Emphysema: The challenge of the remodelled lung

Journal of Pathology

Volumn 202, Issue 2, 2004, Pages 141-144

  Blundell, R ^a,b   Harrison, D J ^a   Wallace, William A H ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF MALTA   (Malta)

Author keywords

Emphysema; Gene therapy; Molecular biology; Pathology

Indexed keywords

ALPHA 1 ANTITRYPSIN; CYTOCHROME P450 1A1; EPOXIDE HYDROLASE; GLUTATHIONE TRANSFERASE; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; PROTEINASE;

AIRWAY OBSTRUCTION; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; DISEASE COURSE; DISEASE PREDISPOSITION; EMPHYSEMA; GENE THERAPY; GENETIC SUSCEPTIBILITY; HUMAN; MORPHOLOGY; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN FUNCTION; SMOKING CESSATION;

GENE THERAPY; HUMANS; OXIDATIVE STRESS; PULMONARY EMPHYSEMA;

EID: 1142311550     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1500     Document Type: Article

References (40)

1. Strachan DP. Epidermology: a British perspective. In Chronic Obstructive Pulmonary Disease, Calverley P, Pride N (eds). Chapman & Hall: London, 1995; 47-68.
2. MacNee W, Gould G, Lamb D. Quantifying emphysema by CT scanning: clinicopathological correlates. Annu N Y Acad Sci 1991; 624: 179-194.
3. Lamb D, McLean A, Gillooley M, Warren PM, Gould GA, Macnee W. Relation between distal airspace size, bronchiolar attachments and lung function. Thorax 1993; 48: 1012-1017.
4. Nagai A, Yamawaki I, Takizana T, Thurlbeck WM. Alveolar attachments in emphysema of human lungs. Am Rev Respir Dis 1991; 144: 888-891.
5. Ciba Foundation Guest Symposium. Terminology, definitions and classification of chronic pulmonary emphysema and related conditions. Thorax 1959; 14: 286-299.
6. American Thoracic Society. Chronic bronchitis, asthma and pulmonary emphysema. Am Rev Respir Dis 1962; 85: 762-768.
7. Snider GL, Kleinerman J, Thurlbeck WM. The definition of emphysema. Am Rev Respir 1985; 132: 182-185.
8. Lamb D. Pathology. In Chronic Obstructive Pulmonary Disease, Calverley P, Pride N (eds). Chapman & Hall: London, 1995; 9-34.
9. Gillooly M, Lamb D. Airspace size in lungs of lifelong non-smokers: effects of age and sex. Thorax 1993; 48: 39-43.
10. Lang MR, Fiaux GW, Gillooly M, Stewart JA, Hulmes DJ, Lamb D. Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs. Thorax 1994; 49: 319-326.
11. Lamb D. Chronic bronchitis, emphysema and the pathological basis of chronic obstructive pulmonary disease. In Spencer's Pathology of the Lung (5th edn), Hasleton PS (ed). McGraw-Hill: New York; 1996; 597-630.
12. Thurlbeck WM. The pathobiology and epidemiology of human emphysema. J Toxicol Environ Health 1984; 13: 323-343.
13. Nagai A, West WW, Thurlbeck WM. The National Institutes of Health Intermittent Positive-Pressure Breathing trial: pathology studies. II. Correlation between morphologic findings, clinical findings, and evidence of expiratory air-flow obstruction. Am Rev Respir Dis 1985; 132: 946-953.
14. Gadeu JE, Pacht ER. The protease/antiprotease balance within the human lung: implications for the pathogenesis of emphysema. Lung 1990; 168: 552-564.
15. Rudolphus A, Kramps JA, Mauve I, Dijkman JH. Intratracheally-instilled antileukoprotease and alpha-1-proteinase inhibitor: effect on human neutrophil elastase-induced experimental emphysema and pulmonary localization. J Histochem 1994; 26: 817-824.
16. Chow CK. Cigarette smoking and oxidative damage in the lung. Ann N Y Acad Sci 1993; 686: 289-298.
