Mannose binding lectin and C3 act as recognition molecules for infectious agents in the vagina

Clinical and Experimental Immunology

Volumn 139, Issue 1, 2005, Pages 120-126

  Pellis, V ^a   De Seta, F ^a   Crovella, S ^b   Bossi, F ^a   Bulla, R ^a   Guaschino, S ^a   Radillo, O ^a   Garred, P ^c   Tedesco, Francesco ^a,b  

^a IRCCS   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c Rigshospitalet   (Denmark)

Author keywords

C1q; C3; Candida albicans; Clue cells; MBL

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; MANNOSE BINDING LECTIN;

ADULT; ARTICLE; CANDIDA ALBICANS; CENTRIFUGATION; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT CLASSICAL PATHWAY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GARDNERELLA VAGINALIS; HUMAN; IMMUNOFLUORESCENCE TEST; MOLECULAR RECOGNITION; NONHUMAN; PH; PRIORITY JOURNAL; UTERINE CERVIX CYTOLOGY; VAGINA CANDIDIASIS; VAGINITIS;

ADOLESCENT; ADULT; BODY FLUIDS; CANDIDA ALBICANS; CANDIDIASIS, VULVOVAGINAL; COMPLEMENT C1Q; COMPLEMENT C3; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYDROGEN-ION CONCENTRATION; IRRIGATION; MANNOSE-BINDING LECTIN; VAGINA; VAGINOSIS, BACTERIAL;

EID: 11244271657     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02660.x     Document Type: Article

References (21)

1. Anon Non-reported sexually transmitted disease. Morb Mortal Wkly Rep 1979; 28:61-2.
2. Cauci S, Monte R, Driussi S, Lanzafame P, Quadrifoglio F. Impairment of the mucosal immune system: IgA and IgM cleavage detected in vaginal washings of a subgroup of patients with bacterial vaginosis. J Infect Dis 1998; 178:1698-706.
3. Amsel R, Totten PA, Spiegel CA, Chen KC, Eschenbach D, Holmes KK. Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med 1983; 74:14-22.
4. Mestecky J, Fultz PN. Mucosal immune system of the human genital tract. J Infect Dis 1999; 179 (Suppl. 3):S470-4.
5. Volanakis JE. Overview of the Complement System. In: Frank MM, ed. The Human Complement System in Human and Disease. New York: Marcel Dekker, 1998:9-32.
6. Babula O, Lazdane G, Kroica J, Ledger WJ, Witkin SS. Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women. Clin Infect Dis 2003; 37:733-7.
7. Larsen F, Madsen HO, Sim RB, Koch C, Garred P. Disease-associated Mutations in Human Mannose-binding Lectin Compromise Oligomerization and Activity of the Final Protein. J Biol Chem 2004; 279:21302-11.
8. Tedesco F, Roncelli L, Petersen BH, Agnello V, Sodetz JM. Two distinct abnormalities in patients with C8 alpha-gamma deficiency. Low level of C8 beta chain and presence of dysfunctional C8 alpha-gamma subunit. J Clin Invest 1990; 86:884-8.
9. Sambrook J, Fritsch EF, Maniatis T, eds. Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press, 1989
10. Hladnik U, Braida L, Boniotto M et al. Single-tube genotyping of MBL-2 polymorphisms using melting temperature analysis. Clin Exp Med 2002; 2:105-8.
11. Garred P, Madsen HO, Balslev U et al. Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin. Lancet 1997; 349:236-40.
12. Langeggen H, Pausa M, Johnson E, Casarsa C, Tedesco F. The endothelium is an extrahepatic site of synthesis of the seventh component of the complement system. Clin Exp Immunol 2000; 121:69-76.
13. Boniotto M, Braida L, Spano A et al. Variant mannose-binding lectin alleles are associated with celiac disease. Immunogenetics 2002; 54:596-8.
14. Saavedra M, Taylor B, Lukacs N, Fidel PL Jr. Local production of chemokines during experimental vaginal candidiasis. Infect Immun 1999; 67:5820-6.
15. Cauci S, Guaschino S, De Aloysio D et al. Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women. Mol Hum Reprod 2003; 9:53-8.
16. Kozel TR. Activation of the complement system by pathogenic fungi. Clin Microbiol Rev 1996; 9:34-46.
17. Edwards JE Jr, Gaither TA, O'Shea JJ et al. Expression of specific binding sites on Candida with functional and antigenic characteristics of human complement receptors. J Immunol 1986; 137:3577-83.
18. Heidenreich F, Dierich MP. Candida albicans and Candida stellatoidea, in contrast to other Candida species, bind iC3b and C3d but not C3b. Infect Immun 1985; 50:598-600.
19. Kozel TR, Brown RR, Pfrommer GS. Activation and binding of C3 by Candida albicans. Infect Immun 1987; 55:1890-4.
20. Jack DL, Klein NJ, Turner MW. Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosis. Immunol Rev 2001; 180:86-99.
21. Poulain D, Tronchin G, Dubremetz JF, Biguet J. Ultrastructure of the cell wall of Candida albicans blastospores: study of its constitutive layers by the use of a cytochemical technique revealing polysaccharides. Ann Microbiol (Paris) 1978; 129:141-53.