Thermodynamic Analysis of the Activation Mechanism of the GCSF Receptor Induced by Ligand Binding

Biochemistry

Volumn 43, Issue 9, 2004, Pages 2458-2464

  Mine, Shouhei ^a,d   Koshiba, Takumi ^b   Honjo, Eijiro ^a   Okamoto, Tomoyuki ^a   Tamada, Taro ^a   Maeda, Yoshitake ^a   Matsukura, Yasuko ^a   Horie, Akane ^a   Ishibashi, Matsujiro ^c   Sato, Miharu ^a   Azuma, Mizue ^a   Tokunaga, Masao ^c   Nitta, Katsutoshi ^b   Kuroki, Ryota ^a  

^a KIRIN BREWERY CO LTD   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALORIMETRY; CHEMICAL ACTIVATION; CRYSTAL STRUCTURE; ISOTHERMS; LIGHT SCATTERING; STOICHIOMETRY; THERMODYNAMICS;

LIGAND BINDING;

BIOCHEMISTRY;

CYTOKINE RECEPTOR; DIMER; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN FC FRAGMENT; MONOMER;

ARTICLE; CALORIMETRY; CRYSTAL STRUCTURE; LIGAND BINDING; LIGHT SCATTERING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR UPREGULATION; SURFACE PROPERTY; THERMODYNAMICS;

ANIMALS; BACULOVIRIDAE; CALORIMETRY; CHROMATOGRAPHY, GEL; GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; LIGANDS; LIGHT; MICE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOKINE; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR; RECOMBINANT FUSION PROTEINS; SCATTERING, RADIATION; SOLUTIONS; SPODOPTERA; STRUCTURAL HOMOLOGY, PROTEIN; THERMODYNAMICS;

EID: 12144286891     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0356855     Document Type: Article

References (34)

