Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro

Asia Pacific Journal of Clinical Nutrition

Volumn 13, Issue 4, 2004, Pages 401-408

  McCue, Patrick ^a   Vattem, Dhiraj ^a   Shetty, Kalidas ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Amylase inhibitors; Diabetes mellitus; Herbal extracts; Hyperglycemia; Obesity; Oregano; Rosmarinic acid

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; AMYLASE; AMYLASE INHIBITOR; ORIGANUM VULGARE EXTRACT; PARA COUMARIC ACID; PHENOL DERIVATIVE; PLANT EXTRACT; PORCINE PANCREATIC AMYLASE; PROTOCHATECHUIC ACID; QUERCETIN; ROSMARINIC ACID; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR CLONING; OREGANO;

AMYLASES; ANIMALS; ANTIOXIDANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNAMATES; CLONING, MOLECULAR; COUMARIC ACIDS; DEPSIDES; HYDROXYBENZOIC ACIDS; HYPOGLYCEMIC AGENTS; MODELS, ANIMAL; ORIGANUM; PANCREAS; PLANT EXTRACTS; QUERCETIN; SEEDS; SWINE;

ORIGANUM; ORIGANUM VULGARE; SUIDAE;

EID: 11244344838     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813-820.
2. Haffner SM. The importance of hyperglycemia in the non-fasting state to the development of cardiovascular disease. Endocrine Rev 1998; 19 (5): 583-592.
3. Haller H. The clinical importance of postprandial glucose. Diabetes Res Clin Pract 1998; 40: S43-S49.
4. Mudaliar S, Henry RR. New oral therapies for type 2 diabetes mellitus: the glitazones or insulin sensitizers. Annu Rev Med 2001; 52: 239-257.
5. Costacou T, Mayer-Davis EJ. Nutrition and prevention of type 2 diabetes. Annu Rev Nutr 2003; 23: 147-170.
6. Ohmura C, Tanaka Y, Mitsuhashi N, Atsum Y, Matsuoka K, Onuma T, Kawamori R. Efficacy of low-dose metformin in Japanese patients with type 2 diabetes mellitus. Curr Ther Res 1998; 59 (12): 889-895.
7. Chen H, Feng R, Guo Y, Sun L, Jiang J. Hypoglycemic effects of aqueous extract of Rhizoma Polygonati Odorati in mice and rats. J Ethnopharm 2001; 74: 225-229.
8. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharm 2002; 81: 81-100.
9. Yang R, Shetty K. Stimulation of rosmarinic acid in shoot cultures of oregano (Origanum vulgare) clonal line in response to proline, proline analogue, and proline precursors. J Agric Food Chem 1998; 46 (7): 2888-2893.
10. McCue P, Shetty K. Inhibitory effects of rosmarinic acid extracts on porcine pancreatic amylase in vitro. Asia Pac Clin Nutr 2004; 13(1): 101-106.
11. Eguchi Y, Curtis OF, Shetty K. Interaction of hyperhydricity-preventing Pseudomonas sp. with oregano (Origanum vulgare) and selection of high phenolics and rosmarinic acid-producing clonal lines. Food Biotechnol 1996; 10(3): 191-202.
12. Shetty K, Curtis OF, Levin RE, Witkowski R, Ang W. Prevention of vitrification associated with in vitro shoot culture or oregano (Origanum vulgare) by Pseudomonas spp. J Plant Physiol 1995; 147: 447-451.
13. McCue P, Shetty K. Clonal herbal extracts as elicitors of phenolic synthesis in dark-germinated mungbean for improving nutritional value with implications for food safety. J Food Biochem 2002; 26: 209-232.
14. Correia RTP, McCue P, Vattem DA, Magalhães MMA, Macêdo GR, Shetty K. Amylase and Helicobacter pylori inhibition by phenolic extracts of pineapple wastes bioprocessed by Rhizopus oligosporus. J Food Biochem 2004; In press.
15. McCue P, Horii A, Shetty, K. Solid-state bioconversion of phenolic antioxidants from defatted soybean powders by Rhizopus oligosporus: role of carbohydrate-cleaving enzymes. J Food Biochem 2003; 27 (6): 501-514.
16. Sayle RA, Milner-White EJ. RASMOL: biomolecular graphics for all. Trends Biochem Sci 1995; 20(9): 374-376.
17. Bernstein HJ. Recent changes to RasMol, recombining the variants. Trends Biochem Sci 2000; 25 (9): 453-455.
18. Bompard-Gilles C, Rousseau P, Rougé P, Payan F. Substrate mimicry in the active center of a mammalian □ - amylase: structural analysis of an enzyme-inhibitor complex. Structure 1996; 4: 1441-1452.