Large cell neuroendocrine carcinoma of the lung: A comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma

Lung Cancer

Volumn 47, Issue 2, 2005, Pages 225-233

  Peng, Wei Xia ^a   Sano, Takaaki ^a   Oyama, Tetsunari ^a   Kawashima, Osamu ^b   Nakajima, Takashi ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Shibukawa Medical Center   (Japan)

Author keywords

14 3 3 ; 34 E12; Large cell neuroendocrine carcinoma; LOH at 3p; Neuroendocrine morphology; p16; RB

Indexed keywords

ANTIBODY; MICROSATELLITE DNA; PROTEIN P16;

ADULT; AGED; ARTICLE; CELL CYCLE G2 PHASE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL CARCINOMA; LARGE CELL NEUROENDOCRINE CARCINOMA; LUNG SMALL CELL CANCER; METAPHASE; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; NEUROENDOCRINE TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION;

AGED; ANTIBODIES, NEOPLASM; CARCINOMA, NEUROENDOCRINE; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SMALL CELL; CELL DIFFERENTIATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; RETINOBLASTOMA PROTEIN; RETROSPECTIVE STUDIES;

EID: 11444249658     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2004.06.018     Document Type: Article

References (49)

1. W.D. Travis, R.I. Linnoila, M.G. Tsokos, C.L. Hitchcock, G.B. Cutler, and L. Nieman Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma Am. J. Surg. Pathol. 15 1991 529 553
2. World Health Organization. Histological typing of lung and pleural tumors. 3rd ed. Berlin: Spriner-Verlag; 1999.
3. H. Takei, H. Asamura, A. Maeshima, K. Suzuki, H. Kondo, and T. Niki Large cell neuroendocrine carcinoma of the lung: a clinicopathologic study of 87 cases J. Thorac. Cardiovasc. Surg. 124 2002 285 292
4. A. Iyoda, K. Hiroshima, T. Toyozaki, Y. Haga, T. Fujisawa, and H. Ohwada Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine morphology Cancer 91 2001 1992 2000
5. J. Mazieres, G. Daste, L. Molinier, J. Berjaud, M. Dahan, and M. Delsol Large cell neuroendocrine carcinoma of the lung: pathological study and clinical outcome of 18 resected cases Lung Cancer 37 2002 287 292
6. R.M. Przygodzki, S.D. Finkelstein, J.C. Langer, P.A. Swalsky, N. Fishback, and A. Bakker Analysis of p53, K-ras-2, and C-raf-1 in pulmonary neuroendocrine tumors. Correlation with histological subtype and clinical outcome Am. J. Pathol. 148 1996 1531 1541
7. N. Onuki, I.I. Wistuba, W.D. Travis, A.K. Virmani, K. Yashima, and E. Brambilla Genetic changes in the spectrum of neuroendocrine lung tumors Cancer 85 1999 600 607
8. R. Ullmann, A. Schwendel, H. Klemen, G. Wolf, I. Petersen, and H.H. Popper Unbalanced chromosomal aberrations in neuroendocrine lung tumors as detected by comparative genomic hybridization Hum. Pathol. 29 1998 1145 1149
9. J. Zacharias, A.G. Nicholson, G.P. Ladas, and P. Goldstraw Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung prognosis after complete resection and systematic nodal dissection Ann. Thorac. Surg. 75 2003 348 352
10. S.X. Jiang, T. Kameya, M. Shoji, Y. Dobashi, J. Shinada, and H. Yoshimura Large cell neuroendocrine carcinoma of the lung: a histologic and immunohistochemical study of 22 cases Am. J. Surg. Pathol. 22 1998 526 537
11. M. Harada, T. Yokose, J. Yoshida, Y. Nishiwaki, and K. Nagai Immunohistochemical neuroendocrine differentiation is an independent prognostic factor in surgically resected large cell carcinoma of the lung Lung Cancer 38 2002 177 184
12. M.J. Kelley, K. Nakagawa, S.M. Steinberg, J.L. Mulshine, A. Kamb, and B.E. Johnson Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines J. Natl. Cancer Inst. 87 1995 756 761
