G.J.3
Finlay, G.J.4
Baguley, B.C.5
Denny, W.A.6
-
36
-
-
0025942640
-
pH-dependency of basic ligand binding to alpha 1-acid glycoprotein (orosomucoid)
-
36. Urien S, Bree F, Testa B, Tillement JP (1991) pH-dependency of basic ligand binding to alpha 1-acid glycoprotein (orosomucoid). Biochem J 280: 277
-
(1991)
Biochem J
, vol.280
, pp. 277
-
-
Urien, S.1
Bree, F.2
Testa, B.3
Tillement, J.P.4
-
37
-
-
0027389641
-
Effect of D,L -verapamil, verapamil enantiomers and verapamil metabolites on the binding of vincristine to alphal-acid glycoprotein
-
37. Woodcock BG, Abdelrahman MS, Wosch F, Harder S (1993) Effect of D,L -verapamil, verapamil enantiomers and verapamil metabolites on the binding of vincristine to alphal-acid glycoprotein. Eur J Cancer 29 A: 559
-
(1993)
Eur J Cancer
, vol.29 A
, pp. 559
-
-
Woodcock, B.G.1
Abdelrahman, M.S.2
Wosch, F.3
Harder, S.4
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