A novel dysfunctional growth hormone variant (Ile179Met) exhibits a decreased ability to activate the extracellular signal-regulated kinase pathway

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 3, 2004, Pages 1068-1075

  Lewis, Mark D ^a   Horan, Martin ^a   Millar, David S ^a   Newsway, Vicky ^a   Easter, Tammy E ^a   Fryklund, Linda ^b   Gregory, John W ^a   Norin, Martin ^c   Del Valle, Cristóbal Jorge ^d   López Siguero, Juan Pedro ^f   Cañete, Ramón ^g   López Canti, Luis Fernando ^e   Díaz Torrado, Nieves ^h   Espino, Rafael ⁱ   Ulied, Angels ^j   Scanlon, Maurice F ^a   Procter, Annie M ^a   Cooper, David N ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b PFIZER INC   (United States)

^c BIOVITRUM AB   (Sweden)

^d Hospital Militar   (Spain)

^e HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^f HOSPITAL MATERNO INFANTIL   (Spain)

^g HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^h HOSPITAL INFANTA ELENA   (Spain)

ⁱ HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^j I3 Research   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; ISOLEUCINE; METHIONINE; MITOGEN ACTIVATED PROTEIN KINASE; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHILD; CONTROLLED STUDY; ENZYME ACTIVATION; FAMILIAL DISEASE; GENE EXPRESSION; GENE MUTATION; GENETIC SCREENING; GENETIC VARIABILITY; HORMONE ACTION; HUMAN; HYPOPHYSIS CELL; MAJOR CLINICAL STUDY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RAT; RECEPTOR BINDING; SHORT STATURE; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; WILD TYPE;

BODY HEIGHT; CHILD; CRYSTALLOGRAPHY, X-RAY; GENETIC SCREENING; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; POINT MUTATION; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY;

ANIMALIA;

EID: 12144286594     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030652     Document Type: Article

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