Molecular Characterization of the Principal Substrate Binding Site of the Ubiquitous Folding Catalyst Protein Disulfide Isomerase

Journal of Biological Chemistry

Volumn 279, Issue 11, 2004, Pages 10374-10381

  Pirneskoski, Annamari ^a,b   Klappa, Peter ^b   Lobell, Mario ^b   Williamson, Richard A ^b   Byrne, Lee ^b   Alanen, Heli I ^a   Salo, Kirsi E H ^a   Kivirikko, Kari I ^a   Freedman, Robert B ^b,c   Ruddock, Lloyd W ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF KENT   (United Kingdom)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; ENZYMES; MOLECULAR STRUCTURE; OXIDATION; POLYPEPTIDES; SUBSTRATES;

ENDOPLASMIC RETICULUM; EUCARYOTES;

BIOCHEMISTRY;

DISULFIDE; DITHIOL DERIVATIVE; POLYPEPTIDE; PROTEIN DISULFIDE ISOMERASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; DISULFIDE BOND; ENDOPLASMIC RETICULUM; ENZYME ANALYSIS; GENE MUTATION; MOLECULAR MODEL; NONHUMAN; OUTER MEMBRANE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN SECRETION; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; RESIDUE ANALYSIS;

BINDING SITES; BIOPHYSICS; BLOTTING, WESTERN; CATALYSIS; CIRCULAR DICHROISM; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI; GENETIC VECTORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTATION; OXYGEN; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DISULFIDE-ISOMERASE; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; THIOREDOXIN; ULTRAVIOLET RAYS;

ANIMALIA; EUKARYOTA;

EID: 12144288546     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312193200     Document Type: Article

References (34)

1. Goldberger, R. F., Epstein, C. J., and Anfinsen, C. B. (1963) J. Biol. Chem. 238, 628-635
2. Freedman, R. B., Klappa, P., and Ruddock, L. W. (2002) EMBO Rep. 3, 136-140
3. Anelli, T., Alessio, M., Mezghrani, A., Simmen, T., Talamo, F., Bachi, A., and Sitia, R. (2002) EMBO J. 21, 835-844
4. Ferrari, D. M., Nguyen Van, P., Kratzin, H. D., and Söhling, H. D. (1998) Eur. J. Biochem. 255, 570-579
5. Cunnea P. M., Miranda-Vizuete, A., Bertoli, G., Simmen, T., Damdimopoulos, A. E., Hermann, S., Leinonen, S., Huikko, M. P., Gustafsson, J. A., Sitia, R., and Spyrou, G. (2003) J. Biol. Chem. 278, 1059-1066
6. Alanen, H. I., Williamson, R. A., Howard, M. J., Lappi, A. K., Jäntti, H. P., Rautio, S. M., Kellokumpu, S., and Ruddock, L. W. (2003) J. Biol. Chem. 278, 28912-28920
7. Ferrari, D. M., and Söling, H-D. (1999) Biochem. J. 339, 1-10
8. Kemmink, J., Darby, N. J., Dijkstra, K., Nilges, M., and Creighton, T. E. (1996) Biochemistry 35, 7684-7691
9. Kemmink, J., Darby, N. J., Dijkstra, K., Nilges, M., and Creighton, T. E. (1997) Curr. Biol. 7, 239-245
10. Freedman, R. B., Gane, P. J., Hawkins, H. C., Hlodan, R., McLaughlin, S. H., and Parry, J. W. (1998) Biol. Chem. 379, 321-328
11. Alanen, H. I., Salo, K. E. H., Pekkala, M., Siekkinen, H. M., Pirneskoski, A., and Ruddock, L. W. (2003) Antiox. Redox Signal. 5, 367-377
12. Darby, N. J., Penka, E., and Vincentelli, R. (1998) J. Mol. Biol. 276, 239-247
13. Klappa, P., Ruddock, L. W., Darby, N. J., and Freedman, R. B. (1998) EMBO J. 17, 927-935
14. Ruddock, L. W., Freedman, R. B., and Klappa, P. (2000) Protein Sci. 9, 758-764
15. Klappa, P., Freedman, R. B., Langenbuch, M., Lan, M. S., Robinson, G. K., and Ruddock, L. W. (2001) Biochem. J. 354, 553-559
16. Rost, B. (1996) Methods Enzymol. 266, 525-539
17. Sander, C., and Schneider, R. (1991) Proteins 9, 56-68
18. Frishman, D., and Argos, P. (1997) Proteins 27, 329-335
19. Gane, P. G. (1996) A Sequence, Structure, and Electrostatic Analysis of the Disulfide Oxidoreductases. Ph.D. thesis, University of Kent, Canterbury, UK
20. Corpet, F. (1988) Nucleic Acids Res. 16, 10881-10890
21. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
22. Tsai, B., Rodighiero, C., Lencer, W. I., and Rappaport, T. A. (2001) Cell 104, 937-948
23. Lumb, R. A., and Bulleid, N. J. (2002) EMBO J., 21, 6763-6770
24. Kemmink, J., Darby, N. J., Dijkstra, K., Nilges, M., and Creighton, T. E. (1999) J. Biomol. NMR 13, 357-368
25. Katti, S. K., LeMaster, D. M., and Eklund, H. (1990) J. Mol. Biol. 212, 167-184
26. Forman-Kay, J. D., Clore, G. M., Wingfield, P. T., and Gronenborn, A. M. (1991) Biochemistry 30, 2685-2698
27. Klappa, P., Hawkins, H. C., and Freedman, R. B. (1997) Eur. J. Biochem. 248, 37-42
28. Koivunen, P., Pirneskoski, A., Karvonen, P., Ljung, J., Helaakoski, T., Notbohm, H., and Kivirikko, K. I. (1999) EMBO J., 18, 65-74
29. Klappa, P., Koivunen, A., Pirneskoski, A., Karvonen, P., Ruddock, L. W., Kivirikko, K. I., and Freedman, R. B. (2000) J. Biol. Chem. 275, 13213-13218
30. Blank, J., Kupke, T., Lowe, E., Barth, P., Freedman, R. B., and Ruddock, L. W. (2003) Antiox. Redox. Signal. 5, 359-366
31. Lappi, A. K., Lensink, M., Alanen, H. I., Salo, K. E. H., Lobell, M., Juffer, A., and Ruddock, L. W. (2004) J. Mol. Biol. 333, 283-295
32. Dyson, H. J., Jeng, M. F., Tennant, L. L., Slaby, I., Lindell, M., Cui, D. S., Kuprin, S., and Holmgren, A. (1997) Biochemistry 36, 2622-2636
33. LeMaster, D. M., Springer, P. A., and Unkefer, C. J. (1997) J. Biol. Chem. 272, 29998-30001
34. Kanai, S., Toh, H., Hayano, T., and Kikychi, M. (1998) J. Mol. Evol. 47, 200-210