Beneficial effects of a polar fraction of garlic (Allium sativum Linn) oil in rats fed with two different high fat diets

Indian Journal of Experimental Biology

Volumn 43, Issue 1, 2005, Pages 76-83

  Augusti, K T ^a   Chackery, Julie ^a   Jacob, Julie ^a   Kuriakose, Sinu ^a   George, Sharlet ^a   Nair, Sunitha S ^a  

^a MAHATMA GANDHI UNIVERSITY   (India)

Author keywords

Cholesterol; CNO; Garlic oil; Hypocholesterolemic; Hypolipidemic; PFGO; SO

Indexed keywords

BODY FLUIDS; CHOLESTEROL; ENZYMES; LIVING SYSTEMS STUDIES; OILS AND FATS; OXIDATION; TISSUE;

COCONUT OIL (CNO); ENZYME ACTIVITIES; SESAME OIL (SO); TISSUE LIPID;

FOOD PRODUCTS;

ALLYL COMPOUND; ALLYL SULFIDE; COCONUT OIL; GLUTATHIONE REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; SESAME SEED OIL; SULFIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSFERASE; VEGETABLE OIL;

ANIMAL; ARTICLE; ENZYMOLOGY; FAT INTAKE; HEART MUSCLE; HYPERLIPIDEMIA; LIPID METABOLISM; LIVER; METABOLISM; RAT; SPRAGUE DAWLEY RAT;

ALLYL COMPOUNDS; ANIMALS; DIETARY FATS; GLUTATHIONE REDUCTASE; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYPERLIPIDEMIAS; LIPID METABOLISM; LIVER; MYOCARDIUM; PLANT OILS; RATS; RATS, SPRAGUE-DAWLEY; SESAME OIL; SULFIDES; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRANSFERASES;

ALLIUM; ALLIUM SATIVUM; SESAMUM INDICUM;