1. Nagata, S., Tsuchiya, M., Asano, S., Kaziro, Y., Yamazaki, T., Yamamoto, O., Hirata, Y., Kubota, N., Oheda, M., Nomura, H., and Ono, M. (1986) Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor, Nature 319, 415-418.
2. Fukunaga, R., Ishizaka-Ikeda, E., Seto, Y., and Nagata, S. (1990) Expression cloning of a receptor for murine granulocyte colony-stimulating factor, Cell 61, 341-350.
3. Fukunaga, R., Seto, Y., Mizushima, S., and Nagata, S. (1990) Three different mRNAs encoding human granulocyte colony-stimulating factor receptor, Proc. Natl. Acad. Sci. U.S.A. 87, 8702-8706.
4. Avalos, B. R. (1996) Molecular analysis of the granulocyte colony-stimulating factor receptor, Blood 88, 761-777.
5. Fukunaga, R., Ishizaka-Ikeda, E., Pan, C. X., Seto, Y., and Nagata, S. (1991) Functional domains of the granulocyte colony-stimulating factor receptor, EMBO J. 10, 2855-2865.
6. Hammacher, A., Richardson, R. T., Layton, J. E., Smith, D. K., Angus, L. J., Hilton, D. J., Nicola, N. A., Wijdenes, J., and Simpson, R. J. (1998) The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor, J. Biol. Chem. 273, 22701-22707.
7. Layton, J. E., Iaria, J., Smith, D. K., and Treutlein, H. R. (1997) Identification of a ligand-binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis, J. Biol. Chem. 272, 29735-29741.
8. Horan, T., Wen, J., Narhi, L., Parker, V., Garcia, A., Arakawa, T., and Philo, J. (1996) Dimerization of the extracellular domain of granuloycte-colony stimulating factor receptor by ligand binding: a monovalent ligand induces 2:2 complexes, Biochemistry 35, 4886-4896.
9. Horan, T. P., Martin, F., Simonet, L., Arakawa, T., and Philo, J. S. (1997) Dimerization of granulocyte-colony stimulating factor receptor: the Ig plus CRH construct of granulocyte-colony stimulating factor receptor forms a 2: 2 complex with a ligand, J. Biochem. 121, 370-375.
10. Aritomi, M., Kunishima, N., Okamoto, T., Kuroki, R., Ota, Y., and Morikawa, K. (1999) Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme, Nature 401, 713-717.
11. Hiraoka, O., Anaguchi, H., Asakura, A., and Ota, Y. (1995) Requirement for the immunoglobulin-like domain of granulocyte colony-stimulating factor receptor in formation of a 2:1 receptor-ligand complex, J. Biol. Chem. 270, 25928-25934.
12. Layton, J. E., Shimamoto, G., Osslund, T., Hammacher, A., Smith, D. K., Treutlein, H. R., and Boone, T. (1999) Interaction of granulocyte colony-stimulating factor (G-CSF) with its receptor. Evidence that Glu19 of G-CSF interacts with Arg288 of the receptor, J. Biol. Chem. 274, 17445-17451.
13. Layton, J. E., Iaria, J., and Nicholson, S. E. (1997) Neutralising antibodies to the granulocyte colony-stimulating factor receptor recognise both the immunoglobulin-like domain and the cytokine receptor homologous domain, Growth Factors 14, 117-130.
14. Chow, D., He, X., Snow, A. L., Rose-John, S., and Garcia, K. C. (2001) Structure of an extracellular gp130 cytokine receptor signaling complex, Science 291, 2150-2155.
15. Ishibashi, M., Tokunaga, H., Arakawa, T., and Tokunaga, M. (2001) Expression, purification, and characterization of the active immunoglobulin-like domain of human granulocyte-colony-stimulating factor receptor in Escherichia coli, Protein Expression Purif. 21, 317-322.
16. Tahara, T., Kuwaki, T., Matsumoto, A., Morita, H., Watarai, H., Inagaki, Y., Ohashi, H., Ogami, K., Miyazaki, H., and Kato, T. (1998) Native thrombopoietin: structure and function, Stem Cells 16, 54-60.
17. Xie, D., and Freire, E. (1994) Molecular basis of cooperativity in protein folding. V. Thermodynamic and structural conditions for the stabilization of compact denatured states, Proteins 19, 291-301.
18. Murphy, K. P., and Freire, E. (1992) Thermodynamics of structural stability and cooperative folding behavior in proteins, Adv. Protein Chem. 43, 313-361.
19. Haniu, M., Horan, T., Arakawa, T., Le, J., Katta, V., Hara, S., and Rohde, M. F. (1996) Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor, Biochemistry 35, 13040-13046.
20. Hiraoka, O., Anaguchi, H., and Ota, Y. (1994) Evidence for the ligand-induced conversion from a dimer to a tetramer of the granulocyte colony-stimulating factor receptor, FEBS Lett. 356, 255-260.
21. Spolar, R. S., and Record, M. T., Jr. (1994) Coupling of local folding to site-specific binding of proteins to DNA, Science 263, 777-784.
22. Livingstone, J. R., Spolar, R. S., and Record, M. T., Jr. (1991) Contribution to the thermodynamics of protein folding from the reduction in water-accessible nonpolar surface area, Biochemistry 30, 4237-4244.
23. + reductase and the role of water at the complex interface, Biochemistry 33, 13321-13328.
24. Stites, W. E. (1997) Protein-Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis, Chem. Rev. 97, 1233-1250.
25. Murphy, K. P., Freire, E., and Peterson, Y. (1995) Configurational effects in antibody-antigen interactions studied by microcalorimetry, Proteins 21, 83-90.
26. Murphy, K. P., Privalov, P. L., and Gill, S. J. (1990) Common features of protein unfolding and dissolution of hydrophobic compounds, Science 247, 559-561.
27. Layton, J. E., Hall, N. E., Connell, F., Venhorst, J., and Treutlein, H. R. (2001) Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor, J. Biol. Chem. 276, 36779-36787.
28. Reidhaar-Olson, J. F., De Souza-Hart, J. A., and Selick, H. E. (1996) Identification of residues critical to the activity of human granulocyte colony-stimulating factor, Biochemistry 35, 9034-9041.
29. Young, D. C., Zhan, H., Cheng, Q. L., Hou, J., and Matthews, D. J. (1997) Characterization of the receptor binding determinants of granulocyte colony stimulating factor, Protein Sci. 6, 1228-1236.
30. Livnah, O., Stura, E. A., Johnson, D. L., Middleton, S. A., Mulcahy, L. S., Wrighton, N. C., Dower, W. J., Jolliffe, L. K., and Wilson, I. A. (1996) Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 Å, Science 273, 464-471.
31. Syed, R. S., Reid, S. W., Li, C., Cheetham, J. C., Aoki, K. H., Liu, B., Zhan, H., Osslund, T. D., Chirino, A. J., Zhang, J., Finer-Moore, J., Elliott, S., Sitney, K., Katz, B. A., Matthews, D. J., Wendoloski, J. J., Egrie, J., and Stroud, R. M. (1998) Efficiency of signalling through cytokine receptors depends critically on receptor orientation, Nature 395, 511-516.
32. Livnah, O., Johnson, D. L., Stura, E. A., Farrell, F. X., Barbone, F. P., You, Y., Liu, K. D., Goldsmith, M. A., He, W., Krause, C. D., Pestka, S., Jolliffe, L. K., and Wilson, I. A. (1998) An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation, Nat. Struct. Biol. 5, 993-1004.
33. Livnah, O., Stura, E. A., Middleton, S. A., Johnson, D. L., Jolliffe, L. K., and Wilson, I. A. (1999) Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation, Science 283, 987-990.
34. Remy, I., Wilson, I. A., and Michnick, S. W. (1999) Erythropoietin receptor activation by a ligand-induced conformation change, Science 283, 990-993.