Identification of a novel transcriptional silencer in the protein-coding region of the human CYP2 C9 gene

Gene

Volumn 209, Issue 1-2, 1998, Pages 123-129

  Xiang, Shi Hua ^a   Parsons, Holly K ^a   Murray, Michael ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cis acting element; Cytochrome P450; Gene expression; Trans acting factor

Indexed keywords

CIS ACTING ELEMENT; CYTOCHROME P450; DNA; NUCLEAR PROTEIN; OLIGONUCLEOTIDE;

AFFINITY CHROMATOGRAPHY; ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HEP 2 CELL; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN DNA BINDING; SILENCER GENE; SOUTHERN BLOTTING; START CODON;

ARYL HYDROCARBON HYDROXYLASES; BASE SEQUENCE; BINDING SITES; CARCINOMA, HEPATOCELLULAR; CODON; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; DNA-BINDING PROTEINS; ENZYME REPRESSION; HUMANS; LIVER; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032536879     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(98)00017-1     Document Type: Article

References (34)

1. Baniahmad A., Steiner C., Kohne A.C., Renkawitz R. Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site. Cell. 61:1990;505-514.
2. Chen Y., Gill G.N. A heterodimeric nuclear protein complex binds two palindromic sequences in the proximal enhancer of the human erbB-2 gene. J. Biol. Chem. 271:1996;5183-5188.
3. Clark A.R., Docherty K. Negative regulation of transcription in eukaryotes. Biochem. J. 296:1993;524-541.
4. de Morais S.M.F., Schweikl H., Blaisdell J., Goldstein J.A. Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18. Biochem. Biophys. Res. Commun. 194:1993;194-201.
5. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in soluble extracts from isolated mammalian nuclei. Nucl.eic Acids Res. 11:1983;1475-1489.
6. Frenkel B., Mijnes J., Aronow M.A., Zambett G., Banerjee C., Stein J., Lian J.B., Stein G.S. Position and orientation-selective silencer in protein-coding sequences of the rat osteocalcin gene. Biochemistry. 32:1993;13636-13643.
7. George J., Liddle C., Murray M., Byth K., Farrell G.C. Pretranslational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis. Biochem. Pharmacol. 49:1995;873-881.
8. George J., Murray M., Byth K., Farrell G.C. Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease. Hepatology. 21:1995;120-128.
9. Goodbourn S. Negative regulation of transcriptional initiation in eukaryotes. Biochim. Biophys. Acta. 1032:1990;53-77.
10. Gorski K., Carneiro M., Schibler U. Tissue-specific in vitro transcription from the mouse albumin promoter. Cell. 47:1986;767-776.
11. Gray I.C., Nobile C., Muresu R., Ford S., Spurr N.K. A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. Genomics. 28:1995;328-332.
12. Guengerich, F.P., 1995. Human cytochrome P450 enzymes. In: Ortiz de Montellano, P.R. (ed.), Cytochrome P450: Structure, Mechanism and Biochemistry. Plenum Press, New York, pp. 473-535.
13. Hansen J.M., Siersbaek-Nielsen K., Skovsted L. Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man. Clin. Pharmacol. Ther. 12:1971;539-543.
14. Heimark L.D., Gibaldi M., Trager W.F., O'Reilly R.A., Goulart D.A. The mechanism of the warfarin-rifampicin drug interaction in humans. Clin. Pharmacol. Ther. 42:1987;388-394.
15. Hoeben R.C., Fallaux F.J., Cramer S.J., van den Wollenberg D.J.M., van Ormondt H., Brit E., van der Eb A.J. Expression of blood-clotting factor-VIII cDNA is repressed by a transcriptional silencer located in its coding region. Blood. 85:1995;2447-2454.
16. Hofman J.F.-X., Laroche T., Brand A.H., Gasser S.M. RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML. Cell. 57:1989;725-737.
17. Ibeanu G.C., Goldstein J.A. Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions. Biochemistry. 34:1995;8028-8036.
18. Keleher C.A., Goutte C., Johnson A.D. The yeast cell-type-specific repressor alpha 2 acts cooperatively with a non-cell-type-specific protein. Cell. 53:1988;927-936.
19. Levine M., Manley J.L. Transcriptional repression of eukaryotic promoters. Cell. 59:1989;405-408.
20. Li Y.-P., Chen W., Stashenko P. Characterization of a silencer element in the first exon of the human osteocalcin gene. Nucl. Acids Res. 23:1995;5064-5072.
21. Lowry O.H., Rosebrough N.T., Farr A.L., Randall A.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
22. MacDonald M.G., Robinson D.S., Sylwester D., Jaffe J.J. The effects of phenobarbital, chloral betaine, and glutethimide administration on warfarin plasma levels and hypoprothrombinemic responses in man. Clin. Pharmacol. Ther. 10:1969;80-84.
23. Nebert D.W., Gonzalez F.J. Cytochrome P450 gene expression and regulation. Trends Pharmacol. Sci. 6:1985;160-164.
24. Nebert D.W., Gonzalez F.J. P450 genes: structure, evolution, and regulation. Annu. Rev. Biochem. 56:1987;945-993.
25. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., Nebert D.W. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 6:1996;1-42.
26. Pierce J.W., Gifford A.M., Baltimore D. Silencing of the expression of the immunoglobulin kappa gene in non-B cells. Mol. Cell. Biol. 11:1991;1431-1437.
27. Ren L., Chen H., Sternberg E.A. Tethered bandshift assay and affinity purification of a new DNA-binding protein. Biotechniques. 16:1994;852-855.
28. Renkawitz R. Transcriptional repression in eukaryotes. Trends Genet. 6:1990;192-197.
29. Shephard E.A., Phillips I.R., Santisteban I., Palmer C.N.A., Povery S. Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family. Ann. Hum. Genet. 53:1989;23-31.
30. Shimada T., Yamazaki H., Mimura M., Inui Y., Guengerich F.P. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther. 270:1994;414-423.
31. Shimokawa T., Fujimoto H. Identification of a transcriptional silencer in the protein-coding region of the mouse major inducible Hsp70 gene. Biochem. Biophys. Res. Commun. 221:1996;843-846.
32. Targa F.R., de Moura Gallo C.V., Huesca M., Scherrer K., Marcaud L. Silencer and enhancer elements located at the 3′-side of the chicken and duck alpha-globin-encoding gene domains. Gene. 129:1993;229-237.
33. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. USA. 76:1979;4350-4354.
34. Watkins P.B., Wrighton S.A., Maurel P., Scheutz E.G., Mendez-Picon G., Parker G.A., Guzelian P.S. Identification of an inducible form of cytochrome P-450 in human liver. Proc. Natl Acad. Sci. USA. 82:1985;6310-6314.