Folate intake, plasma folate and homocysteine status in a random Finnish population

European Journal of Clinical Nutrition

Volumn 57, Issue 1, 2003, Pages 81-88

  Alfthan, Georg ^a   Laurinen, M S ^a   Valsta, L M ^a   Pastinen, T ^a,b   Aro, A ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b Montreal Centre Region   (Canada)

Author keywords

Dietary intake; Folate status; Homocysteine; MTHFR; Vitamin B12

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; BREAD; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIETARY INTAKE; DNA DETERMINATION; FEMALE; FINLAND; FOOD INTAKE; FRUIT; GENOTYPE; HEALTH STATUS; HEALTH SURVEY; HOMOZYGOSITY; HUMAN; MALE; POPULATION RESEARCH; POTATO; RYE; VEGETABLE; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION;

ADULT; AGED; BIOLOGICAL MARKERS; DIET; DIETARY SUPPLEMENTS; FEMALE; FINLAND; FOLIC ACID; GENOTYPE; HOMOCYSTEINE; HOMOZYGOTE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; NUTRITIONAL STATUS; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; VITAMIN B 12;

SECALE CEREALE; SOLANUM TUBEROSUM;

EID: 12244255773     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1601507     Document Type: Article

References (48)

1. Alfthan G, Pekkanen J, Jauhiainen M, Pitkäniemi J, Karvonen M, Tuomilehto J, Salonen JT & Ehnholm C (1994): The relation of serum homocysteine and lipoprotein (a) concentrations to atherosclerotic disease in a Finnish population-based cohort. Atherosclerosis 106, 9-19.
2. Appel LJ, Miller ER III, Jee SH, Stolzenberg-Solomon R, Lin PH, Erlinger T, Nadeau MR & Selhub J (2000). Effect of dietary patterns on serum homocysteine. Results of a randomized, controlled feeding study. Circulation 102, 852-857.
3. Bell GI, Karam JH & Rutter WJ (1981): Polymorphic DNA region adjacent to the 5′ end of the human insulin gene. Proc. Natl Acad. Sci. 78, 5759-5763.
4. Bergström L (1994). Nutrient losses and gains in the preparation of foods. National Food Administration. (Report 32. Uppsala:)
5. Boushey, CJ, Beresford SAA, Omenn GS & Motulsky AG (1995): A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 274, 1049-1057.
6. Brattström L, Wilcken DEL, Ohrvik J & Brudin L (1998): Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease. Circulation 98, 2520-2526.
7. Brouwer DAJ, Welten HTME, Reijngoud D-J, van Doormaal JJ & Muskiet FAJ (1998). Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine. Clin. Chem. 44, 1545-1550.
8. Brouwer IA, van Dusseldorp M, Thomas CMG, Duran M, Hautvast JGAJ, Eskes TKAB & Steegers-Theunissen RPM (1999a): Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. Am. J. Clin. Nutr. 69, 99-104.
9. Brouwer IA, van Dusseldorp M, West CE, Meyboom S, Thomas CMG, Duran M, van het Hof KH, Eskes TKAB, Hautvast JGAJ & Steerers-Theunissen RPM (1999b). Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. J. Nutr. 129, 1135-1139.
10. Brussaard JH, Löwik MRH, van den Berg H, Brants HAM & Goldbohm RA (1997): Folate intake and status among adults in the Netherlands. Eur. J. Clin. Nutr. 51, S46-S50.
11. Christen WG, Ajani UA, Glynn RJ & Hennekens CH (2000): Blood levels of homocysteine and increased risks of cardiovascular disease. Causal or casual? Arch. Intern. Med. 160, 422-434.
12. Czeizel AE & Dudas I (1992): Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation. New Engl. J. Med. 327, 1832-1835.
13. FINDIET Study Group (1998): The 1997 dietary survey of Finnish adults. Publication B8. Helsinki: National Public Health Institute.
14. Frosst P, Blom HJ, Milos U, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuvel LP & Rozen R (1995): A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat. Genet. 10, 111-113.
15. Gregory JF III (1997): Bioavailability of folate. Eur. J. Clin. Nutr. 51(Suppl 1), 554-559.
16. den Heijer M, Brouwer IA, Bos GMJ, Blom HJ, van der Put NMJ, Spaans AP, Rosendaal FR, Thomas CMG, Haak HL, Wijermans PW & Gerrits WBJ (1998): Vitamin supplementation reduces blood homocysteine levels. A controlled trial in patients with venous thrombosis and healthy volunteers. Arterioscl. Thromb. Vasc. Biol. 18, 356-361.
17. Homocysteine Lowering Trialists' Collaboration (1998): Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Br. Med. J. 316, 894-898.
18. Jacob RA, Wu MM, Henning SM & Swendseid ME (1994). Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction. J. Nutr. 124, 1072-1080.
19. Jacques PF, Selhub J, Bostom AG, Wilson PWF & Rosenberg IH (1999): The effect of folic acid fortification on plasma folate and total homocysteine concentrations. New Engl. J. Med. 340, 1449-1454.
20. Knekt P, Reunanen A, Alfthan G, Heliövaara M, Rissanen H, Marniemi J & Aromaa A (2001a). Hyperhomocysteinemia-a risk factor or a consequence of coronary heart disease? Arch. Intern. Med. 161, 1589-1594.
21. Knekt P, Alfthan G, Aromaa A, Heliövaara M, Marniemi J, Rissanen H & Reunanen A (2001b). Homocysteine and major coronary events: a prospective population study among women. J. Intern. Med. 249, 461-465.
