An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles

Tetrahedron Letters

Volumn 44, Issue 14, 2003, Pages 2903-2905

  Engler, Thomas A ^a   Furness, Kelly ^a   Malhotra, Sushant ^a   Diefenbacher, Clive ^a   Clayton, Joshua R ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE DERIVATIVE; ALDEHYDE DERIVATIVE; CYANOHYDRIN; DIETHYLCYANOPHOSPHONATE; LITHIUM; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CATALYSIS; CHEMICAL REACTION; PHOSPHORYLATION; THIN LAYER CHROMATOGRAPHY;

EID: 0037474662     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)00427-1     Document Type: Article

References (21)

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19. 3a.
20. 2 solutions or generating it in situ in order to limit the number of required operations to a minimum, thus adding to the overall simplicity of the process. A crude determination of the amount of reductant required is accomplished simply by visually following the color of the reactions.
21. 2: C, 77.62; H, 5.92; N, 16.46. Found: C, 78.01; H, 5.97; N, 16.49.