Anti-inflammatory effects of inhaled beclomethasone dipropionate in nonatopic asthmatics

European Respiratory Journal

Volumn 9, Issue 4, 1996, Pages 696-702

  Hoshino, M ^a   Nakamura, Y ^a  

^a TOHO UNIVERSITY   (Japan)

Author keywords

Airway inflammation; beclomethasone dipropionate; monoclonal antibody; nonatopic asthma

Indexed keywords

BECLOMETASONE; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; ASTHMA; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CLINICAL ARTICLE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INFLAMMATION; INFLAMMATORY CELL; MALE; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL;

ADULT; ANTI-ASTHMATIC AGENTS; ASTHMA; BECLOMETHASONE; BIOPSY; BRONCHI; BRONCHIAL PROVOCATION TESTS; CELL COUNT; EOSINOPHILS; FEMALE; HUMANS; LYMPHOCYTE COUNT; MALE; MAST CELLS; MIDDLE AGED; MUCOUS MEMBRANE; NEBULIZERS AND VAPORIZERS; NEUTROPHILS; T-LYMPHOCYTE SUBSETS;

EID: 0029887092     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.96.09040696     Document Type: Article

References (50)

1. Jeffery PK, Wardlaw AJ,Nelson FC, Collins JV, Kay AB. Bronchial biopsies in stable asthma: an ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989; 140: 1745-1753.
2. Djukanovìc R, Wilson JW, Lai CKW, Holgate ST, Howarth PH. The safety aspects of fiberoptic bronchoscopy, bronchoalveolar lavage, and endobronchial biopsy in asthma. Am Rev Respir Dis 1991; 143: 772-777.
3. Beasley R, Roche WR, Roberts JA, Holgate ST. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 1989; 139: 806-817.
4. Walker C, Kaegi MK, Braun P, Blaser K. Activated T-cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. J Allergy Clin Immunol 1991; 88: 935-942.
5. Azzawi M, Bradley B, Jeffery PK, et al. Identification of activated T-lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990; 142: 1407-1413.
6. Li JTC, O'Connell EJ. Viral infections and asthma. Ann Allergy 1987; 59: 321-328.
7. Sventivanyi A. The beta-adrenergic theory of the atopic abnormality in bronchial asthma. J Allergy 1968; 42: 203-232.
8. Turner-Warwick M. Autoantibodies in allergic respiratory diseases. Prog Immunol 1974; 11: 283-292.
9. Pepys J, Hutchcroft BJ. Bronchial provocation tests in etiologic diagnosis and analysis of asthma. Am Rev Respir Dis 1975; 112: 829-859.
10. Bentley AM, Menz G, Storz CHR, et al. Identification of T-lymphocytes, macrophages and activated eosinophils in the bronchial mucosa in intrinsic asthma: relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992; 146: 500-506.
11. 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J Allergy Clin Immnol 1992; 90: 32-42.
12. Dutoit JI, Salome CM, Woolcock AJ. Inhaled corticosteroids reduce the severity of bronchial hyperresponsiveness in asthma but oral theophylline does not. Am Rev Respir Dis 1987; 136: 1174-1178.
13. Walsh SD, Grant IWB. Corticosteroids in treatment of chronic asthma. Br Med J 1966; 2: 796-802.
14. Morrow Brown H, Storey G, George WHS. Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. Br Med J 1972; 1: 585-590.
15. Kerrebijn KF, van Essen-Zandvliet EEM, Neijens HJ. Effect of long-term treatment with inhaled corticosteroid and beta-agonists on the bronchial responsiveness in children with asthma. J Allergy Clin Immunol 1987; 79: 653-659.
16. Juniper EF, Kline PA, Vanzieleghem MA, Ramsdale EH, O'Bryne PM, Hargreave FE. Effect of long-term treatment with an inhaled corticosteroid on airway hyperresponsiveness and clinical asthma in non-steroid-dependent asthmatics. Am Rev Respir Dis 1990; 142: 632-636.
17. Salmeron S, Guerin JC, Godard P, Renon D, Henry-Amar M, Duroux P, Taytard A. High doses of inhaled corticosteroids in unstable chronic asthma: a multicenter, double-blind, placebo-controlled study. Am Rev Respir Dis 1989; 140: 167-171.
18. Heino M, Karjalainen J, Ylikoski J, Laitinen A, Laitinen LA. Bronchial ciliogenesis and oral steroid treatment in patients with asthma. Br J Dis Chest 1988; 82: 175-178.
19. Jeffery PK, Godfrey RW, Ädelroth E, Nelson F, Rogers A, Johansson S-A. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. Am Rev Respir Dis 1992; 145: 890-899.
20. Djukanović R, Wilson JW, Britten KM, et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 1992; 145: 669-674.
21. Lundgren R, Söderberg M, Hörstedt P, Stenling R. Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroid. Eur Respir J 1988; 1: 883-889.
22. Takishima T, Hida W, Sasaki H, Suzuki S, Sasaki T. Directing-writing recorder of the dose-response curves of the airway to methacholine. Chest 1981; 80: 600-606.
