Functional and morphological changes of lumbar nerve roots induced by mechanical compression or the nucleus pulposus in contact with the root: Analysis of fiber size-dependent vulnerability in rabbits

Journal of Orthopaedic Science

Volumn 9, Issue 6, 2004, Pages 598-604

  Sakamoto, Yoshihiro ^a   Nakamura, Takafumi ^a   Takagi, Katsumasa ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Compound action potential; Mechanical compression; Nerve fiber diameter; Nucleus pulposus; Rabbit

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOLOGY; MALE; MORPHOLOGY; MYELINATED NERVE; NERVE CONDUCTION; NERVE FIBER; NERVE ROOT COMPRESSION; NERVE ROOT INJURY; NONHUMAN; NUCLEUS PULPOSUS; RABBIT; SPINAL ROOT; STATISTICAL SIGNIFICANCE;

EID: 11244258804     PISSN: 09492658     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00776-004-0837-9     Document Type: Article

References (28)

1. Cornefjord M, Olmarker K, Farley DB, et al. Neuropeptide changes in compressed spinal nerve roots. Spine 1995;20:670-3.
2. Garfin SR, Cohen MS, Massie JB, et al. Nerve-roots of the cauda equina. The effect of hypertension and acute graded compression on function. J Bone Joint Surg [Am] 1990;72:1185-92.
3. Gasser HS, Erlanger J. Electrical signs of nervous activity. Philadelphia: University of Pennsylvania Press: 1937. p. 167-9.
4. Hasue M. Pain and the nerve root. An interdisciplinary approach. Spine 1993;18:2053-8.
5. Iwamoto H, Matsuda H, Noriage A, et al. Lumbar spinal canal stenosis examined electrophysiologically in a rat model of chronic cauda equina compression. Spine 1997;22:2636-40.
6. 2. Spine 1996;21:271-7.
7. Kawakami M, Tamaki T, Weinstein JN, et al. Pathomachanism of pain-related behavior produced by allografts of intervertebral disc in the rat. Spine 1996;21:2101-7.
8. Kawakami M, Weinstein JN, Chatani K, et al. Experimental lumbar radiculopathy. Behavioral and histologic changes in a model of radicular pain after spinal nerve root irritation with chromic gut ligatures in the rat. Spine 1994;19:1795-802.
9. Kayama S, Konno S, Olmarker K, et al. Incision of the anulus fibrosus induces nerve root morphologic, vascular, and functional changes. An experimental study. Spine 1996;21:2539-43.
10. 1) on nerve-conduction velocity in the dog cauda equina subjected to acute experimental compression. J Spinal Disord 1996;9:103-6.
11. Matsui H, Kanamori M, Kawaguchi Y, et al. Clinical and electrophysiologic characteristics of compressed lumbar nerve roots. Spine 1997;22:2100-5.
12. Nygaad ØP, Mellgren SI. The function of sensory nerve fibers in lumbar radiculopathy. Use of quantitative sensory testing in the exploration of different populations of nerve fibers and dermatomes. Spine 1996;23:348-53.
13. Olmarker K, Byröd G, Cornefjord M, et al. Effects of methylprednisolone on nucleus pulposus-induced nerve root injury. Spine 1994;19:1803-8.
14. Olmarker K, Rydevik B, Nordborg C. Autologous nucleus pulposus induces neurophysiologic and histologic changes in porcine cauda equina nerve roots. Spine 1993;18:1425-32.
15. Olmarker K. Spinal nerve root compression. Nutrition and function of the porcine cauda equina compressed in vivo. Acta Orthop Scand (Suppl) 1991;242:1-27.
16. Olmarker K, Rydevik B, Hansson T, et al. Compression-induced changes of the nutritional supply to the porcine cauda equina. J Spinal Disord 1990;3:25-9.
17. Olmarker K, Myers RR, Pathogenesis of sciatic pain: role of herniated nucleus pulposus and deformation of spinal nerve root and dorsal root ganglion. Pain 1998;78:99-105.
18. Olmarker K, Larsson K. Tumor necrosis factor α and nucleus-pulposus-induced nerve root injury. Spine 1998;23:2538-44.
19. Olmarker K, Nordborg C, Larsson K, et al. Ultrastructural changes in spinal nerve roots induced by autologous nucleus pulposus. Spine 1996;21:411-14.
20. Olmarker K, Blomquist J, Strömberg J, et al. Inflammatogenic properties of nucleus pulposus. Spine 1995;20:665-9.
21. Otani K, Arai, I, Mao GP, et al. Experimental disc herniation: evaluation of the natural course. Spine 1997;22:2894-9.
22. Rothoerl RD, Woertgen C, Holzschuh M, et al. Is there a clinical correlate to the histologic evidence of inflammation in herniated lumbar disc tissue? Spine 1998;23:1197-201.
23. Saal JS, The role of inflammation in lumbar pain. Spine 1995;20:1821-7.
24. Sato K, Konno S, Yabuki S, et al. A model for acute, chronic, and delayed graded compression of the dog cauda equina. Neurophysiologic and histologic changes induced by acute, graded compression. Spine 1995;20:2386-91.
25. Satoh K, Konno S, Nishiyama K, et al. Presence and distribution of antigen-antibody complexes in the herniated nucleus pulposus. Spine 1999;24:1980-4.
26. Toh E, Mochida J. Histologic analysis of the lumbosacral nerve roots after compression in young and aged rabbits. Spine 1997;22:721-6.
27. Yabuki S, Kikuchi S, Olmarker K, et al. Acute effects of nucleus pulposus on blood flow and endneurial fluid pressure in rat dorsal root ganglia. Spine 1998;23:2517-23.
28. Yoshizawa H, Kobayashi S, Morita T. Chronic nerve root compression. Pathophysiologic mechanism of nerve root dysfunction. Spine 1995;20:397-407.