12th Annual Congress of the European Society of Gene Therapy

Expert Opinion on Biological Therapy

Volumn 5, Issue 1, 2005, Pages 137-141

  Read, Martin L ^a   Spice, Rachel ^c   Parker, Alan L ^b   Mir, Sohaib ^c   Logan, Ann ^c  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c NONE

Author keywords

dsRNA; Gene therapy; Genome editing; miRNA; Protein transduction domains; Reducible polycations; RNAi; siRNA; smRNA; Vectors

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ADENOVIRUS VECTOR; BLOOD CLOTTING FACTOR 9; CEREPRO; EG 009; GANCICLOVIR; GENE PRODUCT; KRUPPEL LIKE FACTOR 4; LENTIVIRUS VECTOR; MICRORNA; NITROREDUCTASE; POLYCATION; PROTEIN ALG2; PROTEIN VP22; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; THYMIDINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PIT 1; UNCLASSIFIED DRUG; VIRUS VECTOR; ZINC FINGER PROTEIN;

CANCER; CANCER THERAPY; CARCINOGENESIS; CLINICAL TRIAL; CONFERENCE PAPER; CONTINUING EDUCATION; FINLAND; GENE LIBRARY; GENE THERAPY; GENOME; GLIOBLASTOMA; HUMAN; MEDICAL RESEARCH; MEDICAL SOCIETY; NEWCASTLE DISEASE PARAMYXOVIRUS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHENOTYPE; PROTEIN DOMAIN; RNA INTERFERENCE; SAFETY; STEM CELL; SURVIVAL; TUMOR SUPPRESSOR GENE; ZINC FINGER MOTIF;

CLINICAL TRIALS AS TOPIC; GENE THERAPY; GENETIC VECTORS; HUMANS; RNA, SMALL INTERFERING; TECHNOLOGY, MEDICAL;

ADENOVIRIDAE; LENTIVIRUS; NEWCASTLE DISEASE VIRUS; PARAMYXOVIRIDAE;

EID: 12244262784     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.5.1.137     Document Type: Conference Paper

References (10)

1. READ ML, STEVENSON M, FARROW PJ et al.: RNA-based therapeutic strategies for cancer. Expert Opin. Ther. Patents (2003) 13:627-638.
2. READ ML, FARROW PJ, SEYMOUR LW: Emerging developments in RNA therapeutics. Expert Opin. Ther. Targets (2003) 7:299-303.
3. WADHWA R, KAUL SC, MIYAGISHI M et al.: Know-how of RNA interference and its applications in research and therapy. Mutat. Res. (2004) 567:71-84.
4. UI-TEI K, NAITO Y, TAKAHASHI F et al.: Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res. (2004) 32:936-948.
5. KAWASAKI H, TAIRA K: Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature (2004) 431:211-217. This paper describes a novel approach to gene silencing that uses siRNA targeting CpG islands in promoters.
6. KUWABARA T, HSIEH J, NAKASHIMA K et al.: A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell (2004) 116:779-793. This study reports on the gene activation effects of a short dsRNA that distinguish it from the cellular silencing effects of miRNA/siRNAs.
7. HE L, HANNON GJ: MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet. (2004) 5:522-531. An excellent review describing microRNAs in mammalian systems.
8. JENKE AC, STEHLE IM, HERRMANN F et al.: Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome. Proc. Natl. Acad. Sci. USA (2004) 101:11322-11327.
9. READ ML, BREMNER KH, OUPICKY D et al.: Vectors based on reducible polycations facilitate intracellular release of nucleic acids. J. Gene Med. (2003) 5:232-245.
10. SCACHERI PC, ROZENBLATT-ROSEN O, CAPLEN NJ et al.: Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc. Natl. Acad. Sci. USA (2004) 101:1892-1897. This report highlights how siRNA can induce nonspecific effects on protein levels.