EID: 11444252738     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Mathew P T & Augusti K T, Studies on the effect of Allicin (diallyl disulphide-oxide) on alloxan diabetes. Part 1-Hypoglycemic action & enhancement of serum insulin effect & glycogen synthesis, Indian J Exp Biol, 10 (1973) 209.
2. Mathew P T & Augusti K T, Isolation of the hypo & hyperglycaemic agents from Allium Cepa Linn, Indian J Exp Biol, 11 (1973) 573.
3. Augusti K T, Gaschromatographic analysis of onion principles & a study on their hypoglycemic action, Indian J Exp Biol, 14 (1976) 110.
4. Block E, The organosulfur chemistry of the Genus Allium-implications for the organic chemistry of sulphur, Angew Chem Int Ed Engl, 31 (1992) 1135.
5. Singh U P, Prithiviraj B, Sharma B K, Singh Mandavi & Ray A B, Role of garlic (Allium sativum L.) in human and plant diseases, Indian J Exp Biol, 39 (2001) 310.
6. Sreekumar P & Kurup P A, Degree of unsaturation of dietary fat & metabolism of lipids on rats fed cholesterol free & cholesterol containing diet, Indian J Exp Biol, 16 (1978) 785.
7. Julie Chackery. Effects of ajoene and two edible oils on the serum lipid and enzymes of rats fed with cholesterol containing diet, M.Sc dessertation submitted to M.G. University Kottayam, India, 2000, 18.
8. Hirose N, Inoue T, Nishihara K, Sugano M, Akimoto K, Shimuzu S & Yamada H, Inhibition of cholesterol absorption and synthesis in rats by sesamin, J Lipid Res, 32 (1991) 629.
9. Augusti K T, Aswathy N, Lekha S P, Razia S E, Reshma S, Sindhu K R, Subha I, Sunitha A & Sunitha S Nair, Beneficial effects of garlic (Allium sativum Linn) on rats fed with diets containing cholesterol and either of the oil seeds, coconuts or ground nuts, Indian J Exp Biol, 39 (2001) 660.
10. Hashim S A, Claney R, Hegstod D M & Stare F J, Effect of mixed fat formula feeding on serum cholesterol level in man, Am J Clin Nutr, 7 (1959) 30.
11. Kaunitz H, Slanetz C A, Johnson R E & Babayan V K, The regulation of depot fat by Linoleic acid, J Nutr, 73 (1961) 386.
12. Vanheck M & Zilversmit D B, Post prandial lipemia and LDL in the rabbit are modified by coconut oil, Atherosclerosis, 10 (1991) 421.
13. Biju C M, Reji S D & Augusti K T, Hypolipidemic effect of garlic protein substituted for casein in the diet of rats compared to those of garlic oil, Indian J Exp Biol, 34 (1996) 337.
14. Chiamori N & Henry R, Total cholesterol, Zlalkis (modified) method, in Gradwohl's clinical laboratory methods and diagnosis, edited by S Frankel, S Reitman and A C Sonnenwirth (The CV Mosby Co, Saint Louis) 1963, 263.
15. Warnic R G & Albers J A, A comprehensive evaluation of the heparin manganese precipitating procedure for estimating high density lipoprotein cholesterol, J Lipid Res, 19 (1978) 65.
16. Van Handel E & Zilversmit D B, Serum triglycerides micromethod, in Gradwohl's clinical laboratory methods and diagnosis, edited by S Frankel, S Reitman and A C Sonnenwirth (The Mosby Co, Saint Louis) 1963, 263.
17. Chowdhary K, Total lipids, biochemical techniques, edition 1 (Jaypee Brothers Medical Publishers, New Delhi) 1989, 113.
18. rd edn, edited by H. Bergmeyer, J Bergmeyer and M Grassl, (Weinheim Verlag Chemie, Basel). 1983, 444.
19. Reitman S & Frankel S, Colorimetric method for aspartate transaminase, in Practical clinical enzymology, edited by J King (D Van Nostrand Company Ltd, London) 1965, 130.
20. Niehaus (Jr) W G & Samuelson B, Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation, Eur J Biochem, 6 (1968) 126.
21. David M & Richard J S. Glutathione reductase, Meth Enzym Analysis 3 (1983) 258.
22. Rao A V & Ramakrishnan S. Indirect assessment of HMGCoA reductase (NADPH) and activity in liver tissue, Clin Chem, 21 (1975) 1523.
23. Sheela C G & Augusti K T, Effects of S-allyl cysteine sulfoxide isolated from Allium sativum Linn and gugulipid on some enzymes and fecal excretions of bile acids and sterols in cholesterol fed rats, Indian J Exp Biol, 33 (1995) 749.
24. Gargouri Y, Moreau H, Jain M K, de Hans G H & Vergerm R, Ajoene prevents fat digestion by human gastric lipase in vitro, Biochem. Biophys Acta, 1006 (1989) 137.
25. Augusti K T, Arathy S L, Asha R, Jaya R, Joseph Z, Lekha V, Smitha S, Sharlet George & Vijayasree V M. A comparative study on the beneficial effects of garlic (A. sativum L) amla (Emblica officinalis Gaertn) and onion (A. cepa L) on the hyperlipidemia induced by butter fat and beef fat in rats, Indian J Exp Biol, 39 (2001) 760.
26. Rajmohan T, Study on the effect of consumption of coconut kernel and coconut oil on the serum lipidprofile, in National seminar on coconut and coconut products in health and disease, edited by M. Aravindakshan (Coconut Development Board, Ministry of Agric. Govt of India, Kochi) 1997, 1.
27. Klanns D A, Sulfur content of free radicals, in Radio protectors and anticarcinogens, edited by O F Nygaard and M G Simic. (Academic Press, New York) 1983, 23.
28. Reuter H D, Koch H P & Lawson L D. Therapeutic effects and applications of garlic and its preparations, in Garlic, The science and therapeutic application of Allium sativum L and related species, edited by H P Koch, L D Lawson (Williams & Wilkins, Baltimore) 1996, 135.
29. Scharfenbery K, Wagner R & Wagner K C, The cytotoxic effect of ajoene, a natural product from garlic investigated with different cell lines, Cancer Lett, 53 (1990)103.
30. Gebhardt R & Beck H, Differential inhibitory effects of garlic derived organosulfides on cholesterol biosynthesis in primary rat hepatocyte cultures, Lipid, 31 (1996) 1269.