22. Konings EJM, Roomans HHS, Dorant E, Goldbohm RA, Saris WHM & van den Brandt PA (2001): Folate intake of the Dutch population according to newly established liquid chromatographic data for foods. Am. J. Clin, Nutr. 73, 765-776.
23. Lewis CA, Pancharuniti N & Sauberlich HE (1992): Plasma folate adequacy as determined by homocysteine level. Ann. NY Acad. Sci. 669, 360-362.
24. Mills JL, Tuomilehto J, Yu KF, Colman N, Blaner WS, Koskela P, Rundle WE, Forman M, Toivanen L & Rhoads GG (1992): Maternal vitamin levels during pregnancies producing infants with neural tube defects. J. Pediatr. 120, 863-871.
25. Möller J, Rasmussen K & Christensen L (1999): External quality assessment of methylmalonic and total homocysteine. Clin. Chem. 45, 1536-1542.
26. Motti C, Gnasso A, Bernardini S, Massoud R, Pastore A, Rampa P, Federici G & Cortese C (1998): Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine and other risk factors for vascular disease. Atherosclerosis 139, 377-383.
27. MRC Vitamin Study Research Group (1991): Prevention of neural tube defects: results of the Medical Research Council Vitamin study. Lancet 338, 131-137.
28. Ovaskainen ML (2001): Fineli® Elintarvikkeiden koostumustietopankki, www.ktl.fi/fineli >.2001 (in Finnish).
29. Pastinen T, Perola M, Niini P, Terwilliger J, Salomaa V, Vartiainen E, Peltonen L & Syvänen A-C (1998). Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population. Hum. Mol. Genet. 7, 1453-1462.
30. 12 status of the elderly. Eur. J. Clin. Nutr. 50, 340-342.
31. Rady PL, Tyring SK, Hudnall D, Vargas T, Kellner LH, Nitowsky H & Matalon RK (1999): Methylenetetrahydrofolate reductase (MTHFR): the incidence of mutations C677T and A1298C in the Ashkenazi Jewish population. Am. J. Med. Genet. 86, 380-384.
32. Rasmussen LB, Ovesen L, Bulow I, Knudsen N, Laurberg P & Perrild H (2000): Folate intake, lifestyle factors, and homocysteine concentrations in younger and older women. Am. J. Clin. Nutr. 72, 1156-1163.
33. Riddell LJ, Chisholm A, Williams S & Mann JI (2000): Dietary strategies for lowering homocysteine concentrations. Am. J. Clin. Nutr. 71, 1448-1454.
34. Ridker PM, Hennekens CH, Selhub J, Miletich JP, Malinow MR & Stampfer MJ (1997): Interrelation of hyperhomocyst(e)inemia, factor V Leiden and risk of future venous thromboembolism. Circulation 95, 1777-1782.
35. 6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 279, 359-364.
36. Ritvanen A (1996): Neural tube defects and folic acid. Duodecim 112, 975-982(in Finnish).
37. Sandström B & Gibney M (2001): A framework for food-based dietary guidelines in the European Union. Public Health Nutr. 4(2A), 293-305.
38. Scholl TO & Johnson WG (2000): Folic acid: influence on the outcome of pregnancy. Am. J. Clin. Nutr. 71(Suppl), 1295S-1303S.
39. Selhub J, Jacques PS, Rosenburg IH, Rogers G, Bowman BA, Gunter EW, Wright JD & Johnson CL (1999): Serum total homocysteine concentrations in the Third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann. Intern. Med. 131, 331-339.
40. Syvänen AC, Sajantila A & Lukka M (1993): Identification of individuals by analysis of biallelic DNA markers, using PCR and solid-phase minisequencing. Am. J. Hum. Genet, 52, 46-59.
41. Tucker KL, Selhub J, Wilson PWF & Rosenburg IH (1996): Dietary intake pattern relates to plasma folate and homocysteine concentrations in the Framingham Heart Study. J. Nutr. 126, 3025-3031.
42. Ubbink JB, Haywaard Vermaak WJ & Bissbort S (1991): Rapid high-performance liquid chromatography assay for total homocysteine levels in human serum. J. Chromatogr. 565, 441-446.
43. Vahteristo LT, Lehikoinen KE, Ollilainen V, Koivistoinen PE & Varo P (1998): Oven-baking and frozen storage affect folate vitamer retention. Lebensm. Wiss. Technol. 31, 329-333.
44. Vartiainen E, Jousilahti P, Alfthan G, Sundvall J, Pietinen P & Puska P (2000): Cardiovascular risk factor changes in Finland, 1972-1997. Int. J. Epidemiol. 29, 49-56.
45. Voutilainen S, Lakka TA, Hämelahti P, Lehtimäki T, Poulsen HE & Salonen JT (2000): Plasma total homocysteine and the risk of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. J. Intern. Med. 248, 217-222.
46. Voutilainen S, Rissanen T, Virtanen J, Lakka TA & Salonen JT (2001): Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation 103, 2674-2680.
47. Wirta V, Huang XH, Wirta 0, Rantalaiho V, Pasternack A, Jokela H, Koivula T & Lehtimäki T (1998). Mutation C677T of methylenetetrahydrofolate reductase gene is not associated with coronary artery disease, but possibly with albuminuria, in type 2 diabetic patients. Clin. Chem. Lab. Med. 36, 625-628.
48. Woo KS, Chook P, Lolin YI, Cheung ASP, Chan LT, Sun YY, Sanderson JE, Metreweli C & Celermajer DS (1997): Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfynction in humans. Circulation 96, 2542-2544.