Synthesis and cytotoxic activity of 2-acyl-1H-indole-4,7-diones on human cancer cell lines

European Journal of Medicinal Chemistry

Volumn 40, Issue 1, 2005, Pages 85-92

  Mahboobi, Siavosh ^a   Sellmer, Andreas ^a   Eichhorn, Emerich ^a   Beckers, Thomas ^b   Fiebig, Heinz Herbert ^c   Kelter, Gerhard ^c  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b ALTANA PHARMA AG   (Germany)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

Cell cycle specificity; Cytotoxic activity; Indole 4,7 diones; Tubulin

Indexed keywords

(1 BENZENESULFONYL 1H INDOLE 4,7 DION 2 YL)ONE; (1 BENZENESULFONYL 4,7 DIMETHOXY 1H INDOL 2 YL) (3 FLUOROPHENYL)METHANONE; (1 BENZENESULFONYL 4,7 DIMETHOXY 1H INDOL 2 YL) (3 METHOXYPHENYL)METHANONE; (1 BENZENESULFONYL 4,7 DIMETHOXY 1H INDOL 2 YL) (3,5 DIFLUOROPHENYL) METHANONE; (1 BENZENESULFONYL 4,7 DIMETHOXY 1H INDOL 2 YL)(PENTAFLUOROPHENYL)METHANONE; (1 BENZENESULFONYL 4,7 DIMETHOXY 1H INDOL 2 YL)MORPHOLIN 4 YLMETHANONE; (1 BENZENESULFONYL 4,7 DIMETHOXY 1H INDOL 2 YL)ONE; (1 BENZENESULFONYL 4,7 DIMETHOXY 1H INDOL 2 YL)PHENYLMETHANONE; 1 (1 BENZENESULFONYL 4,7 DIMETHOXY 1H INDOL 2 YL) (4 METHOXYPHENYL) METHANONE; 1 (1 BENZENESULFONYL 4,7 DIMETHOXY 1H INDOL 2 YL)ETHANONE; 1 (1H INDOLE 4,7 DION 2 YL)ONE; 1 BENZENESULFONYL 2 (3 FLUOROBENZOYL) 1H INDOLE 4,7 DIONE; 1 BENZENESULFONYL 2 (3 METHOXYBENZOYL) 1H INDOLE 4,7 DIONE; 1 BENZENESULFONYL 2 (3,5 DIFLUOROBENZOYL) 1H INDOLE 4,7 DIONE; 1 BENZENESULFONYL 2 (4 METHOXYBENZOYL) 1H INDOLE 4,7 DIONE; 1 BENZENESULFONYL 2 (MORPHOLINE 4 CARBONYL) 1H INDOLE 4,7 DIONE; 1 BENZENESULFONYL 2 BENZOYL 1H 4,7 DIONE; 1 BENZENESULFONYL 2 DEUTERO 4,7 DIMETHOXY 1H INDOLE; 1 BENZENESULFONYL 2 PENTAFLUOROBENZOYL 1H INDOLE 4,7 DIONE; 2 (3 FLUOROBENZOYL) 1H INDOLE 4,7 DIONE; 2 (3 METHOXYBENZOYL) 1H 4,7 DIONE; 2 (3,5 DIFLUOROBENZOYL) 1H INDOLE 4,7 DIONE; 2 (4 METHOXYBENZOYL) 1H INDOLE 4,7 DIONE; 2 (5 FLUOROBENZOYL) 1H INDOLE 4,7 DIONE; 2 (MORPHOLINE 4 CARBONYL) 1H INDOLE 4,7 DIONE; 2 ACETYL 1 BENZENESULFONYL 1H INDOLE 4,7 DIONE; 2 ACETYL 1H INDOLE 4,7 DIONE; 2 BENZOYL 1H INDOLE 4,7 DIONE; BENZENESULFONYL 4,7 DIMETHOXY 1H INDOLE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CELL; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CYTOTOXICITY; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOSIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARRIER PROTEINS; CATTLE; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KETONES; KIDNEY NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 11844296080     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.10.007     Document Type: Article

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