Mutations in calcium-binding epidermal growth factor modules render fibrillin-1 susceptible to proteolysis. A potential disease-causing mechanism in Marfan syndrome

Journal of Biological Chemistry

Volumn 275, Issue 16, 2000, Pages 12339-12345

  Reinhardt, Dieter P ^a   Ono, Robert N ^b   Notbohm, Holger ^a   Müller, Peter K ^a   Bächinger, Hans Peter ^b   Sakai, Lynn Y ^b  

^a UNIVERSITY OF LÜBECK   (Germany)

^b SHRINERS HOSPITAL FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; FIBRILLIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM BINDING; CIRCULAR DICHROISM; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE MUTATION; MAMMAL CELL; MARFAN SYNDROME; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; CALCIUM; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPIDERMAL GROWTH FACTOR; HUMANS; MARFAN SYNDROME; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; MAMMALIA;

EID: 0034697304     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.16.12339     Document Type: Article

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