Biochemical and pharmacological characterization of FR134043, a novel elastase inhibitor

European Journal of Pharmacology

Volumn 345, Issue 3, 1998, Pages 299-308

  Shinguh, Yasuhiko ^a   Yamazaki, Akiko ^a   Inamura, Noriaki ^a   Fujie, Keiko ^a   Okamoto, Masanori ^a   Nakahara, Kunio ^a   Notsu, Yoshitada ^a   Okuhara, Masakuni ^a   Ono, Takaharu ^a  

^a Exploratory Research Laboratories   (Japan)

Author keywords

Adult respiratory distress syndrome; Disseminated intravascular coagulation; Edema; Elastase; Elastase inhibitor; FR134043; Hemorrhage; Pulmonary emphysema; Septic shock

Indexed keywords

ALPHA 1 ANTITRYPSIN; CHYMOTRYPSIN A; ELASTASE INHIBITOR; ELASTIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FIBRIN DEGRADATION PRODUCT; FIBRINOGEN; FR 134043; FR 901277; LACTONE; LEUKOCYTE ELASTASE; PANCREATIC ELASTASE; PROTHROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATTLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG STRUCTURE; FEMALE; HAMSTER; HUMAN; HUMAN CELL; INTRATRACHEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; LUNG EMPHYSEMA; LUNG HEMORRHAGE; MALE; MOUSE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PAW EDEMA; PHARMACOLOGY; PRIORITY JOURNAL; PROTHROMBIN TIME; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; SWINE; THROMBOCYTOPENIA;

ANIMALS; CATTLE; CRICETINAE; DISSEMINATED INTRAVASCULAR COAGULATION; EDEMA; EMPHYSEMA; FEMALE; HEMORRHAGE; HETEROCYCLIC COMPOUNDS; HUMANS; INDICATORS AND REAGENTS; LEUKOCYTE ELASTASE; MICE; NEUTROPHILS; PANCREATIC ELASTASE; SERINE PROTEINASE INHIBITORS; SWINE;

EID: 0032568249     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00028-4     Document Type: Article

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