13. M. Gugger, E. Burckhardt, A. Kappeler, H. Hirsiger, J.A. Laissue, and L. Mazzucchelli Quantitative expansion of structural genomic alterations in the spectrum of neuroendocrine lung carcinomas J. Pathol. 196 2002 408 415
14. D.A. Hirotoshi, P.T. Cagle, H. Hiroumi, M. Fujita, M. Yamashita, and A. Sharma Differential retinoblastoma and p16INK4A protein expression in neuroendocrine tumors of the lung Cancer 88 2000 550 556
15. J. Yuan, J. Knorr, M. Altmannsberger, G. Goeckenjan, A. Scharl, and K. Strebhardt Expression of p16 and lack of pRB in primary small cell lung cancer J. Pathol. 189 1999 358 362
16. R.A. Kratzke, T.M. Greatens, J.B. Rubins, M.A. Maddaus, D.E. Niewoehner, and G.A. Niehans Rb and p16INK4a expression in resected non-small cell lung tumors Cancer Res. 56 1996 3415 3420
17. M. Sakaguchi, Y. Fujii, H. Hirabayashi, H.E. Yoon, Y. Komoto, and T. Oue Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: an immunohistochemical study Int. J. Cancer 65 1996 442 445
18. H. Tanaka, Y. Fujii, H. Hirabayashi, S. Miyoshi, M. Sakaguchi, and H.E. Yoon Disruption of the RB pathway and cell-proliferative activity in non-small-cell lung cancers Int. J. Cancer 79 1998 111 115
19. K. Kashiwabara, T. Oyama, T. Sano, T. Fukuda, and T. Nakajima Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and Rb proteins in primary non-small cell lung cancers Int. J. Cancer 79 1998 215 220
20. S. Gazzeri, V. Gouyer, C. Vour'ch, C. Brambilla, and E. Brambilla Mechanisms of p16INK4A inactivation in non small-cell lung cancers Oncogene 16 1998 497 504
21. H. Osada, Y. Tatematsu, Y. Yatabe, T. Nakagawa, H. Konishi, and T. Harano Frequent and histological type-specific inactivation of 14-3-3σ in human lung cancers Oncogene 21 2002 2418 2424
22. Y. Yatabe, H. Osada, Y. Tatematsu, T. Mitsudomi, and T. Takahasi Decreased expression of 14-3-3σ in neuroendocrine tumors is independent of origin and malignant potential Oncogene 21 2002 8310 8319
23. C.B. Umbricht, E. Evron, E. Gabrielson, A. Ferguson, J. Marks, and S. Sukumar Hypermethylation of 14-3-3σ (stratifin) is an early event in breast cancer Oncogene 20 2001 3348 3353
24. A.T. Ferguson, E. Evron, C.B. Umbricht, T.K. Pandita, T.A. Chan, and H. Hermeking High frequency of hypermethylation at the 14-3-3σ locus leads to gene silencing in breast cancer Proc. Natl. Acad. Sci. U.S.A. 97 2000 6049 6054
25. T. Nakajima, H. Shimooka, W.X. Peng, A. Segawa, A. Motegi, and J. Zhang Immunohistochemical demonstration of 14-3-3σ protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage Pathol. Int. 53 2003 353 360
26. Ide M, Nakajima T, Asao T, Kuwano H. Inactivation of 14-3-3σ by hypermethylation is a rare event in colorectal cancers and its expression may correlate with cell cycle maintenance at the invasion front. Cancer Lett [in press].
27. H. Hermeking, C. Lengauer, K. Polyak, T.C. He, L. Zhang, and S. Thiagalingam 14-3-3σ is a p53-regulated inhibition of G2/M progression Mol. Cell. 1 1997 3 11
28. T. Takahashi, M.M. Nau, I. Chiba, M.J. Birrer, R.K. Rosenberg, and M. Vinocour p53: a frequent target for genetic abnormalities in lung cancer Science 246 1989 491 494
29. D. D'Amico, D. Carbone, T. Mitsudomi, M. Nau, J. Fedorko, and E. Russell High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors Oncogene 7 1992 339 346
30. K.M. Fong, Y. Kida, P.V. Zimmerman, M. Ikenaga, and P.J. Smith Loss of heterozygosity frequently affects chromosome 17q in non-small cell lung cancer Cancer Res. 55 1995 4268 4272
