Immune reconstitution in HIV-1 infected children with discordant response to antiretroviral therapies: Patterns of HIV-1 ENV gene evolution driven by restoration of thymic function

New Microbiologica

Volumn 27, Issue 2 SUPPL. 1, 2004, Pages 99-104

  Vecchi, M ^a   Burighel, N ^b   Bellanova, D ^b   Menzo, S ^a   De Rossi, A ^b   Clementi, M ^c   Bagnarelli, P ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

env; Evolution; HIV 1; Recocombinant virus; Thymic output; V3

Indexed keywords

ANTIRETROVIRUS AGENT; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120;

CONFERENCE PAPER; ENVELOPE GENE; GENE SEQUENCE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; NONHUMAN; SEQUENCE ANALYSIS; THYMUS;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHILD; DNA, COMPLEMENTARY; EVOLUTION, MOLECULAR; GENES, ENV; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RNA, VIRAL; SELECTION (GENETICS); SEQUENCE ANALYSIS, DNA; T-LYMPHOCYTES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 11844266541     PISSN: 11217138     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (16)

1. BAGNARELLI, P., MAZZOLA, F., MENZO, S., MONTRONI, M., BUTINI, L., CLEMENTI, M. (1999). Host-Specific Modulation Of The Selective Constraints Driving Human Immunodeficiency Virus Type 1 Env Gene Evolution. J. Virol, 73, 3764-3777.
2. BAGNARELLI, P., FIORELLI, L., VECCHI, M., MONACHETTI, A., MENZO, S., CLEMENTI, M. (2003). Analysis of the functional relationship between V3 loop and gp120 context with regard to human immunodeficiency virus coreceptor usage using naturally selected sequences and different viral backbones. Virology, 307, 328-340.
3. CHAVAN, S., BENNURI, B., KHARBANDA, M., CHANDRASEKARAN, A., BAKSHI, S., PAHWA, S. (2001). Evaluation of T cell receptor gene rearrangement excision circles after antiretroviral therapy in children infected with human immunodeficiency virus infection. J Infect Dis, 183, 14451454.
4. COCCHI, F., DE VICO, A.L., GARZINO-DEMO, A., CARA, A., GALLO, R.C., LUSSO, P. (1996). The V3 domain of HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nat Med, 2, 1244-1247.
5. CONNOR, R.I., SHERIDAN, K.E., CERADINI, D., CHOE, S., LANDAU, N.R. (1997). Change in coreceptor use correlates with disease progression in HIV-1-infected individuals. J. Exp Med, 185, 621-628.
6. DE ROSSI, A., WALKER, A.S., KLEIN, N., DE FORNI, D., KING, D., GIBB, D.M. (2002). Increased thymic output after initiation of antiretroviral therapy in human immunodeficiency virus type 1-infected children in the Paediatric European Network for Treatment of AIDS (PENTA) 5 Trial. J Infect Dis, 186, 312-320.
7. JENSEN, M.A. AND VAN'T WOUT A.B. (2003). Predicting HIV-1 Coreceptor Usage with sequence analysis. AIDS Rev, 5, 104-112
8. FROST, S.D., GUNTHARD, H.F., WONG, J.K., HAVLIR, D., RICHMAN, D.D., LEIGH BROWN, A.J. (2001). Evidence for positive selection driving the evolution of HIV-1 env under potent antiviral therapy. Virology, 284, 250-258.
9. MAMMANO, F., TROUPLIN, V., ZENNOU, V., CLAVEL, F (2000). Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug. J Virol, 74, 8524-8531.
10. MENZO, S., MONACHETTI, A., BALOTTA C., CORVASCE, S., RUSCONI, S., PAOLUCCI, S., BALDANTI, F., BAGNARELLI, P., CLEMENTI, M. (2003). Processivity and drug dependance of HIV-1 protease: determinants of viral fitness in variants resistant to protease inhibitors. AIDS, 17, 663-671.
11. OMETTO, L., DE FORNI, D., PATIRI, F., TROUPLIN, V., MAMMANO, F., GIACOMET, V., GIAQUINTO, C., DOUEK, D., KOUP, R., DE ROSSI, A. (2002). Immune reconstitution in HIV-1-infected children on antiretroviral therapy: role of thymic output and viral fitness. AIDS, 16, 839-849.
12. OGERT, R.A., LEE, M.K., ROSS, W., BUCKLER-WHITE, A., MARTIN, M.A., CHO, M.W. (2001). N-Linked glycosylation sites adjacent to and within the V1/V2 and the V3 loops of dualtropic Human Immunodeficiency Virus Type 1 isolate DH12 gp120 affect coreceptor usage and cellular tropism. J Virol, 75, 5998-6006.
13. PHILPOTT, S., WEISER, B., ANASTOS, K., KITCHEN, C.M., ROBISON, E., MEYER W.A. 3RD, SACKS, H.S., MATHUR-WAGH, U., BRUNNER, C., BURGER. H. (2001). Preferential suppression of CXCR4-specific strains of HIV-1 by antiviral therapy. J Clin Invest, 107, 431-438.
14. PILLAI, S., GOOD, B., RICHMAN, D., CORBEIL, J. (2003). A new perspective on V3 phenotype prediction. AIDS Res Hum Retroviruses, 19, 145-149.
15. RESCH, W., HOFFMAN, N., SWANSTROM, R. (2001). Improved success of phenotype prediction of the human immunodeficiency virus type 1 from envelope variable loop 3 sequence using neural networks. Virology, 288, 51-62.
16. STODDART, C.A., LIEGLER, T.J., MAMMANO, F., LINQUIST-STEPPS, V.D., HAYDEN, M.S., DEEKS, S.G., GRANT, R.M., CLAVEL, F., MCCUNE, J.M. (2001). Impaired replication of protease inhibitor-resistant HIV-1 in human thymus. Nat Med, 7, 712-718.