23. Bleecke ER. Workshop summary and guidelines: investigative use of bronchoscopy, lavage and bronchial biopsies in asthma and other airways disease. Clin Exp Allergy 1991; 21: 533-539.
24. Nakane PK, Pierce GB. Enzyme-labelled antibodies: preparation and application for localization of antigens. J Histochem Cytochem 1966; 14: 929-931.
25. Shapiro SS, Wilk MB. An analysis of variance test for normality. Biometrika 1965; 52: 591-612.
26. British Thoracic and Tuberculosis Association. A trial of inhaled corticosteroids in patients receiving prednisone. J Dis Chest 1976; 70: 95-103.
27. Svendsen UG, Frolund L, Madsen F, Nielsen NH, Holstein-Rathlou NH, Weeke B. A comparison of the effects of sodium cromoglycate and beclomethasone dipropionate on pulmonary function and bronchial hyperreactivity in subjects with asthma. J Allergy Clin Immunol 1987; 80: 68-74.
28. Tai P-C, Spry CJF, Peterson C, Venge P, Olsson I. Monoclonal antibodies distinguish between storage and secreted forms of eosinophil cationic protein. Nature 1984; 309: 182-184.
29. Gleich GJ, Frigas E, Loegering DA, Wassom DL, Steinmuller D. Cytotoxic properties of the eosinophil major basic protein. J Immunol 1979; 123: 2925-2927.
30. Gundel RH, Letts LG, Gleich GJ. Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates. J Clin Invest 1991; 87: 1470-1473.
31. Motojima S, Frigas E, Loegering DA, Gleich GJ. Toxicity of eosinophil cationic proteins for guinea-pig tracheal epithelium in vivo. Am Rev Respir Dis 1989; 139: 801-805
32. Ädelroth E, Rosenhall L, Johansson S-Å, Linden M, Venge P. Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage: the effects of anti-asthmatic treatment with budesonide or terbutaline. Am Rev Respir Dis 1990; 142: 91-99.
33. Clark PAF, Gallin JI, Fauci AS. Effects of in vivo prednisone on in vitro eosinophil and neutrophil adherence and chemotaxis. Blood 1979; 53: 633-641.
34. Hamid Q, Azzawi M, Sun Ying, et al. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991; 87: 1541-1546.
35. Rolfe FG, Hughes JM, Armour CL, Sewell WA. Inhibition of interleukin-5 gene expression by dexamethasone. Immunology 1992; 77: 494-499.
36. Walls AF, Jones DB, Williams JH, Church MK, Holgate ST. Immunohistochemical identification of mast cells in formaldehyde-fixed tissue using monoclonal antibodies specific for tryptase. J Pathol 1990; 162: 119-126.
37. Djukanović R, Wilson JW, Britten KM, et al. Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immonohistochemistry. Am Rev Respir Dis 1990; 142: 863-871.
38. Bradley BL, Azzawi M, Jacobson M, et al. Eosinophils, T-lymphocytes, mast cells, neutrophils and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin 1991; 88: 661-674.
39. Laitinen LA, Laitinen A, Haahtera T. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Respir Dis 1993; 147: 697-704.
40. Pesci A, Foresi A, Bertorelli G, Chetta A, Oliveri D. Histochemical characteristics and degranulation of mast cells in epithelium and lamina propria of bronchial biopsies from asthmatic and normal subjects. Am Rev Respir Dis 1993; 147: 684-689.
41. Valent P, Spanblöchl E, Sperr WR, et al. Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor/kit-ligand in long-term culture. Blood 1992; 80: 2237-2245.
42. Walker C, Bode E, Boer L, Hansel TT, Blaser K, Virchow JC Jr. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1992; 146: 109-115.
43. Yu DTY, Clements PJ, Paulus HE, Peter JB, Levy J, Barnett EV. Human lymphocyte subpopulations: effect of corticosteroids. J Clin Invest 1974; 53: 565-571.
44. Haynes BF, Fauci AS. The differential effect of in vivo hydrocortisone on the kinetics of subpopulations of human peripheral blood thymus-derived lymphocytes. J Clin Invest 1978; 61: 703-707.
45. Cupps TR, Edgar LC, Thomas CA, Fauci AS. Multiple mechanisms of B-cell immunoregulation in man after administration of in vivo corticosteroids. J Immunol 1984; 132: 170-175.
46. Robinson D, Hamid Q, Sun Ying, et al. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-γ cytokine gene expression. Am Rev Respir Dis 1993; 148: 401-406.
47. Wardlaw AJ, Dunnette S, Gleich GJ, Collins JV, Kay AB. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma: relationship to bronchial reactivity. Am Rev Respir Dis 1988; 137: 62-69.
48. Tanizaki Y, Kitani H, Okazaki M, et al. Changes in bronchoalveolar cell profiles of asthma patients induced by long-term glucocorticoid therapy. Jpn J Thorac Dis 1993; 31: 717-724.
49. Pauwels RA. New aspects of the therapeutic potential of theophylline in asthma. J Allergy Clin Immunol 1989; 83: 548-553.
50. Sullivan P, Bekir S, Jaffar Z, Page C, Jeffery P, Costello J. Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. Lancet 1994; 343: 1006-1008.