Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a] quinoxaline-carboxylic acid hydrazide derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 19, Issue 6, 2004, Pages 489-495

  Guillon, Jean ^a   Reynolds, Robert C ^b   Leger, Jean Michel ^a   Guie, Marie Aude ^b   Massip, Stephane ^a   Dallemagne, Patrick ^c   Jarry, Christian ^a  

^a Laboratoire de Pharmacochimie   (France)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

Author keywords

Antimycobacterial agents; Mycobacterium tuberculosis; Pyrrolo 1,2 a quinoxaline carboxylic acid hydrazide derivatives; Tuberculosis

Indexed keywords

4 METHYLPYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLIC ACID HYDRAZIDE; 4 PHENYLPYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLIC ACID HYDRAZIDE; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; HYDRAZIDE DERIVATIVE; N' (2 HYDROXYBENZYLIDENE)PYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLIC ACID HYDRAZIDE; N' (2 HYDROXYBENZYLIDENE)PYRROLO[1,2 A]QUINOXALINE 4 CARBOXYLIC ACID HYDRAZIDE; N' (4 HYDROXYBENZYLIDENE)PYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLIC ACID HYDRAZIDE; N' (THIEN 2 YLMETHYLIDENE)PYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLIC ACID HYDRAZIDE; N' [1 (3,4 DICHLOROPHENYL)ETHYLIDENE]PYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLIC ACID HYDRAZIDE; N' BENZYLIDENEPYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLIC ACID HYDRAZIDE; N' BENZYLPYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLIC ACID HYDRAZIDE; PYRROLE DERIVATIVE; PYRROLO[1,2 A]QUINOXALINE 2 CARBOXYLIC ACID HYDRAZIDE; PYRROLO[1,2 A]QUINOXALINE 4 CARBOXYLIC ACID HYDRAZIDE; QUINOXALINE DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTITUBERCULAR AGENTS; CARBOXYLIC ACIDS; CELL PROLIFERATION; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; HYDRAZINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; QUINOXALINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 11244283299     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756360412331280464     Document Type: Article

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