17. Fujita J, Nelson NL, Daughton DM, et al. Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema. Am Rev Respir Dis 1990; 142: 57-62.
18. King MB, Campbell EJ, Gray BH, Hertz MI. The proteinase-antiproteinase balance in alpha-1 proteinase inhibitor-deficient lung transplant recipients. Am J Respir Crit Care Med 1994; 151: 966-971.
19. Travis J, Pike R, Imamura T, Potempa J. The role of proteolytic enzymes in the development of pulmonary emphysema and periodental tissue. Am J Respir Crit Care Med 1995; 151: 925-929.
20. Wallace WAH, Gillooley M, Lamb D. Intra-alveolar macrophage numbers in current smokers and non-smokers: a morphometric study of tissue sections. Thorax 1992; 47: 437-440.
21. Tetley TD. Macrophages and the pathogenesis of COPD. Chest 2002; 121: (5 Suppl): 156S-159S.
22. Church DF, Pryor WA. Free radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985; 64: 111-126.
23. Hoffman D, Hecht SS. Advances in tobacco carcinogenesis. Handbook Exp Pharmacol 1990; 94: 63-102.
24. Smith CAD, Smith G, Wolf CR. Genetic predisposition to cancer: polymorphisms in xenobiotic metabolising enzymes. Eur J Cancer 1994; 30A: 1921-1936.
25. Rahman I, MacNee W. Role of oxidant/antioxidant in smoking induced lung diseases. Free Radical Biol Med 1996; 21: 669-689.
26. Aoshiba K, Nagai A, Konno K. Nicotine prevents a reduction in neutrophil filterability induced by cigarette smoke exposure. Am J Respir Crit Care Med 1994; 150: 1101-1107.
27. Choi AM, Alam J. Heme oxygenase-1: function, regulation and implication of a novel stress-induced protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 1996; 15: 9-19.
28. McLemore TL, Adelberg S, Liu MC, et al. Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in primary pulmonary carcinomas. J Natl Cancer Inst 1990; 82: 1333-1339.
29. Cantlay AM, Lamb D, Gillooley M, et al. Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer. JCP - Clin Mol Pathol 1995; 48: M210-M214.
30. Nakajima T, Elovaara E, Anttila S, et al. Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer. Carcinogenesis 1995; 16: 707-711.
31. Harrison DJ, Cantlay AM, Rae F, Lamb D, Smith CA. Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer. Hum Exp Toxicol 1997; 16: 356-360.
32. Buhl R, Meyer A, Vogelmeier C. Oxidant-protease interaction in the lung. Prospects for antioxidant therapy. Chest 1996; 110: 267-272.
33. Smith CAD, Harrison DJ. Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema. Lancet 1997; 350: 630-634.
34. Seth JM, Rochester CL. Smoking and chronic obstructive pulmonary disease. Clin Chest Med 2000; 21: 67-86.
35. Lucey EC, Goldstein RH, Stone PJ, Snider GL. Remodeling of alveolar wall after elastase treatment of hamsters. Results of elastin and collagen mRNA in situ hybridization. Am J Respir Crit Care Med 1998; 158: 555-564.
36. Massaro GD, Massaro D. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nature Med 1997; 3: 675-677.
37. Morris SM, Thomas KM, Rich CB, Stone PJ. Degradation and repair of elastic fibres in rat lung interstitial fibroblast cultures. Anat Rec 1998; 250: 397-407.
38. Shinguh Y, Yamazaki A, Inamura N, et al. Biochemical and pharmacological characterization of FR134043, a novel elastase inhibitor. Eur J Pharmacol 1998; 345: 299-308.
39. Wilcke JT, Dirksen A. The effect of inhaled glucocorticosteroids in emphysema due to alpha 1-antitrypsin deficiency. Respir Med 1997; 91: 275-279.
40. McBride S, Rannie D, Harrison DJ. Gene transfer to adult human lung tissue ex vivo. Gene Ther 2000; 7: 675-678.