Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in patients with essential tremor in Turkey

Movement Disorders

Volumn 19, Issue 12, 2004, Pages 1472-1476

  Sazci, Ali ^a   Ergul, Emel ^a   Bayulkem, Kemal ^a  

^a KOCAELI UNIVERSITY   (Turkey)

Author keywords

Association; Essential tremor; Genotyping; MTHFR; Polymorphism; Turkey

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ADENINE; CYTOSINE; THYMINE;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ESSENTIAL TREMOR; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STATISTICAL ANALYSIS; TURKEY (REPUBLIC);

ADULT; DNA PRIMERS; ESSENTIAL TREMOR; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, GENETIC; TURKEY;

EID: 12144283942     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.20254     Document Type: Article

References (36)

1. Dana CL. Hereditary tremor, a hitherto undescribed form of motor neurosis. Am J Med Sci 1887;94:386-393.
2. Findly U. Epidemiology and genetics of essential tremor. Neurology 2000;54(Suppl. 4):S8-S13.
3. Pahwa R, Lyons KE. Essential tremor: differential diagnosis and current tberapy. Am J Med 2003;115:134-142.
4. Chen JJ, Swope DM. Essential tremor: diagnosis and treatment. Pharmacotherapy 2003;23:1105-1122.
5. Gulcher JR, Jonsson P, Kong A, et al. Mapping of a familial essential tremor gene, FET1, to chromosome 3q13. Nat Genet 1997;17:84-87.
6. Higgins JJ, Pho LT, Nee LE. A gene (ETM) for essential tremor maps to chromosome 2p22-p25. Mov Disord 1997;12:859-864.
7. Pigullo S, Maria ED, Marchese R, et al. No evidence of association between CAG expansions and essential tremor in a large cohort of Italian patients. J Neural Transm 2001;108:297-304.
8. Rozen R. Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost 1997;78:21-23.
9. Goyette P, Pai A, Milos R, et al. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome 1998;9:652-656.
10. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-113.
11. Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 1998;64:169-172.
12. van der Put N, Gabreels F, Stevens EMB, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural tube defects? Am J Hum Genet 1998;62:1044-1051.
13. Fletcher O, Kessling AM. MTHFR association with atherosclerotic vascular disease? Hum Genet 1998;103:11-12.
14. Morita H, Taguchi L, Kurihra H, et al. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor for coronary artery disease. Circulation 1997;95:2032-2036.
15. Botto DL, Yang Q. 5,10-methylenetetrahydrofolate reductase gene variants and congenital anomalies. A HuGE review. Am J Epidemiol 2000;151:862-877.
16. Kluijtmans LAJ, van den Heuvel LP, Boers JH, et al. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 1996;58: 35-41.
17. Kara I, Sazci A, Ergul E, Kaya G, Kilic G. Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Brain Res Mol Brain Res 2003;111:84-90.
18. Nakaso K, Yasui K, Kowa H, et al. Hypertrophy of IMC of carotid artery in Parkinson's disease is associated with L-dopa, homocysteine, and MTHFR genotype. J Neurol Sci 2003;207:19-23.
19. Yasui K, Kowa H, Nakaso K, Takeshima T, Nakashima K. Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD. Neurology 2000;55:437-440.
20. Pollak RD, Pollak A, Idelson M, Bejarano-Achache I, Doron D, Blumenfeld A. The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and vascular dementia. J Am Geriatr Soc 2000;48:664-668.
21. Chapman J, Wang N, Treves TA, Korczyn AD, Bornstein NM. ACE, MTHFR, factor V Leiden, and APOE polymorphisms in patients with vascular and Alzheimer's dementia. Stroke 1998;29: 1401-1414.
22. Sazci A, Ergul E, Guzelhan Y, Kaya G, Kara I. Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia. Brain Res Mol Brain Res 2003;117:104-107.
23. Muntjewerff JW, van der Put N, Eskes T, et al. Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia. Psychiatry Res 2003;121:1-9.
24. Louis ED, Ford B, Lee H, Andrews H, Cameron G. Diagnostic criteria for essential tremor?.a population perspective. Arch Neurol 1988;55:823-828.
25. Fahn S, Tolosa E, Marin C. Clinical rating scale for tremor. In: Jankovic J, Tolosa E, editors. Parkinson's disease and movement disorders. London: Butterworth; 1993. p 271-280.
26. Koller WC, Busenbark K, Miner K. The relationship of essential tremor to other movement disorders: report on 678 patients. The Essential Tremor Study Group. Ann Neurol 1994;35:717-723.
27. Deuschl G, Bain. Deep brain stimulation for tremor [correction of trauma]: patient selection and evaluation. Mov Disord. 2002; 17(Suppl. 3):S102-S111.
28. Bain P, Brin M, Deuschl G, et al. Criteria for the diagnosis of essential tremor. Neurology 2000;54(Suppl. 4):S7.
29. Deuschl G. Differential diagnosis of tremor. J Neural Transm Suppl 1999;56:211-220.
30. Elble RJ. Diagnostic criteria for essential tremor and differential diagnosis. Neurology 2000;54(Suppl. 4):S2-S6.
31. Lundervold AD, Pahwa R, Ament AP, Corbin ED. Validity of clinical and patient ratings of tremor disability among older adults. Parkinsonism Relat Disord 2003;10:15-18.
32. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
33. Friso R, Choi S-W, Gireli D, et al. A common mutation in the 5,10-methylenetetra-hydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 2002;99:5606-5611.
34. Louis ED, Zheng W, Jurewicz EC, et al. Elevation of blood β-carboline alkaloids in essential tremor. Neurology 2002; 59:1940-1944.
35. Deuschl G, Elble RJ. The pathophysiology of essential tremor. Neurology 2000;54(Suppl. 4):S14-S20.
36. Jankovic J. Essential tremor: heterogeneous disorder. Mov Disord 2002;17:633-637.