Synthesis and cytotoxic activity of thiazolofluorenone derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 19, Issue 6, 2004, Pages 567-575

  Chabane, Hadjila ^a,b   Pierre, Alain ^c   Leonce, Stephane ^c   Pfeiffer, Bruno ^c   Renard, Pierre ^c   Thiery, Valerie ^a   Guillaumet, Gerald ^b   Besson, Thierry ^a  

^a UNIVERSITÉ DE LA ROCHELLE   (France)

^b UNIVERSITÉ D'ORLÉANS   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Cytotoxic activity; Fluorenones; Imino 1,2,3 dithiazoles; Thiazoles

Indexed keywords

(3 BROMO 9H FLUOREN 2 YL)(4 CHLORO[1,2,3]DITHIAZOL 5 YLIDENE)AMINE; (4 CHLORO [1,2,3]DITHIAZOL 5 YLIDENE)(9H FLUOREN 2 YL)AMINE; 10 OXO 10H [1,3]THIAZOLOCYCLOPENTA[A]FLUORENE 2 CARBONITRILE; 2 (1H BENZIMIDAZOL 2 YL)[3,1]THIAZOLOCYCLOPENTA[B]FLUOREN 9 ONE; 2 (4 CHLORO [1,2,3]DITHIAZOL 5 YLIDENEAMINO)FLUOREN 9 ONE; 2 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 9H [3,1]THIAZOLOCYCLOPENTA[B]FLUORENE; 2 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)[1,3]THIAZOLOCYCLOPENTA[A]FLUOREN 10 ONE; 2 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)[1,3]THIAZOLOCYCLOPENTA[B]FLUOREN 9 ONE; 2 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)[3,1]THIAZOLOCYCLOPENTA[B]FLUOREN 9 ONE; 2 (4,5 DIHYDRO 1H IMIDAZOLYL)ANTHRA[2,1 D]THIAZOLE 6,11 DIONE; 2 [1 (2 DIETHYLAMINOETHYL) 4.5 DIHYDRO 1H IMIDAZOLE][3,1]THIAZOLOCYCLOPENTA[B]FLUOREN 9 ONE; 3 (4 CHLORO [1,2,3]DITHIAZOL 5 YLIDENEAMINO)FLUOREN 9 ONE; 3 BROMO 9H FLUORENE 2 YLAMINE; 4 CHLORO ([1,2,3]DITHIAZOL 5 YLIDENEAMINO)ANTHRAQUINONE; 6,11 DIOXO 6,11 DIHYDROANTHRA[2,1 D]THIAZOLE 2 CARBONITRILE; 9 OXO 9H [1,3]THIAZOLOCYCLOPENTA[B]FLUORENE 2 CARBONITRILE; 9 OXO 9H [3,1]THIAZOLOCYCLOPENTA[B]FLUORENE 2 CARBOXIMIDIC ACID 2 DIMETHYLAMINO ETHYL ESTER; 9 OXO 9H [3,1]THIAZOLOCYCLOPENTA[B]FLUORENE 2 CARBOXIMIDIC ACID ETHYL ESTER; 9 OXO 9H [3.1]THIAZOLOCYCLOPENTA[B]FLUORENE 2 CARBONITRILE; 9H [3,1]THIAZOLOCYCLOPENTA[B]FLUORENE 2 CARBONITRILE; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; FLUORENE DERIVATIVE; N (2 DIMETHYLAMINOETHYL) 9 OXO 9H [3,1]THIAZOLOCYCLOPENTA[B]FLUORENE 2 CARBOXAMIDINE; N HYDROXY 9 OXO 9H [3.1]THIAZOLOCYCLOPENTA[B]FLUORENE 2 CARBOXAMIDINE; THIAZOLE DERIVATIVE; THIAZOLOFLUORENONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROSCOPY; LEUKEMIA CELL LINE; METAPHASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY;

ANIMALS; ANTHRAQUINONES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORENES; LEUKEMIA L1210; MICE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 11244291119     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756360400004607     Document Type: Article

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