Stabilized lipid coated lipoplexes for the delivery of antisense oligonucleotides to liver endothelial cells in vitro and in vivo

Journal of Drug Targeting

Volumn 12, Issue 9-10, 2004, Pages 613-621

  Bartsch, Martin ^a   Weeke Klimp, Alida H ^a   Hoenselaar, Evelien P D ^a   Stuart, Marc C A ^b   Meijer, Dirk K F ^a   Scherphof, Gerrit L ^a   Kamps, Jan A A M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Antisense oligonucleotides; ICAM 1; Long circulating; Non viral vector; PEG stabilized; Targeted delivery

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; HUMAN SERUM ALBUMIN; INTERCELLULAR ADHESION MOLECULE 1; LIPID; LIPOPLEX; MESSENGER RNA; SCAVENGER RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DNA SYNTHESIS; DOWN REGULATION; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DISPOSITION; DRUG FORMULATION; DRUG HALF LIFE; DRUG STABILITY; DRUG TARGETING; ENCAPSULATION; ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CIRCULATION; MACROPHAGE; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; RNA ISOLATION; SUCROSE DENSITY GRADIENT CENTRIFUGATION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ENDOTHELIAL CELLS; HUMANS; LIPOSOMES; LIVER; MALE; OLIGONUCLEOTIDES, ANTISENSE; RATS;

EID: 11944266857     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10611860400013519     Document Type: Article

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