Enhanced interleukin-18 levels in the peripheral blood of children with coeliac disease

Clinical and Experimental Immunology

Volumn 139, Issue 1, 2005, Pages 138-143

  Lettesjö, Helene ^a   Hansson, T ^a,b   Bergqvist, A ^a   Gronlund J ^c   Dannaeus, A ^d  

^a Thermo Fisher Scientific   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

^d UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Coeliac; Cytokines; Disease; IL 18

Indexed keywords

GLUTEN; IMMUNOGLOBULIN A ANTIBODY; INTERLEUKIN 18; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

ADOLESCENT; ARTICLE; BLOOD LEVEL; CELIAC DISEASE; CELL HYPERPLASIA; CHILD; CONTROLLED STUDY; CRYPT CELL; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE MARKER; ENTERITIS; EXPOSURE; FEMALE; GASTROINTESTINAL DISEASE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INTESTINE VILLUS ATROPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SMALL INTESTINE DISEASE; TH1 CELL;

ADOLESCENT; ATROPHY; BIOLOGICAL MARKERS; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; DIET, PROTEIN-RESTRICTED; FEMALE; GLUTEN; HUMANS; IMMUNOGLOBULIN A; INFANT; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-18; INTESTINE, SMALL; MALE; RETROSPECTIVE STUDIES; TRANSGLUTAMINASES;

EID: 11244285058     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02661.x     Document Type: Article

References (37)

1. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002; 2:647-55.
2. Molberg Ø, McAdam SN, Körner R et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 1998; 41:713-7.
3. van de Wal Y, Kooy Y, van Veelen P et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 1998; 161:1585-8.
4. Dieterich W, Laag E, Schopper H et al. Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology 1998; 115:1317-21.
5. Bürgin-Wolff A, Dahlbom I, Hadziselimovic F, Petersson CJ. Antibodies against human tissue transglutaminase and endomysium in diagnosing and monitoring coeliac disease. Scand J Gastroenterol 2002; 37:685-91.
6. Mäki M, Mustalahti K, Kokkonen J et al. Prevalence of celiac disease among children in Finland. N Engl J Med 2003; 348:2517-24.
7. MacDonald TT, Bajaj-Elliott M, Pender SL. T cells orchestrate intestinal mucosal shape and integrity. Immunol Today 1999; 20:505-10.
8. Nilsen EM, Jahnsen FL, Lundin KE et al. Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. Gastroenterology 1998; 115:551-63.
9. Nilsen EM, Lundin KE, Krajci P, Scott H, Sollid LM, Brandtzaeg P. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut 1995; 37:766-76.
10. Westerholm-Ormio M, Garioch J, Ketola I, Savilahti E. Inflammatory cytokines in small intestinal mucosa of patients with potential coeliac disease. Clin Exp Immunol 2002; 128:94-101.
11. Kontakou M, Przemioslo RT, Sturgess RP, Limb AG, Ciclitira PJ. Expression of tumour necrosis factor-alpha, interleukin-6, and interleukin-2 mRNA in the jejunum of patients with coeliac disease. Scand J Gastroenterol 1995; 30:456-63.
12. Przemioslo RT, Kontakou M, Nobili V, Ciclitira PJ. Raised proinflammatory cytokines interleukin 6 and tumour necrosis factor alpha in coeliac disease mucosa detected by immunohistochemistry. Gut 1994; 35:1398-403.
13. Kontakou M, Sturgess RP, Przemioslo RT, Limb GA, Nelufer JM, Ciclitira PJ. Detection of interferon gamma mRNA in the mucosa of patients with coeliac disease by in situ hybridisation. Gut 1994; 35:1037-41.
14. Hansson T, Ulfgren AK, Lindroos E, Dannaeus A, Dahlbom I, Klareskog L. Transforming growth factor-beta (TGF-beta) and tissue transglutaminase expression in the small intestine in children with coeliac disease. Scand J Immunol 2002; 56:530-7.
15. Okamura H, Kashiwamura S, Tsutsui H, Yoshimoto T, Nakanishi K. Regulation of interferon-gamma production by IL-12 and IL-18. Curr Opin Immunol 1998; 10:259-64.
16. Dinarello CA. IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol 1999; 103:11-24.
17. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 2001; 19:423-74.
18. Pizarro TT, Michie MH, Bentz M et al. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol 1999; 162:6829-35.
19. Monteleone G, Trapasso F, Parrello T et al. Bioactive IL-18 expression is up-regulated in Crohn's disease. J Immunol 1999; 163:143-7.
20. Kanai T, Watanabe M, Okazawa A et al. Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease. Gastroenterology 2000; 119:1514-23.
21. Salvati VM, MacDonald TT, Bajaj-Elliott M et al. Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease. Gut 2002; 50:186-90.
22. Merendino RA, Di Pasquale G, Sturniolo GC et al. Relationship between IL-18 and sICAM-1 serum levels in patients affected by coeliac disease: preliminary considerations. Immunol Lett 2003; 85:257-60.
23. Tursi A, Brandimarte G, Giorgetti GM. Prevalence of antitissue transglutaminase antibodies in different degrees of intestinal damage in celiac disease. J Clin Gastroenterol 2003; 36:219-21.
24. Hansson T, Dahlbom I, Rogberg S et al. Recombinant human tissue transglutaminase for diagnosis and follow-up of childhood coeliac disease. Pediatr Res 2002; 51:700-5.
25. Collin P, Helin H, Mäki M, Hallström O, Karvonen AL. Follow-up of patients positive in reticulin and gliadin antibody tests with normal small-bowel biopsy findings. Scand J Gastroenterol 1993; 28:595-8.
26. Meeuwisse GW. Diagnostic criteria in coeliac disease. Acta Paediatr Scand 1970; 59:461-3.
27. Hansson T, Dannaeus A, Kraaz W, Sjöberg O, Klareskog L. Production of antibodies to gliadin by peripheral blood lymphocytes in children with celiac disease: the use of an enzyme-linked immunospot technique for screening and follow-up. Pediatr Res 1997; 41:554-9.
28. Nilsen EM, Gjertsen HA, Jensen K, Brandtzaeg P, Lundin KE. Gluten activation of peripheral blood T cells induces a Th0-like cytokine pattern in both coeliac patients and controls. Clin Exp Immunol 1996; 103:295-303.
29. Hansson T, Dannaeus A, Klareskog L. Cytokine-producing cells in peripheral blood of children with coeliac disease secrete cytokines with a type 1 profile. Clin Exp Immunol 1999; 116:246-50.
30. Gu Y, Kuida K, Tsutsui H et al. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 1997; 275:206-9.
31. Fantuzzi G, Dinarello CA. Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1). J Clin Immunol 1999; 19:1-11.
32. Puren AJ, Fantuzzi G, Dinarello CA. Gene expression, synthesis, and secretion of interleukin 18 and interleukin lbeta are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc Natl Acad Sci USA 1999; 96:2256-61.
33. Siegmund B, Fantuzzi G, Rieder F et al. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am J Physiol Regul Integr Comp Physiol 2001; 281:R1264-73.
34. Tanaka H, Miyazaki N, Oashi K et al. IL-18 might reflect disease activity in mild and moderate asthma exacerbation. J Allergy Clin Immunol 2001; 107:331-6.
35. Wong CK, Ho CY, Ko FW, C et al. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol 2001; 125:177-83.
36. Yoshizawa Y, Nomaguchi H, Izaki S, Kitamura K. Serum cytokine levels in atopic dermatitis. Clin Exp Dermatol 2002; 27:225-9.
37. Verhaeghe B, Gevaert P, Holtappels G et al. Up-regulation of IL-18 in allergic rhinitis. Allergy 2002; 57:825-30.