31. Q. Xue, T. Sano, K. Kashiwabara, T. Oyama, and T. Nakajima Aberrant expression of pRb, p16, p14ARF, MDM2, p21 and p53 in squamous cell carcinomas of lung Jpn. J. Cancer Res. 92 2001 285 292
32. N. Sturm, G. Rossi, S. Lantuéjoul, M.H. Laverrière, M. Papotti, and P.Y. Brichon 34E12 expression along the whole spectrum of neuroendocrine proliferations of the lung, from neuroendocrine cell hyperplasia to small cell carcinoma Histopathology 42 2003 156 166
33. N. Sturm, S. Lantuéjoul, M.H. Laverrière, M. Papotti, P.Y. Brichon, and C. Brambilla Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (34 β E12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung Hum. Pathol. 32 2001 918 925
34. J. Zamecnik, and R. Kodet Value of thyroid transcription factor-1 and surfacntant apoprotein A in the differential diagnosis of pulmonary carcinomas: a study of 109 cases Virchows Arch. 440 2002 353 361
35. L. Zhang, J.A. Whitsett, and B.R. Stripp Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1 Biochim. Biophys. Acta. 1350 1997 359 367
36. R.J. Bohinski, R. Di Lauro, and J.A. Whitsett The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis Mol. Cell. Biol. 14 1994 5671 5681
37. N. Strum, G. Rossi, S. Lantuejoul, M. Papotti, S. Frachon, and C. Claraz Expression of thyroid transcription factor-1 in the spectrum of neuroendocrine cell lung proliferations with special interest in carcinoids Hum. Pathol. 33 2002 175 182
38. G. Rossi, A. Cavazza, A. Marchioni, M. Migaldi, M. Bavieri, and N. Facciolongo Kit expression in small cell carcinomas of the lung: effects of chemotherapy Mod. Pathol. 16 2003 1041 1047
39. K. Araki, G. Ishii, T. Yokose, K. Nagai, K. Funai, and K. Kodama Frequent overexpression of the c-kit protein in large cell neuroendocrine carcinoma of the lung Lung Cancer. 40 2003 173 180
40. P. Micke, M. Basrai, A. Faldum, F. Bittinger, L. Ronnstrand, and A. Blaukat Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications Clin. Cancer Res. 9 2003 188 194
41. G.W. Krystal, S. Honsawek, J. Litz, and E. Buchdunger The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth Clin. Cancer Res. 6 2000 3319 3326
42. E.R. Zabarovsky, M.I. Lerman, and J. Minna Tumor supressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers Oncogene 21 2002 6915 6935
43. I.I. Wistuba, J. Berry, C. Behrens, A. Maitra, N. Shivapurkar, and S. Milchgrub Molecular changes in the bronchial epithelium of patients with small cell lung cancer Clin. Cancer Res. 6 2000 2604 2610
44. E. Braga, E. Pugacheva, I. Bazov, V. Ermilova, T. Kazubskaya, and N. Mazurenko Comparative allelotyping of the short arm of human chromosome 3 in epithelial tumors of four different types FEBS Lett. 454 1999 215 219
45. R. Ullmann, S. Petzmann, A. Sharma, P.T. Cagle, and H.H. Popper Chromosomal aberrations in a series of large-cell neuroendocrine carcinomas: unexpected divergence from small-cell carcinoma of the lung Hum. Pathol. 32 2001 1059 1063
46. L. Girard, S. Zochbauer-Muller, A.K. Virmani, A.F. Gazdar, and J.D. Minna Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering Cancer Res. 60 2000 4894 4906
47. K. Kok, S.L. Naylor, and C.H. Buys Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes Adv. Cancer Res. 71 1997 27 92
48. K. Lindblad-Toh, D.M. Tanenbaum, M.J. Daly, E. Winchester, W.O. Lui, and A. Villapakkam Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays Nat. Biotechnol. 18 2000 1001 1005
49. Y. Tomizawa, T. Nakajima, T. Kohno, R. Saito, N. Yamaguchi, and J. Yokota Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma Cancer Res. 58 1998 5478 5483